GenAge entry for KCNA3 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 268)

HGNC symbol
KCNA3 
Aliases
Kv1.3; MK3; HLK3; HPCN3 
Common name
potassium channel, voltage gated shaker related subfamily A, member 3 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

The potassium voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or Kv1.3, is involved in the repolarization of nerve cells following an action potential. It also plays an essential role in T-cell proliferation and activation.

Null mice weigh less than controls, have modified ingestive behaviours, are resistant to fat deposition following a moderately high-fat dietary regime and have improved longevity and fecundity. Moreover, gene-targeted deletion in the short-lived MC4R-null mice returned the lifespan of these mice to approximately wild-type levels [2163].

A variant in the promoter of the KCNA3 gene was found associated with impaired glucose tolerance and lower insulin sensitivity [2164]. KCNA3 is also involved in age-related diseases, like Alzheimer's disease and cancer. For example, an aberrant glutamate-dependent modulation of KCNA3 channels was found in T lymphocytes of Alzheimer patients [2165], and it was shown that the inhibition of KCNA3 has an anti-proliferative effect, blocking proliferation of human lung adenocarcinoma cells [2166]. A reduced expression of KCNA3 was also found in human prostate cancer [2168]. So far there has been no direct evidence linking KCNA3 to human longevity and further research is needed.

Cytogenetic information

Cytogenetic band
1p13.3
Location
110,672,452 bp to 110,675,033 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006813; potassium ion transport
GO:0007268; synaptic transmission
GO:0051260; protein homooligomerization
Cellular component: GO:0005886; plasma membrane
GO:0008076; voltage-gated potassium channel complex
GO:0045121; membrane raft
Function: GO:0005244; voltage-gated ion channel activity
GO:0005251; delayed rectifier potassium channel activity
GO:0015271; outward rectifier potassium channel activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
BAX
STRING interaction network
Protein-Protein network diagram for KCNA3

Retrieve sequences for KCNA3

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
LOC100330283
Mus musculus
Kcna3
Rattus norvegicus
Kcna3

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Kcna3

Selected references

External links

EPD
ORF Accession
NM_002232
CDS Accession
NP_002223
OMIM
176263
HPRD
15937
Ensembl
KCNA3
UniProt/Swiss-Prot
KCNA3_HUMAN
GeneCards
KCNA3
Entrez Gene
3738
UniGene
169948
GenAtlas
KCNA3
Internet
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