GenAge entry for BUB1B (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 197)

HGNC symbol
BUB1B 
Aliases
BUBR1; MAD3L; Bub1A; SSK1 
Common name
BUB1 mitotic checkpoint serine/threonine kinase B 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

BUB1B is a mitotic checkpoint that controls chromosome segregation and maintains genetic stability [1080]. BUB1B-null mice die at embryonic stages [1081], but accelerated ageing has been reported in mice with BUB1B insufficiency [1082]. Overexpression of BubR1, in mice, preserves genomic integrity, reduces tumorigenesis and extends average and maximum lifespan by 14% and 18%, respectively [3267]. In humans, mutations in the BUB1B gene have been associated with cancer [1733].

Cytogenetic information

Cytogenetic band
15q15
Location
40,161,009 bp to 40,221,136 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006468; protein phosphorylation
GO:0006915; apoptotic process
GO:0007062; sister chromatid cohesion
GO:0007067; mitotic nuclear division
GO:0007091; metaphase/anaphase transition of mitotic cell cycle
GO:0007093; mitotic cell cycle checkpoint
GO:0007094; mitotic spindle assembly checkpoint
GO:0008283; cell proliferation
GO:0031145; anaphase-promoting complex-dependent catabolic process
GO:0034501; protein localization to kinetochore
GO:0042787; protein ubiquitination involved in ubiquitin-dependent protein catabolic process
And 5 more GO terms
Cellular component: GO:0000776; kinetochore
GO:0000777; condensed chromosome kinetochore
GO:0000778; condensed nuclear chromosome kinetochore
GO:0000940; condensed chromosome outer kinetochore
GO:0005680; anaphase-promoting complex
GO:0005737; cytoplasm
GO:0005815; microtubule organizing center
GO:0005829; cytosol
GO:0048471; perinuclear region of cytoplasm
GO:0051233; spindle midzone
Function: GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
PARP1, BRCA2, MXI1, EEF2, SNCG, HDAC1, CCNA2, BUB1B, MDM2, SUMO1, BUB3, RAE1, TP73
STRING interaction network
Protein-Protein network diagram for BUB1B

Retrieve sequences for BUB1B

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
si:ch1073-192f24.1
Mus musculus
Bub1b
Rattus norvegicus
Bub1b
Schizosaccharomyces pombe
bub1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Bub1b

Selected references

External links

EPD
ORF Accession
NM_001211
CDS Accession
NP_001202
OMIM
602860
HPRD
04176
Ensembl
BUB1B
UniProt/Swiss-Prot
BUB1B_HUMAN
GeneCards
BUB1B
Entrez Gene
701
UniGene
631699
GenAtlas
BUB1B
Internet
Search Google