GenAge entry for LEP (Homo sapiens)

Gene name (HAGRID: 217)

HGNC symbol
LEP 
Aliases
OBS; OB 
Common name
leptin 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

LEP is secreted from adipose tissues and is involved in food intake and energy expenditure. Mice with mutations in the LEP gene are obese [1212]. Female mice injected with LEP grew slower but had an early onset of reproductive function [1565]. LEP deficiency in humans is associated with early-onset obesity [1741]. Due to its impact on energy metabolism and reproduction, LEP could be related to neuroendocrine systems involved in ageing as well as play a part in age-related diseases such as diabetes and atherosclerosis.

Cytogenetic information

Cytogenetic band
7q31.3
Location
128,241,278 bp to 128,257,629 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001542; ovulation from ovarian follicle
GO:0001666; response to hypoxia
GO:0001819; positive regulation of cytokine production
GO:0001890; placenta development
GO:0002021; response to dietary excess
GO:0006006; glucose metabolic process
GO:0006111; regulation of gluconeogenesis
GO:0006112; energy reserve metabolic process
GO:0006114; glycerol biosynthetic process
GO:0007260; tyrosine phosphorylation of STAT protein
And 41 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005737; cytoplasm
Function: GO:0005179; hormone activity
GO:0008083; growth factor activity
GO:0051428; peptide hormone receptor binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
INS, LEPR, CLU
STRING interaction network
Protein-Protein network diagram for LEP

Retrieve sequences for LEP

ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
Lep
Rattus norvegicus
Lep

In other databases

LongevityMap
  • This gene is present as LEP

Selected references

External links

EPD
ORF Accession
NM_000230
CDS Accession
NP_000221
OMIM
164160
HPRD
01249
Ensembl
LEP
UniProt/Swiss-Prot
LEP_HUMAN
GeneCards
LEP
Entrez Gene
3952
UniGene
194236
GenAtlas
LEP
Internet
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