GenAge entry for SP1 (Homo sapiens)

Gene name (HAGRID: 170)

HGNC symbol
SP1 
Aliases
 
Common name
Sp1 transcription factor 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

An important transcription factor, SP1 is involved in the regulation of many genes, including ageing-related genes such as WRN [819] or cellular senescence-related genes like CDKN2A [3616]. Some results have linked SP1 disruption to Huntington's disease [534]. SP1 was shown to be dowregulated in cellular senescence, and under DNA damage signaling regulation [3667]. SP1 is involved in so many processes that it is possible for SP1 to play some role in human ageing.

Cytogenetic information

Cytogenetic band
12q13.1
Location
53,380,195 bp to 53,416,442 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001503; ossification
GO:0001829; trophectodermal cell differentiation
GO:0001889; liver development
GO:0001892; embryonic placenta development
GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-dependent
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0007179; transforming growth factor beta receptor signaling pathway
GO:0010467; gene expression
GO:0019048; modulation by virus of host morphology or physiology
GO:0030219; megakaryocyte differentiation
And 12 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0032993; protein-DNA complex
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979; RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001103; RNA polymerase II repressing transcription factor binding
GO:0003677; DNA binding
GO:0003690; double-stranded DNA binding
GO:0003700; sequence-specific DNA binding transcription factor activity
GO:0005515; protein binding
GO:0008022; protein C-terminus binding
GO:0008134; transcription factor binding
GO:0035035; histone acetyltransferase binding
And 9 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, WRN, E2F1, BRCA1, CEBPB, PML, HTT, RB1, RELA, HDAC1, JUN, HSPA8, HDAC2
STRING interaction network
Protein-Protein network diagram for SP1

Retrieve sequences for SP1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
sp1
Mus musculus
Sp1
Rattus norvegicus
Sp1

In other databases

CellAge
  • This gene is present as SP1

Selected references

External links

EPD
ORF Accession
NM_138473
CDS Accession
NP_612482
OMIM
189906
HPRD
01796
Ensembl
SP1
UniProt/Swiss-Prot
SP1_HUMAN
GeneCards
SP1
Entrez Gene
6667
UniGene
649191
GenAtlas
SP1
Internet
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