GenAge entry for IL6 (Homo sapiens)

Gene name (HAGRID: 144)

HGNC symbol
IL6 
Aliases
IL-6; BSF2; HGF; HSF; IFNB2 
Common name
interleukin 6 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

IL6 is involved in a variety of processes such as development, differentiation, and inflammation [720]. Mice without IL6 have a defective hepatocyte regeneration and develop liver failure [721]. Transgenic mice expressing high levels of IL6 have a reduced growth rate and low levels of IGF1 [722]. Its levels appear to increase with age, possibly associating IL6 with age-related changes, such as chronic inflammatory diseases [717]. Polymorphisms in the human IL6 gene have been linked to age-related diseases, such as cardiovascular diseases [1050], though they have not been associated with longevity [221]. A role for IL6 in human ageing is plausible though largely obscure.

Cytogenetic information

Cytogenetic band
7p21
Location
22,727,147 bp to 22,732,002 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001781; neutrophil apoptotic process
GO:0001878; response to yeast
GO:0002384; hepatic immune response
GO:0002446; neutrophil mediated immunity
GO:0002548; monocyte chemotaxis
GO:0002675; positive regulation of acute inflammatory response
GO:0002690; positive regulation of leukocyte chemotaxis
GO:0006469; negative regulation of protein kinase activity
GO:0006953; acute-phase response
GO:0006954; inflammatory response
GO:0006959; humoral immune response
And 94 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005737; cytoplasm
GO:0005896; interleukin-6 receptor complex
GO:0009897; external side of plasma membrane
Function: GO:0005125; cytokine activity
GO:0005138; interleukin-6 receptor binding
GO:0005515; protein binding
GO:0008083; growth factor activity
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for IL6

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
Il6
Rattus norvegicus
Il6

In other databases

LongevityMap
  • This gene is present as IL6

Selected references

External links

EPD
HS_IL6_2
ORF Accession
NM_000600
CDS Accession
NP_000591
OMIM
147620
HPRD
00970
Ensembl
IL6
UniProt/Swiss-Prot
IL6_HUMAN
GeneCards
IL6
Entrez Gene
3569
UniGene
654458
GenAtlas
IL6
Internet
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