GenAge entry for INSR (Homo sapiens)

Gene name (HAGRID: 42)

HGNC symbol
INSR 
Aliases
CD220 
Common name
insulin receptor 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

INSR binds insulin (INS) and regulates energy metabolism [1108]. Evidence from model organisms, including results from fruit flies [187] and roundworms [539], relates INSR homologues to ageing, most likely as part of the GH1/IGF1 axis. In mice, disruption of INSR in adipose tissue extends longevity but does not appear to delay ageing [178]. In flies, the two most common alleles (InRlong and InRshort) are associated with predictable differences in levels of insulin signaling, fecundity, development time, body size, and stress tolerance (temperature and starvation) [3657]. Flies carrying the InRshort and InRlong alleles generally showed little difference in rates of aging, with InRshort males displaying a reduced mortality late in life. Heterozygotes in both sexes live significantly longer than homozygote genotypes [3657]. Mutations in the human INSR gene have been associated with insulin resistance [1661]. INSR could play a role in some human age-related pathologies, but it is not known whether it is a major player in human ageing.

Cytogenetic information

Cytogenetic band
19p13
Location
7,112,255 bp to 7,294,000 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000187; activation of MAPK activity
GO:0001934; positive regulation of protein phosphorylation
GO:0003007; heart morphogenesis
GO:0005975; carbohydrate metabolic process
GO:0006355; regulation of transcription, DNA-dependent
GO:0007186; G-protein coupled receptor signaling pathway
GO:0008284; positive regulation of cell proliferation
GO:0008286; insulin receptor signaling pathway
GO:0018108; peptidyl-tyrosine phosphorylation
GO:0019087; transformation of host cell by virus
GO:0023014; signal transduction by phosphorylation
And 22 more GO terms
Cellular component: GO:0005886; plasma membrane
GO:0005887; integral to plasma membrane
GO:0005899; insulin receptor complex
GO:0005901; caveola
GO:0010008; endosome membrane
GO:0016020; membrane
Function: GO:0004713; protein tyrosine kinase activity
GO:0004716; receptor signaling protein tyrosine kinase activity
GO:0005009; insulin-activated receptor activity
GO:0005159; insulin-like growth factor receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0005525; GTP binding
GO:0031994; insulin-like growth factor I binding
GO:0031995; insulin-like growth factor II binding
GO:0042169; SH2 domain binding
GO:0043548; phosphatidylinositol 3-kinase binding
And 4 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, PTPN11, IGF2, INS, IRS1, PTPN1, IRS2, HRAS, PRKCD, PRKCA, MAPK3
STRING interaction network
Protein-Protein network diagram for INSR

Retrieve sequences for INSR

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
insrb
Mus musculus
Insr
Rattus norvegicus
Insr

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Insr
LongevityMap
  • This gene is present as INSR

Selected references

External links

EPD
ORF Accession
NM_000208
CDS Accession
NP_000199
OMIM
147670
HPRD
00975
Ensembl
INSR
UniProt/Swiss-Prot
INSR_HUMAN
GeneCards
INSR
Entrez Gene
3643
UniGene
465744
GenAtlas
INSR
Internet
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