GenAge entry for HDAC1 (Homo sapiens)

Gene name (HAGRID: 151)

HGNC symbol
HDAC1 
Aliases
HD1; GON-10; RPD3L1 
Common name
histone deacetylase 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

HDAC1 performs the deacetylation of histones and is an important player in may processes such as development, transcriptional regulation, and cell cycle progression [736]. Homologues of HDAC1 have been linked to longevity in yeast [203] and to ageing and caloric restriction in fruit flies [202]. Whether HDAC1 is involved in human ageing, however, is unknown.

Cytogenetic information

Cytogenetic band
1p34
Location
32,292,107 bp to 32,333,623 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000278; mitotic cell cycle
GO:0006338; chromatin remodeling
GO:0006351; transcription, DNA-templated
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0006476; protein deacetylation
GO:0007179; transforming growth factor beta receptor signaling pathway
GO:0007219; Notch signaling pathway
GO:0007596; blood coagulation
GO:0008284; positive regulation of cell proliferation
GO:0009913; epidermal cell differentiation
And 22 more GO terms
Cellular component: GO:0000118; histone deacetylase complex
GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0016580; Sin3 complex
GO:0016581; NuRD complex
Function: GO:0001047; core promoter binding
GO:0001103; RNA polymerase II repressing transcription factor binding
GO:0001106; RNA polymerase II transcription corepressor activity
GO:0003700; sequence-specific DNA binding transcription factor activity
GO:0004407; histone deacetylase activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019899; enzyme binding
GO:0032041; NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558; protein deacetylase activity
GO:0033613; activating transcription factor binding
And 5 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, HDAC3, NCOR1, BRCA1, TOP2A, TOP2B, NFKB1, PML, AR, PCNA, RB1, RELA, SP1, SIN3A, HDAC2, MXD1, MDM2, SUMO1, HIC1
STRING interaction network
Protein-Protein network diagram for HDAC1

Retrieve sequences for HDAC1

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Drosophila melanogaster
Rpd3
Danio rerio
hdac1
Mus musculus
Hdac1
Rattus norvegicus
Hdac1
Saccharomyces cerevisiae
RPD3

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as RPD3
  • A homolog of this gene for Drosophila melanogaster is present as Rpd3
GenDR gene manipulations
  • A homolog of this gene for Drosophila melanogaster is present as Rpd3
  • A homolog of this gene for Saccharomyces cerevisiae is present as RPD3
CellAge
  • This gene is present as HDAC1

Selected references

External links

EPD
HS_HDAC1
ORF Accession
NM_004964
CDS Accession
NP_004955
OMIM
601241
HPRD
03143
Ensembl
HDAC1
UniProt/Swiss-Prot
HDAC1_HUMAN
GeneCards
HDAC1
Entrez Gene
3065
UniGene
88556
GenAtlas
HDAC1
Internet
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