GenAge entry for GRN (Homo sapiens)

Gene name (HAGRID: 300)

HGNC symbol
GRN 
Aliases
PCDGF; PGRN; CLN11 
Common name
granulin 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

GRN is an autocrine growth factor. Knockout mice exhibit decreased survival, with less than 50% of animals living more than 2 years, and signs of cellular ageing, though not necessarily progeroid features [3263]. Results from knockout mice also suggest a role for GRN in maintaining neuronal function during ageing [3442]. In humans, GRN mutations have been associated with dementia [3445], but whether GRN is involved in broader aspects of ageing is unknown.

Cytogenetic information

Cytogenetic band
17q21.32
Location
44,345,086 bp to 44,353,106 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0007165; signal transduction
Cellular component: GO:0005615; extracellular space
GO:0043231; intracellular membrane-bounded organelle
GO:0070062; extracellular exosome
Function: GO:0005125; cytokine activity
GO:0005515; protein binding
GO:0008083; growth factor activity
GO:0044822; poly(A) RNA binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
EGFR, CACNA1A, TOP3B, SIRT3
STRING interaction network
Protein-Protein network diagram for GRN

Retrieve sequences for GRN

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
grna
Mus musculus
Grn
Rattus norvegicus
Grn

Selected references

External links

EPD
HS_GRN
ORF Accession
NM_002087
CDS Accession
NP_002078
OMIM
138945
HPRD
00733
Ensembl
GRN
UniProt/Swiss-Prot
GRN_HUMAN
GeneCards
GRN
Entrez Gene
2896
UniGene
514220
GenAtlas
GRN
Internet
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