GenAge entry for GHRH (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 2)

HGNC symbol
GHRH 
Aliases
GHRF 
Common name
growth hormone releasing hormone 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

GHRH is secreted in the hypothalamus to stimulate the synthesis and secretion of growth hormone (GH1). Defects in the human GHRH gene cause dwarfism while hypersecretion causes gigantism, but it is unknown whether the ageing process is affected in these patients. Declines in GH1 with age may be due to a deficiency in GHRH [1354]. Knockout mice live 46% longer than controls: Females live 43% longer and males 51% longer, though maximum lifespan was only increased (by 33%) in females. Both males and females and markedly smaller than controls [3280]. Given these results, it is possible that GHRH is involved in some aspects of human ageing.

Cytogenetic information

Cytogenetic band
20q11.2
Location
37,251,086 bp to 37,256,896 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0007189; adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007267; cell-cell signaling
GO:0008284; positive regulation of cell proliferation
GO:0019933; cAMP-mediated signaling
GO:0021984; adenohypophysis development
GO:0030252; growth hormone secretion
GO:0030819; positive regulation of cAMP biosynthetic process
GO:0032094; response to food
GO:0040018; positive regulation of multicellular organism growth
GO:0043568; positive regulation of insulin-like growth factor receptor signaling pathway
GO:0046005; positive regulation of circadian sleep/wake cycle, REM sleep
And 2 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0043195; terminal bouton
Function: GO:0016608; growth hormone-releasing hormone activity
GO:0031770; growth hormone-releasing hormone receptor binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
GHR, SST, GHRHR
STRING interaction network
Protein-Protein network diagram for GHRH

Retrieve sequences for GHRH

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
ghrh
Mus musculus
Ghrh
Rattus norvegicus
Ghrh

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Ghrh

Selected references

External links

EPD
HS_GHRH
ORF Accession
NM_021081
CDS Accession
NP_066567
OMIM
139190
HPRD
11752
Ensembl
GHRH
UniProt/Swiss-Prot
SLIB_HUMAN
GeneCards
GHRH
Entrez Gene
2691
UniGene
37023
GenAtlas
GHRH
Internet
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