Release date: September 15, 2012
Number of genes in model organisms: 1,712
Number of human genes: 288
Build 16 is a major update, in terms of content, database structure and interface. The set of human ageing genes has increased only slightly, while previously existing data has been further curated, resulting in the addition of several hundred bibliographic references and changes in the main reason for selection, for some genes. Observations concerning a few genes were also updated to reflect new findings. A new criterion for selection (“Entry selected based on evidence directly linking the gene product to ageing in humans”) has been added in this build, in order to properly reflect the current level of understanding in several gene cases.
The model organisms’ sets have been broadly extended, and build 16 hosts a total of 1,712 genes associated with longevity. In addition to the increase in the number of entries, we have altered the database schema allowing us to host for each longevity-associated gene multiple observations from the same or different studies. Overall, GenAge provides 2,121 lifespan observations of which only a small number (accounting for 4% of the genes) represent conflicting results. We have also updated the structure and content of the database to include more extensive quantitative information. More than 1,250 observations, accounting for 1,057 genes for model organisms have been annotated with data on the effect (relative change) that a certain genetic intervention has on the mean and/or maximal lifespan. Additionally, we have recorded the type of intervention and categorized longevity-associated genes either as pro-longevity or anti-longevity.
A few gene symbols were also updated according to the latest nomenclatures.
Please remember these notes refer to the latest stable build of GenAge. The current GenAge stats may differ slightly from the above due to changes after the build's release.
More information concerning the design and curation of GenAge is available elsewhere. Use of GenAge is free but subject to the conditions of the Human Ageing Genomic Resources.
Comments, suggestions, ideas, and bug reports are welcome. Please contact us.