GenAge entry for HMGB1 (Homo sapiens)

Gene name (HAGRID: 176)

HGNC symbol
HMGB1 
Aliases
HMG3; SBP-1; DKFZp686A04236; HMG1 
Common name
high mobility group box 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

HMGB1 has been related to DNA unwinding, stress response, and maintenance of genome stability [793]. HMGB1-null mice die shortly after birth [792]. In mice, HMGB1 and other HMG chromosomal proteins have been shown to suffer alterations at various levels during ageing [790], though HMGB1 has not been directly related to human ageing.

Cytogenetic information

Cytogenetic band
13q12
Location
30,457,916 bp to 30,465,965 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001773; myeloid dendritic cell activation
GO:0002218; activation of innate immune response
GO:0002407; dendritic cell chemotaxis
GO:0002437; inflammatory response to antigenic stimulus
GO:0002643; regulation of tolerance induction
GO:0002840; regulation of T cell mediated immune response to tumor cell
GO:0006265; DNA topological change
GO:0006309; apoptotic DNA fragmentation
GO:0006310; DNA recombination
GO:0006357; regulation of transcription from RNA polymerase II promoter
And 38 more GO terms
Cellular component: GO:0000793; condensed chromosome
GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005768; endosome
GO:0005793; endoplasmic reticulum-Golgi intermediate compartment
GO:0005886; plasma membrane
GO:0009986; cell surface
GO:0017053; transcriptional repressor complex
Function: GO:0000400; four-way junction DNA binding
GO:0000405; bubble DNA binding
GO:0001530; lipopolysaccharide binding
GO:0001786; phosphatidylserine binding
GO:0003684; damaged DNA binding
GO:0003690; double-stranded DNA binding
GO:0003697; single-stranded DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005125; cytokine activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
And 10 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, CREBBP, NR3C1, NFKB1, AR, TERF2, RB1, XPA, RELA, HMGB2, TBP, HSPA8, CDK1, PSEN1, TP73
STRING interaction network
Protein-Protein network diagram for HMGB1

Retrieve sequences for HMGB1

ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
Hmgb1
Rattus norvegicus
LOC685520

In other databases

LongevityMap
  • This gene is present as HMGB1
CellAge
  • This gene is present as HMGB1

Selected references

External links

EPD
ORF Accession
NM_002128
CDS Accession
NP_002119
OMIM
163905
HPRD
01228
Ensembl
HMGB1
UniProt/Swiss-Prot
HMGB1_HUMAN
GeneCards
HMGB1
Entrez Gene
3146
UniGene
434102
GenAtlas
HMGB1
Internet
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