GenAge entry for HSPA9 (Homo sapiens)

Gene name (HAGRID: 152)

HGNC symbol
HSPA9 
Aliases
GRP75; PBP74; mot-2; mthsp75; HSPA9B 
Common name
heat shock 70kDa protein 9 (mortalin) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

HSPA9 appears to be involved in apoptosis and maybe cellular proliferation. It could also be a molecular chaperone. Roundworms with extra copies of Hsp70F, a HSPA9 homologue, live about 40% longer than controls [904]. A role for HSPA9 in human ageing has not been established.

Cytogenetic information

Cytogenetic band
5q31.1
Location
138,554,882 bp to 138,575,629 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006457; protein folding
GO:0006611; protein export from nucleus
GO:0030218; erythrocyte differentiation
GO:0043066; negative regulation of apoptotic process
GO:0045647; negative regulation of erythrocyte differentiation
GO:1902037; negative regulation of hematopoietic stem cell differentiation
Cellular component: GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005925; focal adhesion
GO:0031012; extracellular matrix
GO:0042645; mitochondrial nucleoid
GO:0043209; myelin sheath
GO:0070062; extracellular exosome
Function: GO:0005515; protein binding
GO:0005524; ATP binding
GO:0031625; ubiquitin protein ligase binding
GO:0044822; poly(A) RNA binding
GO:0051082; unfolded protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, TP53, AKT1, EGFR, HSP90AA1, GRB2, SOD1, APP, SIRT1, HSPD1, SP1, EEF1A1, HSPA8, H2AFX, CDKN2A, SIRT7, SIRT3, TP73, CDKN1A, SPRTN
STRING interaction network
Protein-Protein network diagram for HSPA9

Retrieve sequences for HSPA9

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
hsp-6
Danio rerio
hspa9
Drosophila melanogaster
Hsc70-5
Mus musculus
Hspa9
Rattus norvegicus
Hspa9
Saccharomyces cerevisiae
ECM10
Schizosaccharomyces pombe
ssp1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as hsp-6

Selected references

External links

EPD
HS_HSPA9B_1
ORF Accession
NM_004134
CDS Accession
NP_004125
OMIM
600548
HPRD
02770
Ensembl
HSPA9
UniProt/Swiss-Prot
GRP75_HUMAN
GeneCards
HSPA9
Entrez Gene
3313
UniGene
184233
GenAtlas
HSPA9
Internet
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