GenAge entry for AKT1 (Homo sapiens)

Gene name (HAGRID: 35)

HGNC symbol
AKT1 
Aliases
RAC; PKB; PRKBA; AKT 
Common name
v-akt murine thymoma viral oncogene homolog 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

AKT1 is a protein kinase that is also considered an oncogene. It appears to mediate insulin's (INS) actions and be involved in the signal transduction of growth factors such as IGF1. AKT1 also impacts on cell survival and development, and it activates NFKB1 [333]. AKT1 null mice are smaller but viable and more susceptible to genotoxic stress and apoptosis [327]. Haploinsufficient mice have a lower body weight and a slightly longer lifespan (8% for males and 15% for females) [3259].

In roundworms, two AKT1 homologues play a role in insulin-like signalling and influence dauer formation [948]. Knockdown of akt-1 in roundworms extended lifespan [3259]. AKT1 also appears to play a role in cellular senescence [1660]. Some evidence suggests AKT1 may play a role in ageing through its impact on energy metabolism [823], but its role, if any, on human ageing remains elusive.

Cytogenetic information

Cytogenetic band
14q32.32
Location
104,769,350 bp to 104,793,601 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000060; protein import into nucleus, translocation
GO:0001649; osteoblast differentiation
GO:0001893; maternal placenta development
GO:0001934; positive regulation of protein phosphorylation
GO:0001938; positive regulation of endothelial cell proliferation
GO:0005978; glycogen biosynthetic process
GO:0005979; regulation of glycogen biosynthetic process
GO:0006006; glucose metabolic process
GO:0006412; translation
GO:0006417; regulation of translation
GO:0006464; cellular protein modification process
And 109 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005819; spindle
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005911; cell-cell junction
GO:0015630; microtubule cytoskeleton
GO:0031982; vesicle
GO:0036064; ciliary basal body
And 3 more GO terms
Function: GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0004712; protein serine/threonine/tyrosine kinase activity
GO:0005080; protein kinase C binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0005547; phosphatidylinositol-3,4,5-trisphosphate binding
GO:0016301; kinase activity
GO:0019899; enzyme binding
GO:0030235; nitric-oxide synthase regulator activity
GO:0032794; GTPase activating protein binding
And 5 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TERT, HDAC3, IRS1, AKT1, PIK3CB, EGFR, BRCA1, PTEN, CREBBP, VCP, HSP90AA1, PDPK1, EP300, GSK3B, PRKDC, AR, FOXO3, FOXO1, UCHL1, APP, SIRT1, HSPA9, MAPK8, YWHAZ, MAPK14, MAPK9, MAP3K5, FOXO4, CREB1, HSPA8, MAPT, MXD1, MDM2, ESR1, MTOR, CTNNB1, PPP1CA, SIRT6, STUB1, NCOR2, NFE2L2, CDKN1A, PIK3CA, GSK3A, IKBKB, RICTOR
STRING interaction network
Protein-Protein network diagram for AKT1

Retrieve sequences for AKT1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
akt-2
Caenorhabditis elegans
akt-1
Danio rerio
AKT1
Drosophila melanogaster
Akt1
Mus musculus
Akt1
Rattus norvegicus
Akt1
Saccharomyces cerevisiae
SCH9
Saccharomyces cerevisiae
YPK1
Saccharomyces cerevisiae
YPK2

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as akt-1
  • A homolog of this gene for Saccharomyces cerevisiae is present as SCH9
  • A homolog of this gene for Drosophila melanogaster is present as Akt1
  • A homolog of this gene for Saccharomyces cerevisiae is present as YPK1
  • A homolog of this gene for Mus musculus is present as Akt1
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as SCH9
LongevityMap
  • This gene is present as AKT1
CellAge
  • This gene is present as AKT1

Selected references

External links

EPD
ORF Accession
NM_005163
CDS Accession
NP_005154
OMIM
164730
HPRD
01261
Ensembl
AKT1
UniProt/Swiss-Prot
AKT1_HUMAN
GeneCards
AKT1
Entrez Gene
207
UniGene
525622
GenAtlas
AKT1
Internet
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