GenAge entry for VEGFA (Homo sapiens)

Gene name (HAGRID: 77)

HGNC symbol
VEGFA 
Aliases
VEGF-A; VPF; VEGF 
Common name
vascular endothelial growth factor A 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

VEGFA is a growth factor that been widely implicated in age-related changes [1274], tumorigenesis, and neurogenesis [469]. Mutations in the human VEGFA gene have been associated with type 2 diabetes [1674] and atherosclerosis [1675]. Inactivation of VEGFA in mice results in embryonic lethality [470]. It is unclear whether VEGFA is directly involved in ageing, yet it remains a possible player.

Cytogenetic information

Cytogenetic band
6p12
Location
43,770,209 bp to 43,786,486 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001525; angiogenesis
GO:0001541; ovarian follicle development
GO:0001569; branching involved in blood vessel morphogenesis
GO:0001570; vasculogenesis
GO:0001666; response to hypoxia
GO:0001701; in utero embryonic development
GO:0001822; kidney development
GO:0001934; positive regulation of protein phosphorylation
GO:0001938; positive regulation of endothelial cell proliferation
GO:0002042; cell migration involved in sprouting angiogenesis
And 80 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005578; proteinaceous extracellular matrix
GO:0005615; extracellular space
GO:0005737; cytoplasm
GO:0009986; cell surface
GO:0016020; membrane
GO:0030141; secretory granule
GO:0031093; platelet alpha granule lumen
Function: GO:0001968; fibronectin binding
GO:0005125; cytokine activity
GO:0005161; platelet-derived growth factor receptor binding
GO:0005172; vascular endothelial growth factor receptor binding
GO:0005515; protein binding
GO:0008083; growth factor activity
GO:0008201; heparin binding
GO:0042056; chemoattractant activity
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0043183; vascular endothelial growth factor receptor 1 binding
And 5 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
HSP90AA1, VEGFA, FLT1, CTGF
STRING interaction network
Protein-Protein network diagram for VEGFA

Retrieve sequences for VEGFA

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
vegfab
Mus musculus
Vegfa
Rattus norvegicus
Vegfa

In other databases

LongevityMap
  • This gene is present as VEGFA
CellAge
  • This gene is present as VEGFA

Selected references

External links

EPD
ORF Accession
NM_003376
CDS Accession
NP_003367
OMIM
192240
HPRD
01889
Ensembl
VEGFA
UniProt/Swiss-Prot
VEGFA_HUMAN
GeneCards
VEGFA
Entrez Gene
7422
UniGene
73793
GenAtlas
VEGFA
Internet
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