GenAge entry for HELLS (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 101)

HGNC symbol
HELLS 
Aliases
PASG; SMARCA6; LSH; Nbla10143 
Common name
helicase, lymphoid-specific 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

HELLS is a transcriptional regulator acting on chromatin and maybe affecting cellular proliferation. It has been linked to leukaemia [1047]. About 60% of HELLS-null mice die shortly after birth. Survivors do not commonly live more than a month but exhibit growth retardation and signs of premature ageing [1045]. Whether HELLS impacts on human ageing is unknown.

Cytogenetic information

Cytogenetic band
10q24.2
Location
94,545,767 bp to 94,602,099 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001655; urogenital system development
GO:0006346; methylation-dependent chromatin silencing
GO:0006351; transcription, DNA-templated
GO:0007067; mitosis
GO:0007275; multicellular organismal development
GO:0010216; maintenance of DNA methylation
GO:0031508; centromeric heterochromatin assembly
GO:0043066; negative regulation of apoptotic process
GO:0046651; lymphocyte proliferation
GO:0051301; cell division
Cellular component: GO:0000775; chromosome, centromeric region
GO:0005634; nucleus
GO:0005721; centromeric heterochromatin
Function: GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0004386; helicase activity
GO:0005515; protein binding
GO:0005524; ATP binding
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for HELLS

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
hells
Mus musculus
Hells
Rattus norvegicus
LOC100911660
Saccharomyces cerevisiae
IRC5

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Hells

Selected references

External links

EPD
ORF Accession
NM_018063
CDS Accession
NP_060533
OMIM
603946
HPRD
07232
Ensembl
HELLS
UniProt/Swiss-Prot
HELLS_HUMAN
GeneCards
HELLS
Entrez Gene
3070
UniGene
655830
GenAtlas
HELLS
Internet
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