GenAge entry for CTGF (Homo sapiens)

Gene name (HAGRID: 206)

HGNC symbol
CTGF 
Aliases
IGFBP8; CCN2 
Common name
connective tissue growth factor 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

CTGF is an important growth factor secreted by vascular endothelial cells. Overexpression of CTGF in mice resulted in dwarfism and decreased bone density [884]. Age-related upregulation of CTGF in senescent cells and in rat liver has also been reported [1737]. Further studies are necessary to determined whether CTGF influences human ageing.

Cytogenetic information

Cytogenetic band
6q23.1
Location
131,948,177 bp to 131,951,378 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001502; cartilage condensation
GO:0001503; ossification
GO:0001525; angiogenesis
GO:0001558; regulation of cell growth
GO:0001894; tissue homeostasis
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0007155; cell adhesion
GO:0007160; cell-matrix adhesion
GO:0007229; integrin-mediated signaling pathway
GO:0007267; cell-cell signaling
GO:0007568; aging
And 34 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005578; proteinaceous extracellular matrix
GO:0005615; extracellular space
GO:0005794; Golgi apparatus
GO:0005801; cis-Golgi network
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005938; cell cortex
GO:0043231; intracellular membrane-bounded organelle
GO:0048471; perinuclear region of cytoplasm
Function: GO:0001968; fibronectin binding
GO:0005178; integrin binding
GO:0005515; protein binding
GO:0005520; insulin-like growth factor binding
GO:0008022; protein C-terminus binding
GO:0008083; growth factor activity
GO:0008201; heparin binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
EGFR, VEGFA
STRING interaction network
Protein-Protein network diagram for CTGF

Retrieve sequences for CTGF

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
ctgfa
Mus musculus
Ctgf
Rattus norvegicus
Ctgf

In other databases

GenDR gene expression
  • A homolog of this gene for Mus musculus is present as Ctgf

Selected references

External links

EPD
HS_CTGF
ORF Accession
NM_001901
CDS Accession
NP_001892
OMIM
121009
HPRD
00412
Ensembl
CTGF
UniProt/Swiss-Prot
CTGF_HUMAN
GeneCards
CTGF
Entrez Gene
1490
UniGene
591346
GenAtlas
CTGF
Internet
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