Papers and Relevant Publications

The Human Ageing Genomic Resources and its associated resources have been featured in several publications, including official descriptions and analyses by HAGR's authors, and numerous publications by other researchers.

Official descriptions of HAGR

The official, up-to-date paper describing the Human Ageing Genomic Resources is:

Tacutu, R., et al. (2013) "Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing." Nucleic Acids Research 41(D1):D1027-D1033.

We ask that authors using our resources cite the above description of HAGR as it not only details numerous recent updates and enhancements but also as a way to credit new contributors not included in our previous description of HAGR. Previous, outdated descriptions of HAGR and its resources were:

de Magalhaes, J. P., et al. (2005) "HAGR: the Human Ageing Genomic Resources." Nucleic Acids Res 33(Database Issue):D537-D543.

de Magalhaes, J. P., et al. (2009) "The Human Ageing Genomic Resources: online databases and tools for biogerontologists." Aging Cell 8(1):65-72.

de Magalhaes, J. P., and Costa, J. (2009) "A database of vertebrate longevity records and their relation to other life-history traits." Journal of Evolutionary Biology 22(8):1770-1774.

Authors employing only particular HAGR databases or datasets are asked to cite specific papers, as detailed elsewhere. Please also refer to the various analyses we have already performed.

Broad analyses of HAGR datasets by its authors

We have conducted a number of broad, large-scale analyses using HAGR databases. Firstly, we obtained a visualization and interpretation of the genomic and proteomic network of ageing using GenAge:

de Magalhaes, J. P., and Toussaint, O. (2004) "GenAge: a genomic and proteomic network map of human ageing." FEBS Lett 571(1-3):243-247.

An analysis of molecular evolution rates of GenAge was done employing human-chimpanzee gene pairs:

de Magalhaes, J. P., and Church, G. M. (2007) "Analyses of human-chimpanzee orthologous gene pairs to explore evolutionary hypotheses of aging." Mech Ageing Dev 128(5-6):355-364.

We performed an analysis of the gene network of dietary restriction using GenDR:

Wuttke, D., et al. (2012) "Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes." PLoS Genetics 8(8):e1002834.

Our molecular signatures of ageing were derived from a meta-analysis of ageing microarray data:

de Magalhaes, J. P., et al. (2009) "Meta-analysis of age-related gene expression profiles identifies common signatures of aging." Bioinformatics 25(7):875-881.

Likewise, the molecular signatures of DR were derived from a meta-analysis:

Plank, M., et al. (2012) "A meta-analysis of caloric restriction gene expression profiles to infer common signatures and regulatory mechanisms." Molecular BioSystems 8(4):1339-1349.

Finally, we took advantage of the AnAge dataset to evaluate the relationship between metabolic rates, growth rates, developmental timing, and longevity:

de Magalhaes, J. P., et al. (2007) "An analysis of the relationship between metabolism, developmental schedules, and longevity using phylogenetic independent contrasts." J Gerontol A Biol Sci Med Sci 62(2):149-160.

Highlights in scientific journals

The Human Ageing Genomic Resources have been highlighted in:

Other academic publications using and/or citing HAGR

Chung, H.Y., et al. (2004) "Molecular inflammation hypothesis of aging." Kor J Gerontol 14(1):12-19.

de Magalhaes, J.P. (2005) "Open-minded scepticism: inferring the causal mechanisms of human ageing from genetic perturbations." Ageing Res Rev 4(1):1-22.

Morris, B.J. (2005) "A forkhead in the road to longevity: the molecular basis of lifespan becomes clearer." J Hypertens 23(7):1285-1309.

Raghothama, C., et al. (2005) "Bioinformatics and proteomics approaches for aging research." Biogerontology 6(4):227-232.

Karasik, D., et al. (2005) "Disentangling the genetic determinants of human aging: biological age as an alternative to the use of survival measures." J Gerontol A Biol Sci Med Sci 60(5):574-587.

de Magalhaes, J.P. (2005) "Human disease-associated mitochondrial mutations fixed in nonhuman primates." J Mol Evol 61(4):491-497.

Galvin, J.E., and Ginsberg, S. D. (2005) "Expression profiling in the aging brain: a perspective." Ageing Res Rev 4(4):529-547.

Fried, L.P., et al. (2005) "From bedside to bench: research agenda for frailty." Sci Aging Knowledge Environ 2005(31):pe24.

Blalock, E.M., et al. (2005) "Harnessing the power of gene microarrays for the study of brain aging and Alzheimer's disease: statistical reliability and functional correlation." Ageing Res Rev 4(4):481-512.

Ruggiero, C., and Ferrucci, L. (2006) "The endeavor of high maintenance homeostasis: resting metabolic rate and the legacy of longevity." J Gerontol A Biol Sci Med Sci 61(5):466-471.

Rottenberg, H. (2006) "Longevity and the evolution of the mitochondrial DNA-coded proteins in mammals." Mech Ageing Dev 127(9):748-760.

Lehmann, G. et al. (2006) "Mitochondrial genome anatomy and species-specific lifespan." Rejuvenation Res 9(2):223-226.

Khaidakov, M., et al. (2006) "Direct repeats in mitochondrial DNA and mammalian lifespan." Mech Ageing Dev 127(10):808-812.

Kriete, A., et al. (2006) "Systems approaches to the networks of aging." Ageing Res Rev 5(4):434-448.

Swynghedauw, B., et al. (2006) "Biology of cardiac and vascular senescence." [Article in French] Bull Acad Natl Med 190(4-5):783-792.

Murakami, S. (2006) "Stress resistance in long-lived mouse models." Exp Gerontol 41(10):1014-1019.

Harper, J.M., et al. (2007) "Skin-derived fibroblasts from long-lived species are resistant to some, but not all, lethal stresses and to the mitochondrial inhibitor rotenone." Aging Cell 6(1):1-13.

Seluanov, A., et al. (2007) "Telomerase activity coevolves with body mass not lifespan." Aging Cell 6(1):45–52.

Rottenberg, H. (2007) "Coevolution of exceptional longevity, exceptionally high metabolic rates, and mitochondrial DNA-coded proteins in mammals." Exp Gerontol 42(4):364-373.

Rottenberg, H. (2007) "Exceptional longevity in songbirds is associated with high rates of evolution of cytochrome b, suggesting selection for reduced generation of free radicals." J Exp Biol 210(12):2170-2180.

Martin, G.M., et al. (2007) "Genetic determinants of human health span and life span: progress and new opportunities." PLoS Genet 3(7):e125.

Kahn, A.J. (2007) "Epigenetic and mitochondrial mechanisms in aging and longevity: a report of a meeting of the Longevity Consortium, Napa, California, October 25-27, 2006." J Gerontol A Biol Sci Med Sci 62(6):577-582.

Lambert, A.J., et al. (2007) "Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms." Aging Cell 6(5):607-618.

Lunetta, K.L., et al. (2007) "Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study." BMC Med Genet 6(Suppl 1):S13.

Huhne, R., et al. (2007) "A comparative view at comprehensive information resources on three-dimensional structures of biological macro-molecules." Brief Funct Genomic Proteomic 6(3):220-239.

Xue, H., et al. (2007) "A modular network model of aging." Mol Syst Biol 3:147.

Pletcher, S.D., et al. (2007) "Chemical complexity and the genetics of aging." Annu Rev Ecol Evol Syst 38:299-326.

Moosmann, B., and Behl, C. (2008) "Mitochondrially encoded cysteine predicts animal lifespan." Aging Cell 7(1):32-46.

Nabholz, B., et al. (2008) "Determination of mitochondrial genetic diversity in mammals." Genetics 178(1):351-361.

Nabholz, B., et al. (2008) "Strong variations of mitochondrial mutation rate across mammals--the longevity hypothesis." Mol Biol Evol 25(1):120-130.

Georgopoulo, P. G. (2008) "A multiscale approach for assessing the interactions of environmental and biological systems in a holistic health risk assessment framework." Water Air Soil Pollut Focus 8(1):3-21.

Sebastiani, P., et al. (2008) "A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples." BMC Med Genet 9:6.

Chen, D.P., et al. (2008) "Novel integration of hospital electronic medical records and gene expression measurements to identify genetic markers of maturation." Pac Symp Biocomput 243-254.

Buffenstein, R. (2008) "Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species." J Comp Physiol [B] 178(4):439-445.

Welch, J.J., et al. (2008) "Correlates of substitution rate variation in mammalian protein-coding sequences." BMC Evol Biol 8:53.

Kleine, L.L., et al. (2008) "Role of bacterial peptidase F inferred by statistical analysis and further experimental validation." HFSP J 2(1):29-41.

Jorge, M.L.S.P. (2008) "Effects of forest fragmentation on two sister genera of Amazonian rodents (Myoprocta acouchy and Dasyprocta leporina)." Biol Conserv 141(3):617-623.

da Fonseca, R.R., et al. (2008) "The adaptive evolution of the mammalian mitochondrial genome." BMC Genomics 9:119.

Asher, R.J., and Lehmann, T. (2008) "Dental eruption in afrotherian mammals." BMC Genomics 6:14.

Lehmann, G., et al. (2008) "Do mitochondrial DNA and metabolic rate complement each other in determination of the mammalian maximum longevity?" Rejuvenation Res 11(2):409-417.

Gielchinsky, Y., et al. (2008) "Gene expression in women conceiving spontaneously over the age of 45 years." Fertil Steril 89(6):1641-1650.

Pang, C.Y., et al. (2008) "MtDNA mutations, functional decline and turnover of mitochondria in aging." Front Biosci 13(6):3661-3675.

Han, L., et al. (2008) "CpG island density and its correlations with genomic features in mammalian genomes." Genome Biol 9(5):R79.

Hardman, M.J., and Ashcroft, G. S. (2008) "Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly." Genome Biol 9(5):R80.

de Magalhaes, J.P., and Faragher, R. G. (2008) "Cell divisions and mammalian aging: integrative biology insights from genes that regulate longevity." Bioessays 30(6):567-578.

Furness, L.J., and Speakman, J. R. (2008) "Energetics and longevity in birds." AGE 30(2-3):75-87.

Buffenstein, R., et al. (2008) "The oxidative stress theory of aging: embattled or invincible? Insights from non-traditional model organisms." AGE 30(2-3):99-109.

Seluanov, A., et al. (2008) "Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan." Aging Cell 7(6):813-823.

Min, X.J., and Hickey, D. A. (2008) "An evolutionary footprint of age-related natural selection in mitochondrial DNA." J Mol Evol 67(4):412-417.

Lehmann, G., et al. (2008) "Mitochondrial determinants of mammalian longevity." Probl Aging Longevity (Kiev) 17:211-229.

Kitazoe, Y., et al. (2008) "Adaptive threonine increase in transmembrane regions of mitochondrial proteins in higher primates." PLoS ONE 3(10):e3343.

Managbanag, J. R., et al. (2008) "Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity." PLoS ONE 3(11):e3802.

Mumby, H., and Vinicius, L. (2008) "Primate growth in the slow lane: a study of inter-species variation in the growth constant A." Evol Biol 35(4):287-295.

Robb, E.L., et al. (2009) "Mitochondria, cellular stress resistance, somatic cell depletion and lifespan." Curr Aging Sci 2(1):12-27.

Gorbunova, V., and Seluanov, A. (2009) "Coevolution of telomerase activity and body mass in mammals: from mice to beavers." Mech Ageing Dev 130(1-2):3-9.

Budovsky, A., et al. (2009) "Common gene signature of cancer and longevity." Mech Ageing Dev 130(1-2):33-39.

Rattan, S.I., and Singh, R. (2009) "Progress & prospects: gene therapy in aging." Gene Ther 16(1):3-9.

Austad, S.N. (2009) "Comparative biology of aging." J Gerontol A Biol Sci Med Sci 64(2):199-201.

Buffenstein, R., and Pinto, M. (2009) "Endocrine function in naturally long-living small mammals." Mol Cell Endocrinol 299(1):101-111.

Wolfson, M., et al. (2009) "The signaling hubs at the crossroad of longevity and age-related disease networks." Int J Biochem Cell Biol 41(3):516-520.

Altar, C.A. et al. (2009) "Target identification for CNS diseases by transcriptional profiling." Neuropsychopharmacology 34(1):18-54.

Bonatto, C.C. et al. (2009) "Shape and size of red blood cells from the Pygoscelid penguins of Antarctica using atomic force microscopy." Polar Biol 32(2):287-293.

Nabholz, B. et al. (2009) "The erratic mitochondrial clock: variations of mutation rate, not population size, affect mtDNA diversity across birds and mammals." BMC Evol Biol 9:54.

Galtier, N. et al. (2009) "Inverse relationship between longevity and evolutionary rate of mitochondrial proteins in mammals and birds." Mitochondrion 9(1):51-57.

Bostock, C.V. et al. (2009) "Genetic determinants of ageing processes and diseases in later life." Maturitas 62(3):225-229.

Lynch, H.J., and Fagan, W.F. (2009) "Survivorship curves and their impact on the estimation of maximum population growth rates." Ecology 90(4):1116-1124.

Asher, R.J., and Olbricht, G. (2009) "Dental ontogeny in Macroscelides proboscideus (Afrotheria) and Erinaceus europaeus (Lipotyphla)." J Mamm Evol 16(2):99-115.

Estep, P.W. et al. (2009) "Short-term calorie restriction in male mice feminizes gene expression and alters key regulators of conserved aging regulatory pathways." PLoS One 4(4):e5242.

Somel, M. et al. (2009) "Transcriptional neoteny in the human brain." Proc Natl Acad Sci U S A 106(14):5743-5748.

Demetrius, L. et al. (2009) "Evolutionary entropy: a predictor of body size, metabolic rate and maximal life span." Bull Math Biol 71(4):800-818.

Emamian, E.S. et al. (2009) "Peripheral blood gene expression profiling in Sjögren's syndrome." Genes Immun 10(4):285-296.

Rosenstiel, P. et al. (2009) "Evolution and function of innate immune receptors - insights from marine invertebrates." J Innate Immun 1(4):291-300.

Karol, M.H. (2009) "How environmental agents influence the aging process." Biomolecules & Therapeutics 17(2):113-124.

Forero-Medina, G. et al. (2009) "Body size and extinction risk in Brazilian carnivores." Biota Neotrop 9(2).

Halaschek-Wiener, J. et al. (2009) "Genetic variation in healthy oldest-old." PLoS One 4(8):e6641.

Zhang, T. et al. (2009) "The effect of osteoprotegerin gene modification on wear debris-induced osteolysis in a murine model of knee prosthesis failure." Biomaterials 30(30):6102-6108.

Zetterberg, H. et al. (2009) "The szilard hypothesis on the nature of aging revisited." Genetics 182(1):3-9.

Gillis, J., and Pavlidis, P. (2009) "A methodology for the analysis of differential coexpression across the human lifespan." BMC Bioinformatics 10:306.

Wang, J. et al. (2009) "Disease-aging network reveals significant roles of aging genes in connecting genetic diseases." PLoS Comput Biol 5(9):e1000521.

Simko, G.I. et al. (2009) "Network strategies to understand the aging process and help age-related drug design." Genome Med 1(9):90.

Lescai, F. et al. (2009) "Human longevity and 11p15.5: a study in 1321 centenarians." Eur J Hum Genet 17(11):1515-1519.

Faragher, R.G. et al. (2009) "Can we intervene in human ageing?" Expert Rev Mol Med 11:e27.

Sedivy, J.M. (2009) "How to learn new and interesting things from model systems based on "exotic" biological species." Proc Natl Acad Sci U S A 106(46):19207-19208.

Seluanov, A. et al. (2009) "Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat." Proc Natl Acad Sci U S A 106(46):19352-19357.

Argmann, C. et al. (2009) "Ppargamma2 is a key driver of longevity in the mouse." PLoS Genet 5(12):e1000752.

Kohler, M., and Moya-Sola, S. (2009) "Physiological and life history strategies of a fossil large mammal in a resource-limited environment." Proc Natl Acad Sci U S A 106(48):20354-20358.

Munshi-South, J., and Wilkinson, G.S. (2010) "Bats and birds: Exceptional longevity despite high metabolic rates." Ageing Res Rev 9(1):12-19.

Philipp, E.E., and Abele D. (2010) "Masters of longevity: lessons from long-lived bivalves--a mini-review." Gerontology 56(1):55-65.

Marques, F.Z. et al. (2010) "The molecular basis of longevity, and clinical implications." Maturitas 65(2):87-91.

Tristan, T. (2010) "The aging raptor." Vet Clin North Am Exot Anim Pract 13(1):51-84.

Fagan, W.F. et al. (2010) "Pitfalls and challenges of estimating population growth rate from empirical data: consequences for allometric scaling relations." Oikos 119(3):455-464.

Page, M.M. et al. (2010) "Antioxidant enzyme activities are not broadly correlated with longevity in 14 vertebrate endotherm species." Age (Dordr) 32(2):255-270.

Kribs-Zaleta, C. et al. (2010) "Estimating contact process saturation in sylvatic transmission of Trypanosoma cruzi in the United States." PLoS Negl Trop Dis 4(4):e656.

Jobson, R.W. et al. (2010) "An evolutionary genome scan for longevity-related natural selection in mammals." Mol Biol Evol 27(4):840-847.

Lambert, A.J.. et al. (2010) "Low complex I content explains the low hydrogen peroxide production rate of heart mitochondria from the long-lived pigeon, Columba livia." Aging Cell 9(1):78-91.

Hackl, M. et al. (2010) "miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging." Aging Cell 9(2):291-296.

Fortney, K. et al. (2010) "Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegans aging." Genome Biol 11(2):R13.

González-Lagos, C. et al. (2010) "Large-brained mammals live longer." J Evol Biol 23(5):1064-1074.

Cevenini, E. et al. (2010) "Systems biology and longevity: an emerging approach to identify innovative anti-aging targets and strategies." Curr Pharm Des 16(7):802-813.

Tacutu, R. et al. (2010) "MicroRNA-regulated protein-protein interaction networks: how could they help in searching for pro-longevity targets?" Rejuvenation Res 13(2-3):373-377.

Muradian, K.K. et al. (2010) "NUMT ("new mighty") hypothesis of longevity." Rejuvenation Res 13(2-3):152-155.

Ricklefs, R.E. (2010) "Life-history connections to rates of aging in terrestrial vertebrates." Proc Natl Acad Sci U S A 107(22):10314-10319.

Robert, L. et al. (2010) "Genetic, epigenetic and posttranslational mechanisms of aging." Biogerontology 11(4):387-399.

Tacutu, R. et al. (2010) "The NetAge database: a compendium of networks for longevity, age-related diseases and associated processes." Biogerontology 11(4):513-522.

Chautard, E. et al. (2010) "Interaction networks as a tool to investigate the mechanisms of aging." Biogerontology 11(4):463-473.

Warnefors, M. et al. (2010) "Transposable elements: insertion pattern and impact on gene expression evolution in hominids." Mol Biol Evol 27(8):1955-1962.

Wyse, C.A. et al. (2010) "Association between mammalian lifespan and circadian free-running period: the circadian resonance hypothesis revisited." Biol Lett 6(5):696-698.

Seligmann, H. (2010) "Avoidance of antisense, antiterminator tRNA anticodons in vertebrate mitochondria." Biosystems 101(1):42-50.

Romiguier, J. et al. (2010) "Contrasting GC-content dynamics across 33 mammalian genomes: relationship with life-history traits and chromosome sizes." Genome Res 2020(8):1001-1009.

Speakman, J.R., and Król, E. (2010) "The heat dissipation limit theory and evolution of life histories in endotherms - time to dispose of the disposable soma theory?" Integr Comp Biol 50(5):793-807.

Kipper, S., and Kiefer, S. (2010) "Age related changes in birds' singing styles: on fresh tunes and fading voices?" Adv Study Behav 4177—118.

Vogt, G. (2010) "Suitability of the clonal marbled crayfish for biogerontological research: a review and perspective, with remarks on some further crustaceans." Biogerontology 11(6):643-669.

Houtkooper, R.H. et al. (2010) "Metabolic networks of longevity." Cell 142(1):9-14.

Somel, M. et al. (2010) "MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain." Genome Res 20(9):1207-1218.

Seligmann, H. (2010) "Undetected antisense tRNAs in mitochondrial genomes?" Biol Direct 5:39.

Fang, L.Q. et al. (2010) "Spatiotemporal trends and climatic factors of hemorrhagic fever with renal syndrome epidemic in Shandong Province, China." PLoS Negl Trop Dis 4(8):e789.

Chung, W.H. et al. (2010) "The role of genetic variants in human longevity." Ageing Res Rev 9(Suppl 1):S67-S78.

Cornwallis, C.K. et al. (2010) "Promiscuity and the evolutionary transition to complex societies." Nature 466(7309):969-972.

Jobson, R.W. et al. (2010) "Apparent longevity-related adaptation of mitochondrial amino acid content is due to nucleotide compositional shifts." Mitochondrion 10(5):540-547.

Weisbecker, V., and Goswami, A. (2010) "Brain size, life history, and metabolism at the marsupial/placental dichotomy." Proc Natl Acad Sci U S A 107(37):16216-16221.

Köhler, M., and Moyà-Solà, S. (2010) "Reply to Meiri and Raia: Small offspring size and fast life history all the way?" Proc Natl Acad Sci U S A 107(8):E28.

Stuart, J.A., and Page, M.M. (2010) "Plasma IGF-1 is negatively correlated with body mass in a comparison of 36 mammalian species." Mech Ageing Dev 131(9):591-598.

Neill, D. (2010) "A proposal in relation to a genetic control of lifespan in mammals." Ageing Res Rev 9(4):437-446.

Zhang, T. et al. (2010) "Correlation of life-history traits with the molecular diversity of bird nuclear coding elements." Evol. Ecol. Res. 12(8):987-994.

Fuellen, G. et al. (2010) "Bioinformatics in aging research: a workshop report." Rejuvenation Res 13(6):763-777.

Laschober, G.T. et al. (2010) "Identification of evolutionarily conserved genetic regulators of cellular aging." Aging Cell 9(6):1084-1097.

Kwon, J. et al. (2010) "Gerontome: a web-based database server for aging-related genes and analysis pipelines." BMC Genomics 11 Suppl 4S20.

Austad, S.N. (2010) "Cats, "rats," and bats: the comparative biology of aging in the 21st century." Integr Comp Biol 50(5):783-792.

Li, Y.H. et al. (2010) "Systematic analysis and prediction of longevity genes in Caenorhabditis elegans." Mech Ageing Dev 131(11-12):700-709.

Mustafina, O.E. et al. (2010) "[Polymorphism of cytokine genes and human longevity]." Adv Gerontol 23(3):339-345.

Salway, K.D. et al. (2011) "Enhanced protein repair and recycling are not correlated with longevity in 15 vertebrate endotherm species." Age (Dordr) 33(1):33-47.

Voituron, Y. et al. (2011) "Extreme lifespan of the human fish (Proteus anguinus): a challenge for ageing mechanisms." Biol Lett 7(1):105-107.

Lartillot N., and Poujol, R. (2011) "A phylogenetic model for investigating correlated evolution of substitution rates and continuous phenotypic characters." Mol Biol Evol 28(1):729-744.

Napolioni, V. et al. (2011) "Haptoglobin (HP) polymorphisms and human longevity: A cross-sectional association study in a Central Italy population." Clin Chim Acta 412(7-8):574-577.

Ahmed, S.S. et al. (2011) "Systems biological approach on neurological disorders: a novel molecular connectivity to aging and psychiatric diseases." BMC Syst Biol 56.

Ridgway, I.D. et al. (2011) "Maximum shell size, growth rate, and maturation age correlate with longevity in bivalve molluscs." J Gerontol A Biol Sci Med Sci 66(2):183-190.

Kuchaiev, O. et al. (2011) "GraphCrunch 2: Software tool for network modeling, alignment and clustering." BMC Bioinformatics 1224.

Miller, R.A. et al. (2011) "Comparative cellular biogerontology: primer and prospectus." Ageing Res. Rev. 10(2):181-190.

Bloss, C.S. et al. (2011) "Contemporary human genetic strategies in aging research." Ageing Res. Rev. 10(2):191-200.

Budovsky, A. et al. (2011) "Linking cell polarity, aging and rejuvenation." Biogerontology 12(2):167-175.

Kriete, A. et al. (2011) "Computational systems biology of aging." Wiley Interdiscip Rev Syst Biol Med 3(4):414-428.

Globerson, A., and Reznick, A.Z. (2011) "Biogerontology research in Israel." Biogerontology 12(1):17-30.

Turbill, C. et al. (2011) "Hibernation is associated with increased survival and the evolution of slow life histories among mammals." Proc. Biol. Sci. 278(1723):3355-3363.

Peysselon, F., and Ricard-Blum, S. (2011) "Understanding the biology of aging with interaction networks." Maturitas 69(2):126-130.

Gomes, N.M. et al. (2011) "Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination." Aging Cell 10(5):761-768.

Tacutu, R. et al. (2011) "Molecular links between cellular senescence, longevity and age-related diseases - a systems biology perspective." Aging (Albany NY) 3(12):1178-1191.

Austad, S.N., and Fischer, K.E. (2011) "The development of small primate models for aging research." ILAR J 52(1):78-88.

Fu, X. et al. (2011) "Rapid metabolic evolution in human prefrontal cortex." Proc. Natl. Acad. Sci. U.S.A. 108(15):6181-6186.

Funasaka, T. et al. (2011) "RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis." Cell Cycle 10(9):1456-1467.

Yanai, H. et al. (2011) "Is rate of skin wound healing associated with aging or longevity phenotype?" Biogerontology 12(6):591-597.

LePendu, P. et al. (2011) "Enabling enrichment analysis with the Human Disease Ontology." J Biomed Inform 44 Suppl 1:S31-S38.

Kato, M. et al. (2011) "Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans." RNA 17(10):1804-1820.

Salway, K.D. et al. (2011) "Higher levels of heat shock proteins in longer-lived mammals and birds." Mech. Ageing Dev. 132(6-7):287-297.

Wilson, D.M. et al. (2011) ""No one dies of old age": implications for research, practice, and policy." J Palliat Care 27(2):148-156.

Montgomery, M.K. et al. (2011) "The long life of birds: the rat-pigeon comparison revisited." PLoS ONE 6(8):e24138.

Van Raamsdonk, J.M., and Hekimi, S. (2011) "FUdR causes a twofold increase in the lifespan of the mitochondrial mutant gas-1." Mech. Ageing Dev. 132(10):519-521.

Jones, J.H. (2011) "Primates and the evolution of long, slow life histories." Curr. Biol. 21(18):R708-R717.

Rodriguez, KA. et al. (2011) "Walking the oxidative stress tightrope: a perspective from the naked mole-rat, the longest-living rodent." Curr. Pharm. Des. 17(22):2290-2307.

Yu, C. et al. (2011) "RNA sequencing reveals differential expression of mitochondrial and oxidation reduction genes in the long-lived naked mole-rat when compared to mice." PLoS ONE 6(11):e26729.

Jiang, H. and Ching, W.K. (2011) "Classifying DNA repair genes by kernel-based support vector machines." Bioinformation 7(5):257-263.

Lorenzini, A. et al. (2011) "Relationship of spindle assembly checkpoint fidelity to species body mass, lifespan, and developmental rate." Aging (Albany NY) 3(12):1206-1212.

Schmidt, M. and Derby, C.D. (2011) "Cytoarchitecture and ultrastructure of neural stem cell niches and neurogenic complexes maintaining adult neurogenesis in the olfactory midbrain of spiny lobsters, Panulirus argus." J. Comp. Neurol. 519(12):2283-2319.

Harper, J.M. et al. (2011) "Fibroblasts from long-lived bird species are resistant to multiple forms of stress." J. Exp. Biol. 214(Pt 11):1902-1910.

Hofer, E. et al. (2011) "GiSAO.db: a database for ageing research." BMC Genomics 12:262.

Mendenhall, A.R. et al. (2011) "Genetic dissection of late-life fertility in Caenorhabditis elegans." J. Gerontol. A Biol. Sci. Med. Sci. 66(8):842-854.

Delbarco-Trillo, J. (2011) "Adjustment of sperm allocation under high risk of sperm competition across taxa: a meta-analysis." J. Evol. Biol. 24(8):1706-1714.

Ungvari, Z. et al. (2011) "Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta." J. Gerontol. A Biol. Sci. Med. Sci. 66(8):866-875.

Walter, S. et al. (2011) "A genome-wide association study of aging." Neurobiol. Aging 32(11):2109.e15-2109.e28.

Napolioni, V. et al. (2011) "APOE haplotypes are associated with human longevity in a Central Italy population: evidence for epistasis with HP 1/2 polymorphism." Clin. Chim. Acta 412(19-20):1821-1824.

Seligmann, H. (2011) "Two genetic codes, one genome: frameshifted primate mitochondrial genes code for additional proteins in presence of antisense antitermination tRNAs." BioSystems 105(3):271-285.

Kitazoe, Y. et al. (2011) "Stability of mitochondrial membrane proteins in terrestrial vertebrates predicts aerobic capacity and longevity." Genome Biol Evol 3:1233-1244.

Milenković, T. et al. (2011) "Dominating biological networks." PLoS ONE 6(8):e23016.

Pierron, D. et al. (2011) "Silencing, positive selection and parallel evolution: busy history of primate cytochromes C." PLoS ONE 6(10):e26269.

Popov, IIu. (2011) "[Distribution of the different patterns of aging over the system of animal world]." Adv Gerontol 24(2):179-188.

Baudisch, A. (2011) "The pace and shape of ageing" Methods Ecol Evol 2(4):375-382.

Bourouiba, L. et al. (2011) "The interaction of Migratory Birds and Domestic Poultry and its role in sustaining Avian Influenza." AM J. Appl. Math. 71(2):487-516.

Tacutu, R. et al. (2011) "Immunoregulatory network and cancer-associated genes: molecular links and relevance to aging." Network Biol. 1(2):112-120.

Zhang, L., and Lu, X. (2012) "Amphibians live longer at higher altitudes but not at higher latitudes." Biol J Linn Soc 106(3):623-632.

Lartillot, N. and Delsuc, F. (2012) "Joint reconstruction of divergence times and life-history evolution in placental mammals using a phylogenetic covariance model." Evolution 66(6):1773-1787.

Mahdi, R.N. and Rouchka, E.C. (2012) "Codon usage bias as a function of generation time and life expectancy." Bioinformation 8(3):158-162.

Moskalev, A.A. et al. (2012) "Gadd45 proteins: relevance to aging, longevity and age-related pathologies." Ageing Res. Rev. 11(1):51-66.

Shi, H. et al. (2012) "Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS)." Neurobiol. Aging 33(8):1849.e5-1849.e18.

Vives I Batlle, J. (2012) "Dual-age-class population model to assess radiation dose effects on non-human biota populations." Radiat Environ Biophys 51(3):225-243.

Lazic, S.E. (2012) "Modeling hippocampal neurogenesis across the lifespan in seven species." Neurobiol. Aging 33(8):1664-1671.

Liu, X. et al. (2012) "Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques." Genome Res. 22(4):611-622.

Sazykina, T.G., and Kryshev, A.I. (2012) "Radiation effects in generic populations inhabiting a limiting environment." Radiat Environ Biophys 51(2):215-221.

Montgomery, M.K. et al. (2012) "Does the oxidative stress theory of aging explain longevity differences in birds? II. Antioxidant systems and oxidative damage." Exp. Gerontol. 47(3):211-222.

Kirschner, J. et al. (2012) "Mapping of quantitative trait loci controlling lifespan in the short-lived fish Nothobranchius furzeri--a new vertebrate model for age research." Aging Cell 11(2):252-261.

Pilling, LC. et al. (2012) "Genomics and successful aging: grounds for renewed optimism?" J. Gerontol. A Biol. Sci. Med. Sci. 67(5):511-519.

Zhou, B. et al. (2012) "Midlife gene expressions identify modulators of aging through dietary interventions." Proc. Natl. Acad. Sci. U.S.A. 109(19):E1201-E1209.

Montgomery, MK. et al. (2012) "Does the oxidative stress theory of aging explain longevity differences in birds? I. Mitochondrial ROS production." Exp. Gerontol. 47(3):203-210.

Edrey, YH. et al. (2012) "Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity." Aging Cell 11(2):213-222.

Dammann, P. et al. (2012) "Advanced glycation end-products as markers of aging and longevity in the long-lived Ansell's mole-rat (Fukomys anselli)." J. Gerontol. A Biol. Sci. Med. Sci. 67(6):573-583.

Csiszar, A. et al. (2012) "Age-Associated Proinflammatory Secretory Phenotype in Vascular Smooth Muscle Cells From the Non-human Primate Macaca mulatta: Reversal by Resveratrol Treatment." J. Gerontol. A Biol. Sci. Med. Sci. 67(8):811-820.

Csiszar, A. et al. (2012) "Testing the Oxidative Stress Hypothesis of Aging in Primate Fibroblasts: Is There a Correlation Between Species Longevity and Cellular ROS Production?" J. Gerontol. A Biol. Sci. Med. Sci. 67(8):841-852.

Huang, T. et al. (2012) "Deciphering the effects of gene deletion on yeast longevity using network and machine learning approaches." Biochimie 94(4):1017-1025.

Montgomery, M.K. et al. (2012) "Metabolic rate and membrane fatty acid composition in birds: a comparison between long-living parrots and short-living fowl." J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. 182(1):127-137.

Lebel, M. et al. (2012) "Drugs, nutrients, and phytoactive principles improving the health span of rodent models of human age-related diseases." J. Gerontol. A Biol. Sci. Med. Sci. 67(2):140-151.

Guterl, F. (2012) "Which creatures live the longest? The key indicator for animals may be total energy expended over a lifetime." Sci Am. 307(3):96.

Moorad, JA. et al. (2012) "A comparative assessment of univariate longevity measures using zoological animal records." Aging Cell 11(6):940-948.

Page, M.M. and Stuart, J.A. (2012) "Activities of DNA base excision repair enzymes in liver and brain correlate with body mass, but not lifespan." Age (Dordr) 34(5):1195-1209.

Finch, C.E. and Austad, S.N. (2012) "Primate aging in the mammalian scheme: the puzzle of extreme variation in brain aging." Age (Dordr) 34(5):1075-1091.

Deweerdt, S. (2012) "Comparative biology: Looking for a master switch." Nature 492(7427):S10-S11.

Semeiks, J. and Grishin, N.V. (2012) "A method to find longevity-selected positions in the mammalian proteome." PLoS ONE 7(6):e38595.

Seligmann, H. (2012) "Putative mitochondrial polypeptides coded by expanded quadruplet codons, decoded by antisense tRNAs with unusual anticodons." BioSystems 110(2):84-8106.

Gorbunova, V. et al. (2012) "Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism." Proc. Natl. Acad. Sci. U.S.A. 109(47):19392-19396.

Werner, J. and Griebeler, E. (2012) "Reproductive investment in moa: a K-selected life-history strategy?" Evol. Ecol. 26:1391-1419.

Herrando-Pérez, S. et al. (2012) "Strength of density feedback in census data increases from slow to fast life histories." Ecol. Evol. 2(8):1922-1934.

Song, X. et al. (2012) "Discovering aging-genes by topological features in Drosophila melanogaster protein-protein interaction network." 2012 IEEE 12th International Conference on Data Mining Workshops pp.94-98.

Li, Y.-H. et al. (2012) "Discovering aging-genes by topological features in Drosophila melanogaster protein-protein interaction network." IJKDB 3(2):16-26.

Carney Almroth, B. et al. (2012) "Oxidative stress in growth hormone transgenic coho salmon with compressed lifespan--a model for addressing aging." Free Radic. Res. 46(10):1183-1189.

Fuellen, G. et al. (2012) "Systems biology and bioinformatics in aging research: a workshop report." Rejuvenation Res 15(6):631-641.

Bro-Jørgensen, J. (2012) "Longevity in bovids is promoted by sociality, but reduced by sexual selection." PLoS ONE 7(9):e45769.

Taranukha, D. et al. (2012) "Co-regulation of polar mRNA transport and lifespan in budding yeast Saccharomyces cerevisiae." Cell Cycle 11(22):4275-4280.

Erten-Lyons, D. et al. (2012) "Review of selected databases of longitudinal aging studies." Alzheimers Dement 8(6):584-589.

Irisarri, I. et al. (2012) "The origin of modern frogs (Neobatrachia) was accompanied by acceleration in mitochondrial and nuclear substitution rates." BMC Genomics 13:626.

Tacutu, R. et al. (2012) "Prediction of C. elegans longevity genes by human and worm longevity networks." PLoS ONE 7(10):e48282.

Shah, N.H. et al. (2012) "Chapter 9: Analyses using disease ontologies." PLoS Comput. Biol. 8(12):e1002827.

Vives I Batlle, J. et al. (2012) "Inter-comparison of population models for the calculation of radiation dose effects on wildlife." Radiat Environ Biophys 51(4):399-410.

Azpurua, J. and Seluanov, A. (2012) "Long-lived cancer-resistant rodents as new model species for cancer research." Front Genet 3:319.

Luis, A.D. et al. (2013) "A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special?" Proc. Biol. Sci. 280(1756):20122753.

Pampush, J.D. et al. (2013) "Homoplasy and thick enamel in primates." J. Hum. Evol. 64(3):216-224.

Martinez-Zubiaurre, I. et al. (2013) "Tumorigenic Responses of Cancer-Associated Stromal Fibroblasts after Ablative Radiotherapy: A Transcriptome-Profiling Study." Journal of Cancer Therapy 4(1):208-250.

Novikov, E.A. and Burda, G. (2013) "Ecological and evolutionary preconditions of extended longevity in subterranean rodents." Biology Bulletin Reviews 3(4):325-333.

Kopecký, O. et al. (2013) "Ecological and evolutionary preconditions of extended longevity in subterranean rodents." Knowl. Managt. Aquatic Ecosyst. (410):02.

Rahman, A.A. et al. (2013) "Senescence-related changes in gene expression of peripheral blood mononuclear cells from octo/nonagenarians compared to their offspring." Oxidative Medicine and Cellular Longevity 2013:189129.

Vaiserman, A.M. et al. (2013) "Geroprotective potential of sodium butyrate in Drosophila melanogaster: Long-term effects." Adv. Gerontol. 3(4):297-301.

Pacifici, M. et al. (2013) "Generation length for mammals." Nature Conservation 5:87–94.

Stuart, J.A. et al. (2013) "A comparative cellular and molecular biology of longevity database." Age (Dordr) 35(5):1937-1947.

Wilder, S.M. et al. (2013) "Diet mediates the relationship between longevity and reproduction in mammals." Age (Dordr) 35(3):921-927.

Moskalev, A.A. et al. (2013) "The role of DNA damage and repair in aging through the prism of Koch-like criteria." Ageing Res. Rev. 12(2):661-684.

Di Cianni, F. et al. (2013) "MAP3K7 and GSTZ1 are associated with human longevity: a two-stage case-control study using a multilocus genotyping." Age (Dordr) 35(4):1357-1366.

Baskurt, O.K. and Meiselman, H.J. (2013) "Comparative hemorheology." Clin. Hemorheol. Microcirc. 53(1-2):61-70.

Yang, J.N. et al. (2013) "Mitochondrial inverted repeats strongly correlate with lifespan: mtDNA inversions and aging." PLoS ONE 8(9):e73318.

Muller, M. and Groothuis, T.G. (2013) "Within-clutch variation in yolk testosterone as an adaptive maternal effect to modulate avian sibling competition: evidence from a comparative study." Am. Nat. 181(1):125-136.

Nussey, D.H. et al. (2013) "Senescence in natural populations of animals: widespread evidence and its implications for bio-gerontology." Ageing Res. Rev. 12(1):214-225.

Romiguier, J. et al. (2013) "Genomic evidence for large, long-lived ancestors to placental mammals." Mol. Biol. Evol. 30(1):5-13.

Lourenco, J.M. et al. (2013) "The determinants of the molecular substitution process in turtles." J. Evol. Biol. 26(1):38-50.

Barrett, E.L. et al. (2013) "Telomere length and dynamics predict mortality in a wild longitudinal study." Mol. Ecol. 22(1):249-259.

Brown, K. et al. (2013) "SIRT3 reverses aging-associated degeneration." Cell Rep 3(2):319-327.

Wang, X. (2013) "Discovery of molecular associations among aging, stem cells, and cancer based on gene expression profiling." Chin J Cancer 32(4):155-161.

Deelen, J. et al. (2013) "Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges." Bioessays 35(4):386-396.

Phillips, M.J. et al. (2013) "Inferring kangaroo phylogeny from incongruent nuclear and mitochondrial genes." PLoS ONE 8(2):e57745.

Magrassi, L. et al. (2013) "Lifespan of neurons is uncoupled from organismal lifespan." Proc. Natl. Acad. Sci. U.S.A. 110(11):4374-4379.

Mocchegiani, E. et al. (2013) "Metallothioneins, ageing and cellular senescence: a future therapeutic target." Curr. Pharm. Des. 19(9):1753-1764.

Garnier, R. et al. (2013) "Evolution of the temporal persistence of immune protection." Biol. Lett. 9(3):20130017.

Monte, L. (2013) "Predicting the effect of ionising radiation on biological populations: testing of a non-linear Leslie model applied to a small mammal population." J Environ Radioact 122:63-69.

Shaffer, H.B. et al. (2013) "The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage." Genome Biol. 14(3):R28.

Azpurua, J. et al. (2013) "IGF1R levels in the brain negatively correlate with longevity in 16 rodent species." Aging (Albany NY) 5(4):304-314.

Chedraui, P. and Pérez-López, F.R. (2013) "Nutrition and health during mid-life: searching for solutions and meeting challenges for the aging population." Climacteric 16 Suppl 1:85-95.

Nabholz, B. et al. (2013) "Reconstructing the phylogenetic history of long-term effective population size and life-history traits using patterns of amino acid replacement in mitochondrial genomes of mammals and birds." Genome Biol Evol 5(7):1273-1290.

Lehmann, G. et al. (2013) "Telomere length and body temperature-independent determinants of mammalian longevity?" Front Genet 4:111.

Porto, A. et al. (2013) "Size variation, growth strategies, and the evolution of modularity in the Mammalian skull." Evolution 67(11):3305-3322.

Li, Y. et al. (2013) "Characterizing genes with distinct methylation patterns in the context of protein-protein interaction network: application to human brain tissues." PLoS ONE 8(6):e65871.

Anvar, S.Y. et al. (2013) "A decline in PABPN1 induces progressive muscle weakness in oculopharyngeal muscle dystrophy and in muscle aging." Aging (Albany NY) 5(6):412-426.

Laurijssens, B. et al. (2013) "Animal models of Alzheimer's disease and drug development." Drug Discov Today Technol 10(3):e319-e327.

Sharma, A. et al. (2013) "The protein-protein interaction network of the human Sirtuin family." Biochim. Biophys. Acta 1834(10):1998-2009.

Pastrello, C. et al. (2013) "Visual data mining of biological networks: one size does not fit all." PLoS Comput. Biol. 9(1):e1002833.

Morgan, C.C. et al. (2013) "Heterogeneous models place the root of the placental mammal phylogeny." Mol. Biol. Evol. 30(9):2145-2156.

Romani, W.A. and Russ, D.W. (2013) "Acute effects of sex-specific sex hormones on heat shock proteins in fast muscle of male and female rats." Eur. J. Appl. Physiol. 113(10):2503-2510.

Tian, X. et al. (2013) "High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat." Nature 499(7458):346-349.

O'Connor, T.D. and Mundy, N.I. (2013) "Evolutionary Modeling of Genotype-Phenotype Associations, and Application to Primate Coding and Non-coding mtDNA Rate Variation." Evol. Bioinform. Online 9:301-316.

Wolf, A. et al. (2013) "Lateral diffusion of nutrients by mammalian herbivores in terrestrial ecosystems." PLoS ONE 8(8):e71352.

Benoit, J. et al. (2013) "New insights into the ear region anatomy and cranial blood supply of advanced stem Strepsirhini: evidence from three primate petrosals from the Eocene of Chambi, Tunisia." J. Hum. Evol. 65(5):551-572.

West, J. et al. (2013) "Distinctive topology of age-associated epigenetic drift in the human interactome." Proc. Natl. Acad. Sci. U.S.A. 110(35):14138-14143.

Garratt, M. et al. (2013) "Diversification of the eutherian placenta is associated with changes in the pace of life." Proc. Natl. Acad. Sci. U.S.A. 110(19):7760-7765.

Danilov, A. et al. (2013) "Selective anticancer agents suppress aging in Drosophila." Oncotarget 4(9):1507-1526.

Gasca-Pineda, J. et al. (2013) "Effective population size, genetic variation, and their relevance for conservation: the bighorn sheep in tiburon island and comparisons with managed artiodactyls." PLoS ONE 8(10):e78120.

Schaible, R. and Sussman, M. (2013) "FOXO in aging: Did evolutionary diversification of FOXO function distract it from prolonging life?" Bioessays 35(12):1101-1110.

Glass, D. et al. (2013) "Gene expression changes with age in skin, adipose tissue, blood and brain." Genome Biol. 14(7):R75.

Morgan, CC. et al. (2013) "Molecular adaptation of telomere associated genes in mammals." BMC Evol. Biol. 13(1):251.

Gonzalez-Covarrubias, V. (2013) "Lipidomics in longevity and healthy aging." Biogerontology 14(6):663-672.

Muradian, K. (2013) ""Pull and push back" concepts of longevity and life span extension." Biogerontology 14(6):687-691.

Gentschew, L. et al. (2013) "Polymorphisms in the superoxidase dismutase genes reveal no association with human longevity in Germans: a case-control association study." Biogerontology 14(6):719-727.

Fuellen, G. et al. (2013) "In silico approaches and the role of ontologies in aging research." Rejuvenation Res 16(6):540-546.

Doughty, C.E. et al. (2013) "The impact of large animal extinctions on nutrient fluxes in early river valley civilizations." Ecosphere 4(12):art148.

Holt, D.E. et al. (2013) "Movement and longevity of imperiled Okaloosa Darters (Etheostoma okaloosae)." Ecosphere 2013(4):653-659.

Castillo-Morales, A. et al. (2014) "Increased brain size in mammals is associated with size variations in gene families with cell signalling, chemotaxis and immune-related functions." Proc. Biol. Sci. 281(1775):20132428.

Hulbert, A.J. et al. (2014) "Polyunsaturated fats, membrane lipids and animal longevity." J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. 184(2):149-166.

Schneider, T.C. and Kappeler, P.M. (2014) "Social systems and life-history characteristics of mongooses." Biol Rev Camb Philos Soc 89(1):173-198.

Ong, M.L. and Holbrook, J.D. (2014) "Novel region discovery method for Infinium 450K DNA methylation data reveals changes associated with aging in muscle and neuronal pathways." Aging Cell 13(1):142-155.

van den Akker, E.B. et al. (2014) "Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging." Aging Cell 13(2):216-225.

Kalathur, R.K. et al. (2014) "UniHI 7: an enhanced database for retrieval and interactive analysis of human molecular interaction networks." Nucleic Acids Res. 42(Database issue):D408-D414.

Elbourkadi, N. et al. (2014) "Fibroblasts from long-lived species of mammals and birds show delayed, but prolonged, phosphorylation of ERK." Aging Cell 13(2):283-291.

Yapuncich, G.S. and Boyer, D.M. (2014) "Interspecific scaling patterns of talar articular surfaces within primates and their closest living relatives." J. Anat. 224(2):150-172.

Ludewig, A.H. et al. (2014) "Identifying evolutionarily conserved genes in the dietary restriction response using bioinformatics and subsequent testing in Caenorhabditis elegans." Genes Nutr 9(1):363.

Fok, W.C. et al. (2014) "Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver." Aging Cell 13(2):311-319.

Huhne, R. et al. (2014) "AgeFactDB--the JenAge Ageing Factor Database--towards data integration in ageing research." Nucleic Acids Res. 42(Database issue):D892-D896.

Zhao, G. et al. (2014) "Evolution of human longevity uncoupled from caloric restriction mechanisms." PLoS ONE 9(1):e84117.

Evans, S.E. et al. (2014) "New material of beelzebufo, a hyperossified frog (amphibia: anura) from the late cretaceous of madagascar." PLoS ONE 9(1):e87236.

Bekaert, M. and Conant, G.C. (2014) "Gene duplication and phenotypic changes in the evolution of Mammalian metabolic networks." PLoS ONE 9(1):e87115.

Kulminski, A.M. et al. (2014) "Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan." PLoS Genet. 10(1):e1004141.

NEW REFS:

Moncunill-Solé, B. et al. (2014) "How large are the extinct giant insular rodents? New body mass estimations from teeth and bones." Integr Zool 9(2):197-212.

Tackney, J. et al. (2014) "Blood cell telomere lengths and shortening rates of chimpanzee and human females." Am. J. Hum. Biol. 26(4):452-460.

Mariadassou, M. and Pellay, F.X. (2014) "Identification of amino acids in mitochondrially encoded proteins that correlate with lifespan." Exp. Gerontol. 56:53-58.

Di Marco, M. et al. (2014) "Drivers of extinction risk in African mammals: the interplay of distribution state, human pressure, conservation response and species biology." Philos. Trans. R. Soc. Lond., B, Biol. Sci. 369(1643):20130198.

Healy, K. et al. (2014) "Ecology and mode-of-life explain lifespan variation in birds and mammals." Proc. Biol. Sci. 281(1784):20140298.

Figuet, E. et al. (2014) "Mitochondrial DNA as a tool for reconstructing past life-history traits in mammals." J. Evol. Biol. 27(5):899-910.

Al-Ahmed, A. et al. (2014) "Chewing lice (Phthiraptera: Amblycera, Ischnocera) from Red Sea gulls with new host-parasite records." Zootaxa 3790:567-576.

Rottenberg, H. (2014) "Exceptional longevity and exceptionally high metabolic rates in anthropoid primates are linked to a major modification of the ubiquinone reduction site of cytochrome b." J. Bioenerg. Biomembr. 46(5):435-445.

Lukas, D. and Clutton-Brock, T. (2014) "Costs of mating competition limit male lifetime breeding success in polygynous mammals." Proc. Biol. Sci. 281(1786):20140418.

Runkel, E.D. et al. (2014) "Mitochondrial stress: balancing friend and foe." Exp. Gerontol. 56:194-201.

Di Marco, M. et al. (2014) "Drivers of extinction risk in African mammals: the interplay of distribution state, human pressure, conservation response and species biology." Philos. Trans. R. Soc. Lond., B, Biol. Sci. 369(1643):20130198.

Pontzer, H. et al. (2014) "Primate energy expenditure and life history." Proc. Natl. Acad. Sci. U.S.A. 111(4):1433-1437.

Bize, P. et al. (2014) "Senescence in cell oxidative status in two bird species with contrasting life expectancy." Oecologia 174(4):1097-1105.

Tiwari, S. et al. (2014) "Isolation, structure determination, and antiaging effects of 2,3-pentanediol from endophytic fungus of Curcuma amada and docking studies." Protoplasma 251(5):1089-1098.

Freedberg, S. and Debenport, S.J. (2014) "Weakened purifying selection leads to elevated mutation load under environmental sex determination." J. Evol. Biol. 27(3):643-652.

Wong, A. (2014) "Covariance between testes size and substitution rates in primates." Mol. Biol. Evol. 31(6):1432-1436.

Ayyadevara, S. et al. (2014) "Rec-8 dimorphism affects longevity, stress resistance and X-chromosome nondisjunction in C. elegans, and replicative lifespan in S. cerevisiae." Front Genet 5:211.

Valencak, T.G. and Azzu, V. (2014) "Making heads or tails of mitochondrial membranes in longevity and aging: a role for comparative studies." Longev Healthspan 3(1):3.

Yoldas, A. et al. (2014) "Macroscopic distribution of the renal artery and intrarenal arteries in mole rats (Spalax leucodon)." Veterinarni Medicina 59:382-387.

Mudhir, S.H. et al. (2014) "Salivary microRNAs (hsa-miR-200a, hsa-miR-125a and hsa- miR-93) in relation to age, gender and histopathological parameters." Journal of Baghdad College of Dentistry 26(4):120-125.

Gorbunova, V. et al. (2014) "Comparative genetics of longevity and cancer: insights from long-lived rodents." Nat. Rev. Genet. 15(8):531-540.

Bao, Q. et al. (2014) "Aging and age-related diseases--from endocrine therapy to target therapy." Mol. Cell. Endocrinol. 394(1-2):115-118.

Davies, K.T. et al. (2014) "Molecular evolution of growth hormone and insulin-like growth factor 1 receptors in long-lived, small-bodied mammals." Gene 549(2):228-236.

Zhavoronkov, A. et al. (2014) "Signaling pathway cloud regulation for in silico screening and ranking of the potential geroprotective drugs." Front Genet 5:49.

Faner, R. et al. (2014) "Network medicine, multimorbidity and the lung in the elderly." Eur. Respir. J. 44(3):775-788.

Cash, T.P. et al. (2014) "Exome sequencing of three cases of familial exceptional longevity." Aging Cell 13(6):1087-1090.

Pistilli, E.E. et al. (2014) "Aging alters contractile properties and fiber morphology in pigeon skeletal muscle." J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. 184(8):1031-1039.

Corella, D. and Ordovás, J.M. (2014) "Aging and cardiovascular diseases: the role of gene-diet interactions." Ageing Res. Rev. 18:53-73.

Walls, S. (2014) "Identifying monitoring gaps for amphibian populations in a North American biodiversity hotspot, the southeastern USA." Biodiversity and Conservation 23(13):3341-3357.

Valcu, M. et al. (2014) "Global gradients of avian longevity support the classic evolutionary theory of ageing." Ecography 37(10):930-938.

Kopyl, S. A. et al. (2014) "Role of tumor suppressor genes in aging and longevity mechanisms in Drosophila melanogaster." Russian Journal of Genetics: Applied Research 4(1):8-14.

Lemaître, J.-F. et al. (2014) "A test of the metabolic theory of ecology with two longevity data sets reveals no common cause of scaling in biological times." Mammal Review 44(3-4):204-214.

Marín-Moratalla, N. et al. (2014) "Correlation of quantitative bone histology data with life history and climate: a phylogenetic approach." Biological Journal of the Linnean Society 112(4):678-687.

D'Ambrosia, A.R. et al. (2014) "Stable isotope patterns found in early Eocene equid tooth rows of North America: Implications for reproductive behavior and paleoclimate." Palaeogeography, Palaeoclimatology, Palaeoecology 414:310-319.

Baylis, S.M. et al. (2014) "Inferring maximum lifespan from maximum recorded longevity in the wild carries substantial risk of estimation bias." Ecography 37(8):770-780.

Beaulieu, M., and Sockman, K. W. (2014) "Comparison of optimal foraging versus life-history decisions during nestling care in Lincoln's Sparrows Melospiza lincolnii through stable isotope analysis." Ibis 156(2):424-432.

Dávalos, L.M., and Russell, A.L. (2014) "Sex-biased dispersal produces high error rates in mitochondrial distance-based and tree-based species delimitation." Journal of Mammalogy 95(4):781-791.

Farias, A., and Svensson, G. (2014) "Ecoregional Vulnerability Assessment for the Functional Richness of South American Carnivorans (Mammalia: Carnivora)." Journal of Mammalian Evolution 21(4):437-450.

Guarino, F.M. et al. (2014) "Huge but moderately long-lived: age structure in the mountain chicken, Leptodactylus fallax, from Montserrat, West Indies." The Herpetological Journal 24(3):167-173.

Evfratov, S.A. et al. (2014) "Structural Features of the Telomerase RNA Gene in the Naked Mole Rat Heterocephalus glaber." Acta Naturae 6(2):41-47.

Ostfeld, R.S. et al. (2014) "Life history and demographic drivers of reservoir competence for three tick-borne zoonotic pathogens." PLoS ONE 9(9):e107387.

Swanson, E.M. and Dantzer, B. (2014) "Insulin-like growth factor-1 is associated with life-history variation across Mammalia." Proc. Biol. Sci. 281(1782):20132458.

Frías-Alvarez, P. et al. (2014) "Spatial and temporal variation in superfoetation and related life history traits of two viviparous fishes: Poeciliopsis gracilis and P. infans." Naturwissenschaften 101(12):1085-1098.

Moni, M.A. and Liò, P. (2014) "Network-based analysis of comorbidities risk during an infection: SARS and HIV case studies." BMC Bioinformatics 15:333.

Pandit, A. et al. (2014) "PHA-4/FOXA-regulated microRNA feed forward loops during Caenorhabditis elegans dietary restriction." Aging (Albany NY) 6(10):835-855.

Sidler, C. et al. (2014) "SUV39H1 downregulation induces deheterochromatinization of satellite regions and senescence after exposure to ionizing radiation." Front Genet 5:411.

Tidière, M. et al. (2014) "Males do not senesce faster in large herbivores with highly seasonal rut." Exp. Gerontol. 60:167-172.

Cao, Q. et al. (2014) "New allometric scaling relationships and applications for dose and toxicity extrapolation." Int. J. Toxicol. 33(6):482-489.

Romiguier, J. et al. (2014) "Comparative population genomics in animals uncovers the determinants of genetic diversity." Nature 515(7526):261-263.

Faisal, F.E. and Milenković, T. (2014) "Dynamic networks reveal key players in aging." Bioinformatics 30(12):1721-1729.

Goodenberger, K.E. et al. (2015) "Functional morphology of the hallucal metatarsal with implications for inferring grasping ability in extinct primates." Am. J. Phys. Anthropol. 156(3):327-348.

Sagi, O. et al. (2015) "ShcC proteins: brain aging and beyond." Ageing Res. Rev. 19:34-42.

Dostál, L. et al. (2015) "Fibroblasts from long-lived rodent species exclude cadmium." J. Gerontol. A Biol. Sci. Med. Sci. 70(1):10-19.

Novikov, E. et al. (2015) "Reproduction, aging and mortality rate in social subterranean mole voles (Ellobius talpinus Pall.)." Biogerontology 16(6):723-732.

Blumstein, D.T. et al. (2015) "The evolution of capture myopathy in hooved mammals: a model for human stress cardiomyopathy?" Evol Med Public Health 2015(1):195-203.

Concetti, F. et al. (2015) "The functional polymorphism rs73598374:G>A (p.Asp8Asn) of the ADA gene is associated with telomerase activity and leukocyte telomere length." Eur. J. Hum. Genet. 23(2):267-270.

Morris, B.J. et al. (2015) "Genetic analysis of TOR complex gene variation with human longevity: a nested case-control study of American men of Japanese ancestry." J. Gerontol. A Biol. Sci. Med. Sci. 70(2):133-142.

Pickering, A.M. et al. (2015) "Fibroblasts From Longer-Lived Species of Primates, Rodents, Bats, Carnivores, and Birds Resist Protein Damage." J. Gerontol. A Biol. Sci. Med. Sci. 70(7):791-799.

Thieme, R. et al. (2015) "Analysis of Alpha-2 Macroglobulin from the Long-Lived and Cancer-Resistant Naked Mole-Rat and Human Plasma." PLoS ONE 10(6):e0130470.

Du, W.W. et al. (2015) "The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence by targeting Par4." J. Cell. Sci. 128(2):293-304.

Kryshev, A.I. and Sazykina, T.G. (2015) "Modelling the effects of ionizing radiation on survival of animal population: acute versus chronic exposure." Radiat Environ Biophys 54(1):103-109.

Di Marco, M. and Santini, L. (2015) "Human pressures predict species' geographic range size better than biological traits." Glob Chang Biol 21(6):2169-2178.

Nickles, D. et al. (2015) "Whole genome sequences of 2 octogenarians with sustained cognitive abilities." Neurobiol. Aging 36(3):1435-1438.

Williams, S.A. and Shattuck, M.R. (2015) "Ecology, longevity and naked mole-rats: confounding effects of sociality?" Proc. Biol. Sci. 282(1802):20141664.

Robert, A. et al. (2015) "Actuarial senescence can increase the risk of extinction of mammal populations." Ecol Appl 25(1):116-124.

Ross, C. et al. (2015) "A structured population model suggests that long life and post-reproductive lifespan promote the evolution of cooperation." J. Theor. Biol. 369:85-94.

Fushan, AA. et al. (2015) "Gene expression defines natural changes in mammalian lifespan." Aging Cell 14(3):352-365.

Davies, KT. et al. (2015) "Family Wide Molecular Adaptations to Underground Life in African Mole-Rats Revealed by Phylogenomic Analysis." Mol. Biol. Evol. 32(12):3089-3107.

Rodriguez, M. et al. (2015) "Parkinson's disease as a result of aging." Aging Cell 14(3):293-308.

Callahan, A. et al. (2015) "An evidence-based approach to identify aging-related genes in Caenorhabditis elegans." BMC Bioinformatics 16:40.

Harel, I. et al. (2015) "A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate." Cell 160(5):1013-1026.

Yuan, T. et al. (2015) "An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging." PLoS Genet. 11(2):e1004996.

Bacalini, M.G. et al. (2015) "A meta-analysis on age-associated changes in blood DNA methylation: results from an original analysis pipeline for Infinium 450k data." Aging (Albany NY) 7(2):97-109.

Maciak, S. and Michalak, P. (2015) "Cell size and cancer: a new solution to Peto's paradox?" Evol Appl 8(1):2-8.

Lee, A.H. and Simons, E.L. (2015) "Wing bone laminarity is not an adaptation for torsional resistance in bats." PeerJ 3:e823.

Boyer, D.M. et al. (2015) "Evolution of postural diversity in primates as reflected by the size and shape of the medial tibial facet of the talus." Am. J. Phys. Anthropol. 157(1):134-177.

Lindborg, C.M. et al. (2015) "Conservation of pro-longevity genes among mammals." Mech. Ageing Dev. 146-148:23-27.

Wei, Y.N. et al. (2015) "Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging." Genome Biol. 16:41.

Yapuncich, G.S. et al. (2015) "Predicting euarchontan body mass: A comparison of tarsal and dental variables." Am. J. Phys. Anthropol. 157(3):472-506.

Smith, J. et al. (2015) "A budding yeast's perspective on aging: the shape I'm in." Exp. Biol. Med. (Maywood) 240(6):701-710.

Lakshmanan, L.N. et al. (2015) "Are mutagenic non D-loop direct repeat motifs in mitochondrial DNA under a negative selection pressure?" Nucleic Acids Res. 43(8):4098-4108.

Berenstein, A.J. et al. (2015) "Mining the modular structure of protein interaction networks." PLoS ONE 10(4):e0122477.

Pickering, A.M. et al. (2015) "Lifespan of mice and primates correlates with immunoproteasome expression." J. Clin. Invest. 125(5):2059-2068.

Faulkes, C.G. et al. (2015) "Molecular evolution of the hyaluronan synthase 2 gene in mammals: implications for adaptations to the subterranean niche and cancer resistance." Biol. Lett. 11(5):20150185.

Kim, S. et al. (2015) "Non-coding genomic regions possessing enhancer and silencer potential are associated with healthy aging and exceptional survival." Oncotarget 6(6):3600-3612.

Kolb, C. et al. (2015) "Growth in fossil and extant deer and implications for body size and life history evolution." BMC Evol. Biol. 15:19.

Baur, J. et al. (2015) "The MARK-AGE extended database: data integration and pre-processing." Mech. Ageing Dev. 151:31-37.

Baur, J. et al. (2015) "MARK-AGE data management: Cleaning, exploration and visualization of data." Mech. Ageing Dev. 151:38-44.

McGaugh, S.E. et al. (2015) "Rapid molecular evolution across amniotes of the IIS/TOR network." Proc. Natl. Acad. Sci. U.S.A. 112(22):7055-7060.

Carlson, K.A. et al. (2015) "Genome-Wide Gene Expression in relation to Age in Large Laboratory Cohorts of Drosophila melanogaster." Genet Res Int 2015:835624.

Barbour, A.G. et al. (2015) "Association between body size and reservoir competence of mammals bearing Borrelia burgdorferi at an endemic site in the northeastern United States." Parasit Vectors 8:299.

Caulin, A.F. et al. (2015) "Solutions to Peto's paradox revealed by mathematical modelling and cross-species cancer gene analysis." Philos. Trans. R. Soc. Lond., B, Biol. Sci. 370(1673):20140222.

Beaulieu, M. et al. (2015) "Reproduction alters oxidative status when it is traded-off against longevity." Evolution 69(7):1786-1796.

Song, F. et al. (2015) "Alzheimer's Disease: Genomics and Beyond." Int. Rev. Neurobiol. 121:1-24.

Kamilar, J.M. and Tecot, S.R. (2015) "Connecting proximate mechanisms and evolutionary patterns: pituitary gland size and mammalian life history." J. Evol. Biol. 28(11):1997-2008.

Bochaton, C. et al. (2015) "Body location and tail regeneration effects on osteoderms morphology-are they useful tools for systematic, paleontology, and skeletochronology in diploglossine lizards (squamata, anguidae)?" J. Morphol. 276(11):1333-1344.

Calhoon, E.A. et al. (2015) "Perspectives on the membrane fatty acid unsaturation/pacemaker hypotheses of metabolism and aging." Chem. Phys. Lipids 191:48-60.

Capellini, I. et al. (2015) "The role of life history traits in mammalian invasion success." Ecol. Lett. 18(10):1099-1107.

Galván, I. et al. (2015) "Long lifespans have evolved with long and monounsaturated fatty acids in birds." Evolution 69(10):2776-2784.

Kogan, V. et al. (2015) "Stability analysis of a model gene network links aging, stress resistance, and negligible senescence." Sci Rep 5:13589.

Cortie, C.H. et al. (2015) "Of mice, pigs and humans: An analysis of mitochondrial phospholipids from mammals with very different maximal lifespans." Exp. Gerontol. 70:135-143.

von Wyschetzki, K. et al. (2015) "Transcriptomic Signatures Mirror the Lack of the Fecundity/Longevity Trade-Off in Ant Queens." Mol. Biol. Evol. 32(12):3173-3185.

Moskalev, A. et al. (2015) "Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease." Aging (Albany NY) 7(9):616-628.

Jarman, S.N. et al. (2015) "Molecular biomarkers for chronological age in animal ecology." Mol. Ecol. 24(19):4826-4847.

Abegglen, L.M. et al. (2015) "Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans." JAMA 314(17):1850-1860.

Su, J. et al. (2015) "A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging." Skelet Muscle 5:35.

Szekely, P. et al. (2015) "The Mass-Longevity Triangle: Pareto Optimality and the Geometry of Life-History Trait Space." PLoS Comput. Biol. 11(10):e1004524.

Akhtarkhavari, T. et al. (2015) "Genetic Investigation of an Iranian Supercentenarian by Whole Exome Sequencing." Arch Iran Med 18(10):688-697.

Ma, S. et al. (2015) "Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity." Cell Rep 13(7):1319-1326.

Kolb, C. et al. (2015) "Mammalian bone palaeohistology: a survey and new data with emphasis on island forms." PeerJ 3:e1358.

Emerling, C.A. et al. (2015) "Spectral shifts of mammalian ultraviolet-sensitive pigments (short wavelength-sensitive opsin 1) are associated with eye length and photic niche evolution." Proc. Biol. Sci. 282(1819):20151817.

Heger, T. et al. (2015) "Species from different taxonomic groups show similar invasion traits" Immediate Science Ecology 3:1-13.

Hambali, K. et al. (2015) "Behaviour of Captive Ostriches (Struthio camelus) at Universiti Malaysia Kelantan, Bachok Campus, Kelantan, Malaysia." J. Trop. Resour. Sustain. Sci. 3:13-17.

Baladrón, A.V. et al. (2015) "Body Size and Sexual Dimorphism in the Southernmost Subspecies of the Burrowing Owl (Athene cunicularia cunicularia)." Journal of Raptor Research 49(4):479-485.

Blanco, M.B., and Zehr, S.M. (2015) "Striking longevity in a hibernating lemur." Journal of Zoology 296(3):177-188.

Cayuela, H. et al. (2015) "Slow life history and rapid extreme flood: demographic mechanisms and their consequences on population viability in a threatened amphibian." Freshwater Biology 60(11):2349-2361.

Govindaraju, D. et al. (2015) "Genetics, lifestyle and longevity: Lessons from centenarians." Applied & Translational Genomics 4:23-32.

Haddad, W. et al. (2015) "Multiple occurrences of king penguin (Aptenodytes patagonicus) sexual harassment by Antarctic fur seals (Arctocephalus gazella)." Polar Biology 38(5):741-746.

Walton, M.E.M. et al. (2015) "A model for the future: Ecosystem services provided by the aquaculture activities of Veta la Palma, Southern Spain." Aquaculture 448:382-390.

Yu, S. et al. (2015) "Managing biological networks by using text mining and computer-aided curation." Journal of the Korean Physical Society 67(9):1692-1697.

Zeder, M.A. et al. (2015) "A new system for computing long-bone fusion age profiles in Sus scrofa." Journal of Archaeological Science 55:135-150.

Sinsch, U. (2015) "Review: Skeletochronological assessment of demographic life-history traits in amphibians." The Herpetological Journal 25(1):5-13.

Wallach, A.D. et al. (2015) "What is an apex predator?" Oikos 124(11):1453-1461.

Sazykina, T.G. and Kryshev, A.I. (2016) "Simulation of population response to ionizing radiation in an ecosystem with a limiting resource - Model and analytical solutions." J Environ Radioact 151 Pt 1:50-57.

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