GenAge entry for FEN1 (Homo sapiens)

Gene name (HAGRID: 114)

HGNC symbol
FEN1 
Aliases
FEN-1; MF1; RAD2 
Common name
flap structure-specific endonuclease 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

Involved in DNA processing, FEN1 has been associated with cancer progression [586]. A FEN1 role in ageing is unknown, but due to its interactions with WRN [584] and PCNA [588], FEN1 might, in theory, be involved in human ageing.

Cytogenetic information

Cytogenetic band
11q12
Location
61,792,637 bp to 61,797,242 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000278; mitotic cell cycle
GO:0000722; telomere maintenance via recombination
GO:0000723; telomere maintenance
GO:0006260; DNA replication
GO:0006271; DNA strand elongation involved in DNA replication
GO:0006281; DNA repair
GO:0006284; base-excision repair
GO:0006302; double-strand break repair
GO:0007613; memory
GO:0009650; UV protection
GO:0032201; telomere maintenance via semi-conservative replication
And 3 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005739; mitochondrion
Function: GO:0000287; magnesium ion binding
GO:0003677; DNA binding
GO:0003684; damaged DNA binding
GO:0003690; double-stranded DNA binding
GO:0004519; endonuclease activity
GO:0004523; ribonuclease H activity
GO:0004527; exonuclease activity
GO:0005515; protein binding
GO:0008309; double-stranded DNA exodeoxyribonuclease activity
GO:0008409; 5'-3' exonuclease activity
GO:0017108; 5'-flap endonuclease activity
And 2 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
WRN, EP300, PCNA, APEX1
STRING interaction network
Protein-Protein network diagram for FEN1

Retrieve sequences for FEN1

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
crn-1
Drosophila melanogaster
Fen1
Danio rerio
fen1
Mus musculus
Fen1
Rattus norvegicus
Fen1
Saccharomyces cerevisiae
RAD27
Schizosaccharomyces pombe
rad2

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as RAD27
LongevityMap
  • This gene is present as FEN1

Selected references

External links

EPD
HS_FEN1
ORF Accession
NM_004111
CDS Accession
NP_004102
OMIM
600393
HPRD
02670
Ensembl
FEN1
UniProt/Swiss-Prot
FEN1_HUMAN
GeneCards
FEN1
Entrez Gene
2237
UniGene
409065
GenAtlas
FEN1
Internet
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