GenAge entry for ERCC3 (Homo sapiens)

Gene name (HAGRID: 104)

HGNC symbol
ERCC3 
Aliases
XPB; BTF2; RAD25; TFIIH; GTF2H 
Common name
excision repair cross-complementation group 3 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

ERCC3 is a helicase and a component of the TFIIH basal transcription factor [544]. Mutations in ERCC3 cause Xeroderma Pigmentosum group B [547]. Due to its role in DNA repair in association with the other ERCC proteins, some of which directly related to ageing in mammals, it is possible ERCC3 plays a role in human ageing.

Cytogenetic information

Cytogenetic band
2q21
Location
127,257,290 bp to 127,294,176 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000717; nucleotide-excision repair, DNA duplex unwinding
GO:0001666; response to hypoxia
GO:0006265; DNA topological change
GO:0006281; DNA repair
GO:0006283; transcription-coupled nucleotide-excision repair
GO:0006289; nucleotide-excision repair
GO:0006293; nucleotide-excision repair, preincision complex stabilization
GO:0006294; nucleotide-excision repair, preincision complex assembly
GO:0006295; nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296; nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006361; transcription initiation from RNA polymerase I promoter
And 21 more GO terms
Cellular component: GO:0000439; core TFIIH complex
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005669; transcription factor TFIID complex
GO:0005675; holo TFIIH complex
Function: GO:0003677; DNA binding
GO:0003684; damaged DNA binding
GO:0004003; ATP-dependent DNA helicase activity
GO:0004386; helicase activity
GO:0004672; protein kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0005525; GTP binding
GO:0008022; protein C-terminus binding
GO:0008094; DNA-dependent ATPase activity
GO:0008134; transcription factor binding
And 7 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, ERCC2, E2F1, MYC, ERCC6, ERCC5, AR, GTF2H2, RAD52, CDC42, CDK7
STRING interaction network
Protein-Protein network diagram for ERCC3

Retrieve sequences for ERCC3

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
xpb-1
Danio rerio
ercc3
Drosophila melanogaster
hay
Mus musculus
Ercc3
Rattus norvegicus
Ercc3
Saccharomyces cerevisiae
SSL2
Schizosaccharomyces pombe
ercc3

In other databases

LongevityMap
  • This gene is present as ERCC3

Selected references

External links

EPD
HS_ERCC3
ORF Accession
NM_000122
CDS Accession
NP_000113
OMIM
133510
HPRD
00593
Ensembl
ERCC3
UniProt/Swiss-Prot
ERCC3_HUMAN
GeneCards
ERCC3
Entrez Gene
2071
UniGene
469872
GenAtlas
ERCC3
Internet
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