GenAge entry for BUB3 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 240)

HGNC symbol
BUB3 
Aliases
BUB3L 
Common name
BUB3 mitotic checkpoint protein 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

BUB3 is a mitotic spindle checkpoint gene encoding different isoforms. Haploinsufficiency of both BUB3 and RAE1 in mice, but not haploinsufficiency of either gene by itself, reduces lifespan and appears to accelerate ageing [1594]. BUB3-null mice are embryonic lethal [1595].

Cytogenetic information

Cytogenetic band
10q26
Location
123,154,244 bp to 123,165,370 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000070; mitotic sister chromatid segregation
GO:0007062; sister chromatid cohesion
GO:0007094; mitotic spindle assembly checkpoint
GO:0008608; attachment of spindle microtubules to kinetochore
GO:0031145; anaphase-promoting complex-dependent catabolic process
GO:0042787; protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051301; cell division
GO:0051321; meiotic cell cycle
GO:0051436; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
And 2 more GO terms
Cellular component: GO:0000776; kinetochore
GO:0000777; condensed chromosome kinetochore
GO:0005654; nucleoplasm
GO:0005829; cytosol
GO:0033597; mitotic checkpoint complex
GO:1990298; bub1-bub3 complex
Function: GO:0005515; protein binding
GO:0043130; ubiquitin binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
EGFR, PARP1, RPA1, TOP1, HDAC1, APEX1, BUB1B, HDAC2
STRING interaction network
Protein-Protein network diagram for BUB3

Retrieve sequences for BUB3

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
bub-3
Danio rerio
bub3
Drosophila melanogaster
Bub3
Mus musculus
Bub3
Schizosaccharomyces pombe
bub3

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Bub3
  • A homolog of this gene for Caenorhabditis elegans is present as bub-3

Selected references

External links

EPD
HS_BUB3
ORF Accession
NM_004725
CDS Accession
NP_004716
OMIM
603719
HPRD
04761
Ensembl
BUB3
UniProt/Swiss-Prot
BUB3_HUMAN
GeneCards
BUB3
Entrez Gene
9184
UniGene
418533
GenAtlas
BUB3
Internet
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