GenAge entry for TOP3B (Homo sapiens)

Gene name (HAGRID: 148)

HGNC symbol
TOP3B 
Aliases
 
Common name
topoisomerase (DNA) III beta 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

TOP3B affects the supercoiling of the DNA. Mice lacking TOP3B develop normally but have a shorter lifespan. It is unclear whether these animals age faster [166]. Litter size decreases over time and through successive generations in TOP3B-null mice, probably due to embryonic death [729]. It has been suggested that the age-related phenotype, including lesions in multiple organs as a result of inflammatory responses is due to the development of autoimmunity with age [3659]. A role for TOP3B in human ageing remains to be determined.

Cytogenetic information

Cytogenetic band
22q11.22
Location
21,957,025 bp to 21,982,843 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006265; DNA topological change
GO:0007059; chromosome segregation
Cellular component: GO:0000793; condensed chromosome
GO:0005634; nucleus
Function: GO:0003677; DNA binding
GO:0003916; DNA topoisomerase activity
GO:0003917; DNA topoisomerase type I activity
GO:0005524; ATP binding
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for TOP3B

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
CELE_Y48C3A.14
Drosophila melanogaster
Top3beta
Danio rerio
top3b
Mus musculus
Top3b
Rattus norvegicus
Top3b

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Top3b

Selected references

External links

EPD
ORF Accession
NM_003935
CDS Accession
NP_003926
OMIM
603582
HPRD
04662
Ensembl
TOP3B
UniProt/Swiss-Prot
TOP3B_HUMAN
GeneCards
TOP3B
Entrez Gene
8940
UniGene
436401
GenAtlas
TOP3B
Internet
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