GenAge entry for PRKCD (Homo sapiens)

Gene name (HAGRID: 54)

HGNC symbol
PRKCD 
Aliases
 
Common name
protein kinase C, delta 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

Involved in the regulation of growth, apoptosis, and differentiation of a variety of cell types [388], PRKCD may influence age-related changes at the CNS and immune system level [387].

Cytogenetic information

Cytogenetic band
3p21.31
Location
53,161,207 bp to 53,192,717 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001666; response to hypoxia
GO:0006468; protein phosphorylation
GO:0006915; apoptotic process
GO:0006921; cellular component disassembly involved in execution phase of apoptosis
GO:0007049; cell cycle
GO:0007165; signal transduction
GO:0007173; epidermal growth factor receptor signaling pathway
GO:0007202; activation of phospholipase C activity
GO:0007596; blood coagulation
GO:0008543; fibroblast growth factor receptor signaling pathway
GO:0009408; response to heat
And 53 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005783; endoplasmic reticulum
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005911; cell-cell junction
GO:0016363; nuclear matrix
GO:0048471; perinuclear region of cytoplasm
Function: GO:0004674; protein serine/threonine kinase activity
GO:0004697; protein kinase C activity
GO:0004699; calcium-independent protein kinase C activity
GO:0004715; non-membrane spanning protein tyrosine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0008047; enzyme activator activity
GO:0019899; enzyme binding
GO:0019901; protein kinase binding
GO:0043560; insulin receptor substrate binding
And 3 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, INSR, PDPK1, PRKDC, PTK2B, LMNB1, PIK3R1
STRING interaction network
Protein-Protein network diagram for PRKCD

Retrieve sequences for PRKCD

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
BX005175.1
Mus musculus
Prkcd
Rattus norvegicus
Prkcd
Schizosaccharomyces pombe
pck1

In other databases

CellAge
  • This gene is present as PRKCD

Selected references

External links

EPD
ORF Accession
NM_006254
CDS Accession
NP_006245
OMIM
176977
HPRD
01501
Ensembl
PRKCD
UniProt/Swiss-Prot
KPCD_HUMAN
GeneCards
PRKCD
Entrez Gene
5580
UniGene
155342
GenAtlas
PRKCD
Internet
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