GenAge entry for FLT1 (Homo sapiens)

Gene name (HAGRID: 171)

HGNC symbol
FLT1 
Aliases
VEGFR1; FLT 
Common name
fms-related tyrosine kinase 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

Also known as VEGFR1, FLT1 is a receptor for VEGFA involved in its signalling cascade [975]. Mice without FLT1 die at embryonic stages [782]. In mouse skeletal muscle FLT1 expression levels have been reported to decline with age [1624]. FLT1 has not been directly related to human ageing.

Cytogenetic information

Cytogenetic band
13q12
Location
28,300,346 bp to 28,495,128 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001525; angiogenesis
GO:0002548; monocyte chemotaxis
GO:0007169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284; positive regulation of cell proliferation
GO:0010863; positive regulation of phospholipase C activity
GO:0014068; positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016477; cell migration
GO:0018108; peptidyl-tyrosine phosphorylation
GO:0030154; cell differentiation
GO:0030335; positive regulation of cell migration
GO:0030949; positive regulation of vascular endothelial growth factor receptor signaling pathway
And 12 more GO terms
Cellular component: GO:0005615; extracellular space
GO:0005768; endosome
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0005925; focal adhesion
GO:0043235; receptor complex
Function: GO:0004714; transmembrane receptor protein tyrosine kinase activity
GO:0005021; vascular endothelial growth factor-activated receptor activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0019838; growth factor binding
GO:0036326; VEGF-A-activated receptor activity
GO:0036327; VEGF-B-activated receptor activity
GO:0036332; placental growth factor-activated receptor activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, PTPN11, VEGFA, PIK3R1
STRING interaction network
Protein-Protein network diagram for FLT1

Retrieve sequences for FLT1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
flt1
Drosophila melanogaster
Pvr
Mus musculus
Flt1
Rattus norvegicus
Flt1

Selected references

External links

EPD
ORF Accession
NM_002019
CDS Accession
NP_002010
OMIM
165070
HPRD
01297
Ensembl
FLT1
UniProt/Swiss-Prot
VGFR1_HUMAN
GeneCards
FLT1
Entrez Gene
2321
UniGene
654360
GenAtlas
FLT1
Internet
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