GenAge entry for UBE2I (Homo sapiens)

Gene name (HAGRID: 85)

HGNC symbol
UBE2I 
Aliases
UBC9 
Common name
ubiquitin-conjugating enzyme E2I 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

UBE2I catalyzes the attachment of SUMO1 to other proteins. Although no direct evidence exists to suggest a role for UBE2I in ageing, it is related to, among others, WRN [903] and PCNA [490], suggesting it might play a role in DNA repair and perhaps even in ageing. UBE2I deficiency in mice results in embryonic lethality [1678].

Cytogenetic information

Cytogenetic band
16p13.3
Location
1,309,627 bp to 1,327,018 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006464; cellular protein modification process
GO:0006511; ubiquitin-dependent protein catabolic process
GO:0007059; chromosome segregation
GO:0007067; mitosis
GO:0010469; regulation of receptor activity
GO:0016925; protein sumoylation
GO:0019048; modulation by virus of host morphology or physiology
GO:0033145; positive regulation of intracellular steroid hormone receptor signaling pathway
GO:0043161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045892; negative regulation of transcription, DNA-dependent
And 3 more GO terms
Cellular component: GO:0000795; synaptonemal complex
GO:0001650; fibrillar center
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0016605; PML body
GO:0030425; dendrite
GO:0045202; synapse
Function: GO:0004842; ubiquitin-protein ligase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0008134; transcription factor binding
GO:0019789; SUMO ligase activity
GO:0019899; enzyme binding
GO:0043398; HLH domain binding
GO:0043425; bHLH transcription factor binding
GO:0071535; RING-like zinc finger domain binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, WRN, PTEN, TOP1, RAD51, EP300, PCNA, ATF2, APEX1, SUMO1
STRING interaction network
Protein-Protein network diagram for UBE2I

Retrieve sequences for UBE2I

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
ubc-9
Drosophila melanogaster
lwr
Danio rerio
ube2ib
Mus musculus
Ube2i
Rattus norvegicus
Ube2i
Saccharomyces cerevisiae
UBC9
Schizosaccharomyces pombe
hus5

Selected references

External links

EPD
ORF Accession
NM_194259
CDS Accession
NP_919235
OMIM
601661
HPRD
09045
Ensembl
UBE2I
UniProt/Swiss-Prot
UBC9_HUMAN
GeneCards
UBE2I
Entrez Gene
7329
UniGene
302903
GenAtlas
UBE2I
Internet
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