GenAge entry for IRS2 (Homo sapiens)

Gene name (HAGRID: 34)

HGNC symbol
IRS2 
Aliases
 
Common name
insulin receptor substrate 2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

IRS2 and IRS1 mediate many of the cellular actions of insulin (INS). Results from model organisms suggest IRS2 is involved in the IGF1/GH1 axis that appears to influence ageing in model organisms. In Drosophila, loss of chico, an insulin receptor substrate, extends lifespan [188]. IRS2 brain-specific knockout mice were overweight, hyperinsulinemic, glucose intolerant, yet more active and lived up to 18% longer [1919]. In another experiment, however, IRS2 knockout mice were reported to have a shorter median lifespan. Heterozygous animals had normal lifespans [1924]. IRS2 may also be involved in the extended lifespan of other mouse strains [292]. In humans, mutations in IRS2 have been associated with diabetes [1659]. IRS2 likely plays a role in some human age-related pathologies, but its exact impact on the human ageing process is unknown.

Cytogenetic information

Cytogenetic band
13q34
Location
109,753,837 bp to 109,786,567 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0002053; positive regulation of mesenchymal cell proliferation
GO:0002903; negative regulation of B cell apoptotic process
GO:0006006; glucose metabolic process
GO:0007165; signal transduction
GO:0007173; epidermal growth factor receptor signaling pathway
GO:0007420; brain development
GO:0008283; cell proliferation
GO:0008284; positive regulation of cell proliferation
GO:0008286; insulin receptor signaling pathway
GO:0008543; fibroblast growth factor receptor signaling pathway
GO:0009749; response to glucose
And 19 more GO terms
Cellular component: GO:0005829; cytosol
GO:0005886; plasma membrane
Function: GO:0004871; signal transducer activity
GO:0005158; insulin receptor binding
GO:0005515; protein binding
GO:0005543; phospholipid binding
GO:0019901; protein kinase binding
GO:0043548; phosphatidylinositol 3-kinase binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, IGF1R, PTPN11, INS, INSR, EPOR, GRB2, YWHAZ, PIK3R1, PIK3CA
STRING interaction network
Protein-Protein network diagram for IRS2

Retrieve sequences for IRS2

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
zgc:56306
Mus musculus
Irs2
Rattus norvegicus
Irs2

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Irs2
GenDR gene expression
  • A homolog of this gene for Mus musculus is present as Irs2
LongevityMap
  • This gene is present as IRS2

Selected references

External links

EPD
ORF Accession
NM_003749
CDS Accession
NP_003740
OMIM
600797
HPRD
02878
Ensembl
IRS2
UniProt/Swiss-Prot
IRS2_HUMAN
GeneCards
IRS2
Entrez Gene
8660
UniGene
442344
GenAtlas
IRS2
Internet
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