GenAge entry for NCOR1 (Homo sapiens)

Gene name (HAGRID: 43)

HGNC symbol
NCOR1 
Aliases
N-CoR; hCIT529I10; TRAC1; hN-CoR; KIAA1047; MGC104216; PPP1R109 
Common name
nuclear receptor corepressor 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

NCOR1 is a transcriptional mediator that regulates chromatin condensation. Its exact functions are unknown but there is evidence linking NCOR1 to development [353]. Although there is little evidence to suggest NCOR1 influences ageing, due to its relation with several proteins thought to be related to ageing and age-related diseases [691]. Additionally, NCOR1 knockout mice, although more obese than wild type, display a significant increase in glucose tolerance, enhanced insulin sensitivity and decreased adipose tissue inflammation [3658]. NCOR1 might potentially play some role in human ageing.

Cytogenetic information

Cytogenetic band
17p11.2
Location
16,030,094 bp to 16,215,560 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0002361; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0006351; transcription, DNA-templated
GO:0006366; transcription from RNA polymerase II promoter
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0007179; transforming growth factor beta receptor signaling pathway
GO:0007219; Notch signaling pathway
GO:0010467; gene expression
GO:0014067; negative regulation of phosphatidylinositol 3-kinase cascade
GO:0016568; chromatin modification
GO:0021794; thalamus development
And 13 more GO terms
Cellular component: GO:0000118; histone deacetylase complex
GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005737; cytoplasm
GO:0005876; spindle microtubule
GO:0016580; Sin3 complex
GO:0017053; transcriptional repressor complex
Function: GO:0001102; RNA polymerase II activating transcription factor binding
GO:0003682; chromatin binding
GO:0003700; sequence-specific DNA binding transcription factor activity
GO:0003714; transcription corepressor activity
GO:0005515; protein binding
GO:0035033; histone deacetylase regulator activity
GO:0042826; histone deacetylase binding
GO:0043565; sequence-specific DNA binding
GO:0044212; transcription regulatory region DNA binding
GO:0046965; retinoid X receptor binding
GO:0046966; thyroid hormone receptor binding
And 1 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
HDAC3, AKT1, PPARA, NR3C1, HTT, HDAC1, HESX1, SIN3A, ESR1
STRING interaction network
Protein-Protein network diagram for NCOR1

Retrieve sequences for NCOR1

ORF
ORF
CDS
CDS

Homologs in model organisms

Drosophila melanogaster
Smr
Danio rerio
ncor1
Mus musculus
Ncor1

Selected references

External links

EPD
ORF Accession
NM_006311
CDS Accession
NP_006302
OMIM
600849
HPRD
02911
Ensembl
NCOR1
UniProt/Swiss-Prot
NCOR1_HUMAN
GeneCards
NCOR1
Entrez Gene
9611
UniGene
462323
GenAtlas
NCOR1
Internet
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