Human Ageing-Associated Genes

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HAGRID	HGNC symbol	Common name	Display entry
1	GHR	growth hormone receptor	GHR
2	GHRH	growth hormone releasing hormone	GHRH
3	SHC1	SHC (Src homology 2 domain containing) transforming protein 1	SHC1
4	POU1F1	POU class 1 homeobox 1	POU1F1
5	PROP1	PROP paired-like homeobox 1	PROP1
6	TP53	tumor protein p53	TP53
7	TERC	telomerase RNA component	TERC
8	TERT	telomerase reverse transcriptase	TERT
9	ATM	ATM serine/threonine kinase	ATM
10	PLAU	plasminogen activator, urokinase	PLAU
11	ERCC2	excision repair cross-complementation group 2	ERCC2
12	ERCC8	excision repair cross-complementation group 8	ERCC8
13	WRN	Werner syndrome, RecQ helicase-like	WRN
14	LMNA	lamin A/C	LMNA
15	IGF1R	insulin-like growth factor 1 receptor	IGF1R
16	TXN	thioredoxin	TXN
17	KL	klotho	KL
18	E2F1	E2F transcription factor 1	E2F1
19	PTPN11	protein tyrosine phosphatase, non-receptor type 11	PTPN11
20	NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	NFKB2
21	STAT5B	signal transducer and activator of transcription 5B	STAT5B
22	STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	STAT3
23	STAT5A	signal transducer and activator of transcription 5A	STAT5A
24	NRG1	neuregulin 1	NRG1
25	HDAC3	histone deacetylase 3	HDAC3
26	GH1	growth hormone 1	GH1
27	IL7R	interleukin 7 receptor	IL7R
28	IGF1	insulin-like growth factor 1 (somatomedin C)	IGF1
29	IGF2	insulin-like growth factor 2	IGF2
30	INS	insulin	INS
31	NGF	nerve growth factor (beta polypeptide)	NGF
32	IRS1	insulin receptor substrate 1	IRS1
33	PTPN1	protein tyrosine phosphatase, non-receptor type 1	PTPN1
34	IRS2	insulin receptor substrate 2	IRS2
35	AKT1	v-akt murine thymoma viral oncogene homolog 1	AKT1
36	PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	PIK3CB
37	NGFR	nerve growth factor receptor	NGFR
38	HRAS	Harvey rat sarcoma viral oncogene homolog	HRAS
39	MYC	v-myc avian myelocytomatosis viral oncogene homolog	MYC
40	EGFR	epidermal growth factor receptor	EGFR
41	ERBB2	erb-b2 receptor tyrosine kinase 2	ERBB2
42	INSR	insulin receptor	INSR
43	NCOR1	nuclear receptor corepressor 1	NCOR1
44	NBN	nibrin	NBN
45	JUND	jun D proto-oncogene	JUND
46	IL2	interleukin 2	IL2
47	PDGFB	platelet-derived growth factor beta polypeptide	PDGFB
48	EGF	epidermal growth factor	EGF
49	IL2RG	interleukin 2 receptor, gamma	IL2RG
50	FOS	FBJ murine osteosarcoma viral oncogene homolog	FOS
51	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	PDGFRB
52	EPOR	Erythropoietin receptor	EPOR
53	SST	somatostatin	SST
54	PRKCD	protein kinase C, delta	PRKCD
55	PPARA	peroxisome proliferator-activated receptor alpha	PPARA
56	RET	ret proto-oncogene	RET
57	PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	PLCG2
58	PEX5	peroxisomal biogenesis factor 5	PEX5
59	TCF3	transcription factor 3	TCF3
60	PARP1	poly (ADP-ribose) polymerase 1	PARP1
61	BRCA1	breast cancer 1, early onset	BRCA1
62	PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	PIN1
63	PTEN	phosphatase and tensin homolog	PTEN
64	CREBBP	CREB binding protein	CREBBP
65	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	HIF1A
66	UBB	ubiquitin B	UBB
67	RPA1	replication protein A1, 70kDa	RPA1
68	BLM	Bloom syndrome, RecQ helicase-like	BLM
69	BCL2	B-cell CLL/lymphoma 2	BCL2
70	S100B	S100 calcium binding protein B	S100B
71	VCP	valosin containing protein	VCP
72	POLG	polymerase (DNA directed), gamma	POLG
73	IGFBP3	insulin-like growth factor binding protein 3	IGFBP3
74	HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	HSP90AA1
75	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	NR3C1
76	EGR1	early growth response 1	EGR1
77	VEGFA	vascular endothelial growth factor A	VEGFA
78	ABL1	ABL proto-oncogene 1, non-receptor tyrosine kinase	ABL1
79	BRCA2	breast cancer 2, early onset	BRCA2
80	TOP2A	topoisomerase (DNA) II alpha	TOP2A
81	TOP2B	topoisomerase (DNA) II beta	TOP2B
82	NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	NFKB1
83	TOP1	topoisomerase (DNA) I	TOP1
84	RAD51	RAD51 recombinase	RAD51
85	UBE2I	ubiquitin-conjugating enzyme E2I	UBE2I
86	TNF	tumor necrosis factor	TNF
87	PDPK1	3-phosphoinositide dependent protein kinase 1	PDPK1
88	CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	CEBPA
89	CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	CEBPB
90	MXI1	MAX interactor 1, dimerization protein	MXI1
91	TGFB1	transforming growth factor, beta 1	TGFB1
92	ERCC6	excision repair cross-complementation group 6	ERCC6
93	STK11	serine/threonine kinase 11	STK11
94	EP300	E1A binding protein p300	EP300
95	APTX	aprataxin	APTX
96	PML	promyelocytic leukemia	PML
97	GSK3B	glycogen synthase kinase 3 beta	GSK3B
98	HTT	huntingtin	HTT
99	PRKCA	protein kinase C, alpha	PRKCA
100	SSTR3	somatostatin receptor 3	SSTR3
101	HELLS	helicase, lymphoid-specific	HELLS
102	APOC3	apolipoprotein C-III	APOC3
103	EEF2	eukaryotic translation elongation factor 2	EEF2
104	ERCC3	excision repair cross-complementation group 3	ERCC3
105	TERF1	telomeric repeat binding factor (NIMA-interacting) 1	TERF1
106	PRKDC	protein kinase, DNA-activated, catalytic polypeptide	PRKDC
107	CAT	catalase	CAT
109	ERCC5	excision repair cross-complementation group 5	ERCC5
110	AR	androgen receptor	AR
111	GTF2H2	general transcription factor IIH, polypeptide 2, 44kDa	GTF2H2
112	XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	XRCC5
113	PCNA	proliferating cell nuclear antigen	PCNA
114	FEN1	flap structure-specific endonuclease 1	FEN1
115	FAS	Fas cell surface death receptor	FAS
116	TERF2	telomeric repeat binding factor 2	TERF2
117	XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	XRCC6
118	POLD1	polymerase (DNA directed), delta 1, catalytic subunit	POLD1
119	BAX	BCL2-associated X protein	BAX
120	RB1	retinoblastoma 1	RB1
121	EMD	emerin	EMD
122	GRB2	growth factor receptor-bound protein 2	GRB2
123	FOXO3	forkhead box O3	FOXO3
124	FOXO1	forkhead box O1	FOXO1
125	HSF1	heat shock transcription factor 1	HSF1
126	XPA	xeroderma pigmentosum, complementation group A	XPA
127	MSRA	methionine sulfoxide reductase A	MSRA
128	RECQL4	RecQ helicase-like 4	RECQL4
129	SOD2	superoxide dismutase 2, mitochondrial	SOD2
130	SOD1	superoxide dismutase 1, soluble	SOD1
131	FOXM1	forkhead box M1	FOXM1
132	COQ7	coenzyme Q7 homolog, ubiquinone (yeast)	COQ7
133	CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	CACNA1A
134	LRP2	low density lipoprotein receptor-related protein 2	LRP2
135	AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	AIFM1
136	UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	UCHL1
137	APP	amyloid beta (A4) precursor protein	APP
138	APOE	apolipoprotein E	APOE
139	A2M	alpha-2-macroglobulin	A2M
140	SNCG	synuclein, gamma (breast cancer-specific protein 1)	SNCG
141	PRDX1	peroxiredoxin 1	PRDX1
142	PON1	paraoxonase 1	PON1
143	RELA	v-rel avian reticuloendotheliosis viral oncogene homolog A	RELA
144	IL6	interleukin 6	IL6
145	RGN	regucalcin	RGN
146	ATP5O	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit	ATP5O
147	RAD52	RAD52 homolog, DNA repair protein	RAD52
148	TOP3B	topoisomerase (DNA) III beta	TOP3B
149	ERCC1	excision repair cross-complementation group 1	ERCC1
150	SIRT1	sirtuin 1	SIRT1
151	HDAC1	histone deacetylase 1	HDAC1
152	HSPA9	heat shock 70kDa protein 9 (mortalin)	HSPA9
153	GPX1	glutathione peroxidase 1	GPX1
154	GSR	glutathione reductase	GSR
155	GSS	glutathione synthetase	GSS
156	GSTA4	glutathione S-transferase alpha 4	GSTA4
157	GSTP1	glutathione S-transferase pi 1	GSTP1
158	MT-CO1	mitochondrially encoded cytochrome c oxidase I	MT-CO1
159	HSPD1	heat shock 60kDa protein 1 (chaperonin)	HSPD1
160	HSPA1A	heat shock 70kDa protein 1A	HSPA1A
161	HSPA1B	heat shock 70kDa protein 1B	HSPA1B
162	PCMT1	protein-L-isoaspartate (D-aspartate) O-methyltransferase	PCMT1
163	MAPK8	mitogen-activated protein kinase 8	MAPK8
164	YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta	YWHAZ
165	PTK2B	protein tyrosine kinase 2 beta	PTK2B
166	PTK2	protein tyrosine kinase 2	PTK2
167	IL7	interleukin 7	IL7
168	MAPK14	mitogen-activated protein kinase 14	MAPK14
169	FGFR1	fibroblast growth factor receptor 1	FGFR1
170	SP1	Sp1 transcription factor	SP1
171	FLT1	fms-related tyrosine kinase 1	FLT1
172	JUN	jun proto-oncogene	JUN
173	MED1	mediator complex subunit 1	MED1
174	MAPK9	mitogen-activated protein kinase 9	MAPK9
175	MAPK3	mitogen-activated protein kinase 3	MAPK3
176	HMGB1	high mobility group box 1	HMGB1
177	CCNA2	cyclin A2	CCNA2
178	HMGB2	high mobility group box 2	HMGB2
179	MAP3K5	mitogen-activated protein kinase kinase kinase 5	MAP3K5
180	TAF1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	TAF1
181	LMNB1	lamin B1	LMNB1
182	SDHC	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa	SDHC
183	FOXO4	forkhead box O4	FOXO4
184	HESX1	HESX homeobox 1	HESX1
185	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	PIK3R1
186	BSCL2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	BSCL2
187	AGPAT2	1-acylglycerol-3-phosphate O-acyltransferase 2	AGPAT2
188	BMI1	BMI1 proto-oncogene, polycomb ring finger	BMI1
189	EEF1A1	eukaryotic translation elongation factor 1 alpha 1	EEF1A1
190	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	TFAP2A
191	BDNF	brain-derived neurotrophic factor	BDNF
192	CREB1	cAMP responsive element binding protein 1	CREB1
193	ATF2	activating transcription factor 2	ATF2
194	TBP	TATA box binding protein	TBP
195	APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1	APEX1
196	HBP1	HMG-box transcription factor 1	HBP1
197	BUB1B	BUB1 mitotic checkpoint serine/threonine kinase B	BUB1B
198	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	PTGS2
199	HSPA8	heat shock 70kDa protein 8	HSPA8
200	SIN3A	SIN3 transcription regulator family member A	SIN3A
201	CDK1	cyclin-dependent kinase 1	CDK1
202	TFDP1	transcription factor Dp-1	TFDP1
203	DDIT3	DNA-damage-inducible transcript 3	DDIT3
204	POLA1	polymerase (DNA directed), alpha 1, catalytic subunit	POLA1
205	MAPT	microtubule-associated protein tau	MAPT
206	CTGF	connective tissue growth factor	CTGF
207	HDAC2	histone deacetylase 2	HDAC2
208	MAX	MYC associated factor X	MAX
209	MXD1	MAX dimerization protein 1	MXD1
210	MDM2	MDM2 proto-oncogene, E3 ubiquitin protein ligase	MDM2
211	SUMO1	small ubiquitin-like modifier 1	SUMO1
212	H2AFX	H2A histone family, member X	H2AFX
213	HOXB7	homeobox B7	HOXB7
214	HOXC4	homeobox C4	HOXC4
215	JAK2	Janus kinase 2	JAK2
216	ESR1	estrogen receptor 1	ESR1
217	LEP	leptin	LEP
218	LEPR	leptin receptor	LEPR
219	NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	NFKBIA
220	CLU	clusterin	CLU
221	MTOR	mechanistic target of rapamycin (serine/threonine kinase)	MTOR
222	GHRHR	growth hormone releasing hormone receptor	GHRHR
223	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	CTNNB1
224	PSEN1	presenilin 1	PSEN1
225	DLL3	delta-like 3 (Drosophila)	DLL3
226	CDKN2A	cyclin-dependent kinase inhibitor 2A	CDKN2A
227	PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	PPP1CA
228	DBN1	drebrin 1	DBN1
229	NOG	noggin	NOG
230	ELN	elastin	ELN
231	ATR	ATR serine/threonine kinase	ATR
232	UCP3	uncoupling protein 3 (mitochondrial, proton carrier)	UCP3
233	ZMPSTE24	zinc metallopeptidase STE24	ZMPSTE24
234	TP63	tumor protein p63	TP63
235	UCP2	uncoupling protein 2 (mitochondrial, proton carrier)	UCP2
236	POLB	polymerase (DNA directed), beta	POLB
237	GCLC	glutamate-cysteine ligase, catalytic subunit	GCLC
238	GCLM	glutamate-cysteine ligase, modifier subunit	GCLM
239	SIRT6	sirtuin 6	SIRT6
240	BUB3	BUB3 mitotic checkpoint protein	BUB3
241	RAE1	ribonucleic acid export 1	RAE1
242	PMCH	pro-melanin-concentrating hormone	PMCH
243	MLH1	mutL homolog 1	MLH1
244	CSNK1E	casein kinase 1, epsilon	CSNK1E
245	STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	STUB1
246	PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	PPM1D
247	CHEK2	checkpoint kinase 2	CHEK2
248	PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	PCK1
249	ARHGAP1	Rho GTPase activating protein 1	ARHGAP1
250	CDC42	cell division cycle 42	CDC42
251	ARNTL	aryl hydrocarbon receptor nuclear translocator-like	ARNTL
252	CLOCK	clock circadian regulator	CLOCK
253	HIC1	hypermethylated in cancer 1	HIC1
254	PAPPA	pregnancy-associated plasma protein A, pappalysin 1	PAPPA
255	ADCY5	adenylate cyclase 5	ADCY5
256	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	PPARGC1A
257	GPX4	glutathione peroxidase 4	GPX4
258	UCP1	uncoupling protein 1 (mitochondrial, proton carrier)	UCP1
259	FGF23	fibroblast growth factor 23	FGF23
260	EFEMP1	EGF containing fibulin-like extracellular matrix protein 1	EFEMP1
261	ERCC4	excision repair cross-complementation group 4	ERCC4
262	CETP	cholesteryl ester transfer protein, plasma	CETP
263	PPARG	peroxisome proliferator-activated receptor gamma	PPARG
264	AGTR1	angiotensin II receptor, type 1	AGTR1
265	CISD2	CDGSH iron sulfur domain 2	CISD2
266	EEF1E1	eukaryotic translation elongation factor 1 epsilon 1	EEF1E1
267	EPS8	epidermal growth factor receptor pathway substrate 8	EPS8
268	KCNA3	potassium channel, voltage gated shaker related subfamily A, member 3	KCNA3
269	SIRT7	sirtuin 7	SIRT7
270	SLC13A1	solute carrier family 13 (sodium/sulfate symporter), member 1	SLC13A1
271	SOCS2	suppressor of cytokine signaling 2	SOCS2
273	TPP2	tripeptidyl peptidase II	TPP2
274	TP53BP1	tumor protein p53 binding protein 1	TP53BP1
275	SIRT3	sirtuin 3	SIRT3
276	NCOR2	nuclear receptor corepressor 2	NCOR2
277	SUN1	Sad1 and UNC84 domain containing 1	SUN1
278	BAK1	BCL2-antagonist/killer 1	BAK1
279	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	IGFBP2
280	PYCR1	pyrroline-5-carboxylate reductase 1	PYCR1
281	TP73	tumor protein p73	TP73
282	CNR1	cannabinoid receptor 1 (brain)	CNR1
283	NFE2L2	nuclear factor, erythroid 2-like 2	NFE2L2
284	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	CDKN1A
285	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	PDGFRA
286	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	PIK3CA
287	C1QA	complement component 1, q subcomponent, A chain	C1QA
288	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	CDKN2B
289	EIF5A2	eukaryotic translation initiation factor 5A2	EIF5A2
290	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	MIF
291	DGAT1	diacylglycerol O-acyltransferase 1	DGAT1
292	MT1E	metallothionein 1E	MT1E
293	FGF21	fibroblast growth factor 21	FGF21
294	HTRA2	HtrA serine peptidase 2	HTRA2
295	GSK3A	glycogen synthase kinase 3 alpha	GSK3A
296	NUDT1	nudix (nucleoside diphosphate linked moiety X)-type motif 1	NUDT1
297	IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	IKBKB
298	SQSTM1	sequestosome 1	SQSTM1
299	CDK7	cyclin-dependent kinase 7	CDK7
300	GRN	granulin	GRN
301	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	SERPINE1
302	SPRTN	SprT-like N-terminal domain	SPRTN
303	RICTOR	RPTOR independent companion of MTOR, complex 2	RICTOR
304	CTF1	cardiotrophin 1	CTF1
305	TRAP1	TNF receptor-associated protein 1	TRAP1
306	TRPV1	transient receptor potential cation channel subfamily V member 1	TRPV1
307	NFE2L1	nuclear factor, erythroid 2-like 1	NFE2L1
308	IFNB1	Interferon beta	IFNB1
309	GDF11	growth differentiation factor 11	GDF11