GenAge entry for GSTP1 (Homo sapiens)

Gene name (HAGRID: 157)

HGNC symbol
GSTP1 
Aliases
GSTP; FAEES3; GST3 
Common name
glutathione S-transferase pi 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

GSTP1 is part of the glutathione system involved in oxidative protection [44]. Overexpression of a homologue of GSTP1 in roundworms extended lifespan by about 22% [1548]. There is some evidence linking polymorphisms in the human GSTP1 gene to Parkinson's disease induced by pesticides [750], but GSTP1's role in human ageing remains unknown.

Cytogenetic information

Cytogenetic band
11q13
Location
67,583,595 bp to 67,586,653 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000302; response to reactive oxygen species
GO:0002674; negative regulation of acute inflammatory response
GO:0006469; negative regulation of protein kinase activity
GO:0006749; glutathione metabolic process
GO:0006805; xenobiotic metabolic process
GO:0007417; central nervous system development
GO:0009890; negative regulation of biosynthetic process
GO:0010804; negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0032691; negative regulation of interleukin-1 beta production
GO:0032720; negative regulation of tumor necrosis factor production
GO:0032872; regulation of stress-activated MAPK cascade
And 21 more GO terms
Cellular component: GO:0005622; intracellular
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0097057; TRAF2-GSTP1 complex
Function: GO:0004364; glutathione transferase activity
GO:0005515; protein binding
GO:0008432; JUN kinase binding
GO:0019207; kinase regulator activity
GO:0035730; S-nitrosoglutathione binding
GO:0035731; dinitrosyl-iron complex binding
GO:0070026; nitric oxide binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
MAPK8
STRING interaction network
Protein-Protein network diagram for GSTP1

Retrieve sequences for GSTP1

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
gst-10
Danio rerio
gstp2
Mus musculus
Gstp2
Rattus norvegicus
Gstp1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as gst-10
LongevityMap
  • This gene is present as GSTP1

Selected references

External links

EPD
HS_GSTP1
ORF Accession
NM_000852
CDS Accession
NP_000843
OMIM
134660
HPRD
00614
Ensembl
GSTP1
UniProt/Swiss-Prot
GSTP1_HUMAN
GeneCards
GSTP1
Entrez Gene
2950
UniGene
523836
GenAtlas
GSTP1
Internet
Search Google