GenAge entry for POU1F1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 4)

HGNC symbol
POU1F1 
Aliases
GHF-1; POU1F1a; PIT1 
Common name
POU class 1 homeobox 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

The POU1F1 transcription factor is expressed in the pituitary where it regulates pituitary development and hormone expression. It activates growth hormone (GH1) and is involved in mammalian development.

Snell dwarf mouse are a strain mutant for POU1F1 that live significantly longer than controls and show signs of ageing retardation [5]. POU1F1 abnormalities have been reported in humans associated with lower levels of GH1, prolactin, and thyroid-stimulating hormone, but with little or no evidence of an impact on ageing [233].

Cytogenetic information

Cytogenetic band
3p11
Location
87,259,633 bp to 87,276,587 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001708; cell fate specification
GO:0006355; regulation of transcription, DNA-templated
GO:0006366; transcription from RNA polymerase II promoter
GO:0008284; positive regulation of cell proliferation
GO:0008285; negative regulation of cell proliferation
GO:0008340; determination of adult lifespan
GO:0030183; B cell differentiation
GO:0032962; positive regulation of inositol trisphosphate biosynthetic process
GO:0040018; positive regulation of multicellular organism growth
GO:0043567; regulation of insulin-like growth factor receptor signaling pathway
And 5 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005737; cytoplasm
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001085; RNA polymerase II transcription factor binding
GO:0001102; RNA polymerase II activating transcription factor binding
GO:0001105; RNA polymerase II transcription coactivator activity
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003714; transcription corepressor activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
NCOR1, PPARA, CREBBP, NR3C1, JUN, MED1, PPARG
STRING interaction network
Protein-Protein network diagram for POU1F1

Retrieve sequences for POU1F1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
pou1f1
Mus musculus
Pou1f1
Rattus norvegicus
Pou1f1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Pou1f1

Selected references

External links

EPD
ORF Accession
NM_000306
CDS Accession
NP_000297
OMIM
173110
HPRD
01409
Ensembl
POU1F1
UniProt/Swiss-Prot
PIT1_HUMAN
GeneCards
POU1F1
Entrez Gene
5449
GenAtlas
POU1F1
Internet
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