GenAge entry for FGF21 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 293)

HGNC symbol
FGF21 
Aliases
 
Common name
fibroblast growth factor 21 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

FGF21 is a pro-longevity hormone released by the liver that regulates glucose uptake in adipocytes. Transgenic overexpression of Fgf21 in hepatocytes increases average and maximum lifespan by 36% and 16%, respectively [3252]. Studies suggest that methionine restriction can reverse the negative effects of aging on body mass, adiposity, and insulin resistance through an FGF21 mechanism [3602]. Given these results and its role in metabolism, FGF21 may play a role in metabolic aspects of ageing. Additionally, FGF21 expression in the thymus declines with age. FGF21 overexpression in mice protects against thymic involution, increases perithymic brown adipose tissue and elevates thymic T-cell export. Loss of FGF21 in middle aged mice accelerates thymic aging. Thus, FGF21 may integrate the metabolic and immune systems [4359]. In humans, FGF21 has been associated with Type 2 diabetes.

Cytogenetic information

Cytogenetic band
19q13.33
Location
48,756,087 bp to 48,758,325 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0007165; signal transduction
GO:0007267; cell-cell signaling
GO:0008284; positive regulation of cell proliferation
GO:0010898; positive regulation of triglyceride catabolic process
GO:0010988; regulation of low-density lipoprotein particle clearance
GO:0014823; response to activity
GO:0030968; endoplasmic reticulum unfolded protein response
GO:0031667; response to nutrient levels
GO:0035690; cellular response to drug
GO:0045716; positive regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0046326; positive regulation of glucose import
And 10 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005623; cell
Function: GO:0005104; fibroblast growth factor receptor binding
GO:0005515; protein binding
GO:0008083; growth factor activity
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for FGF21

ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
Fgf21
Rattus norvegicus
Fgf21

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Fgf21

Selected references

External links

EPD
ORF Accession
NM_019113
CDS Accession
NP_061986
OMIM
609436
HPRD
09447
Ensembl
FGF21
UniProt/Swiss-Prot
FGF21_HUMAN
GeneCards
FGF21
Entrez Gene
26291
UniGene
283015
GenAtlas
FGF21
Internet
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