GenAge entry for UBE2I (Homo sapiens)

Gene name (HAGRID: 85)

HGNC symbol
UBE2I 
Aliases
UBC9 
Common name
ubiquitin-conjugating enzyme E2I 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

UBE2I catalyzes the attachment of SUMO1 to other proteins. Although no direct evidence exists to suggest a role for UBE2I in ageing, it is related to, among others, WRN [903] and PCNA [490], suggesting it might play a role in DNA repair and perhaps even in ageing. UBE2I deficiency in mice results in embryonic lethality [1678].

Cytogenetic information

Cytogenetic band
16p13.3
Location
1,309,627 bp to 1,327,018 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006464; cellular protein modification process
GO:0006511; ubiquitin-dependent protein catabolic process
GO:0007059; chromosome segregation
GO:0007067; mitotic nuclear division
GO:0016032; viral process
GO:0016925; protein sumoylation
GO:0043123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045892; negative regulation of transcription, DNA-templated
GO:0051301; cell division
GO:0070911; global genome nucleotide-excision repair
And 2 more GO terms
Cellular component: GO:0000795; synaptonemal complex
GO:0005634; nucleus
GO:0005635; nuclear envelope
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0016605; PML body
GO:1990234; transferase complex
GO:1990356; sumoylated E2 ligase complex
Function: GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008134; transcription factor binding
GO:0016874; ligase activity
GO:0019789; SUMO transferase activity
GO:0019899; enzyme binding
GO:0031625; ubiquitin protein ligase binding
GO:0043398; HLH domain binding
GO:0044822; poly(A) RNA binding
GO:0061630; ubiquitin protein ligase activity
GO:0061656; SUMO conjugating enzyme activity
And 2 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, LMNA, MYC, EGF, FOS, PPARA, PARP1, BRCA1, PTEN, CREBBP, HIF1A, NCOR1, BLM, BCL2, TOP2A, TOP2B, TOP1, RAD51, UBE2I, EP300, PML, PRKDC, AR, XRCC5, TERF2, RB1, HSF1, FOXM1, UCHL1, APP, RAD52, SIRT1, HDAC1, JUN, FAS, BMI1, TFAP2A, CREB1, ATF2, TBP, APEX1, CDK1, MDM2, TAF1, TCF3, SUMO1, NR3C1, ESR1, NFKBIA, CDKN2A, TP63, HIC1, PPARGC1A, PPARG, TP53BP1, NCOR2, TP73
STRING interaction network
Protein-Protein network diagram for UBE2I

Retrieve sequences for UBE2I

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
ubc-9
Danio rerio
ube2ib
Drosophila melanogaster
lwr
Mus musculus
Ube2i
Rattus norvegicus
Ube2i
Saccharomyces cerevisiae
UBC9
Schizosaccharomyces pombe
hus5

Selected references

External links

EPD
ORF Accession
NM_194259
CDS Accession
NP_919235
OMIM
601661
HPRD
09045
Ensembl
UBE2I
UniProt/Swiss-Prot
UBC9_HUMAN
GeneCards
UBE2I
Entrez Gene
7329
UniGene
302903
GenAtlas
UBE2I
Internet
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