GenAge entry for A2M (Homo sapiens)

Gene name (HAGRID: 139)

HGNC symbol
A2M 
Aliases
FWP007; S863-7; CPAMD5 
Common name
alpha-2-macroglobulin 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

A2M inhibits proteinases. Knockout mice are more resistant to endotoxins [702], though they have not been shown to live longer. In humans, A2M has been associated with neurodegenerative diseases [703], but a direct association with human ageing has not been established.

Cytogenetic information

Cytogenetic band
12p13.31
Location
9,067,708 bp to 9,115,962 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001869; negative regulation of complement activation, lectin pathway
GO:0002576; platelet degranulation
GO:0007264; small GTPase mediated signal transduction
GO:0007596; blood coagulation
GO:0007597; blood coagulation, intrinsic pathway
GO:0030168; platelet activation
GO:0048863; stem cell differentiation
GO:0051056; regulation of small GTPase mediated signal transduction
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005829; cytosol
GO:0031093; platelet alpha granule lumen
GO:0070062; extracellular vesicular exosome
Function: GO:0004867; serine-type endopeptidase inhibitor activity
GO:0005515; protein binding
GO:0019838; growth factor binding
GO:0019899; enzyme binding
GO:0019959; interleukin-8 binding
GO:0019966; interleukin-1 binding
GO:0043120; tumor necrosis factor binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
NGF, TGFB1, APOE
STRING interaction network
Protein-Protein network diagram for A2M

Retrieve sequences for A2M

ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
A2mp
Rattus norvegicus
LOC100911545

Selected references

External links

EPD
ORF Accession
NM_000014
CDS Accession
NP_000005
OMIM
103950
HPRD
00072
Ensembl
A2M
UniProt/Swiss-Prot
A2MG_HUMAN
GeneCards
A2M
Entrez Gene
2
UniGene
212838
GenAtlas
A2M
Internet
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