GenAge entry for A2M (Homo sapiens)

Gene name (HAGRID: 139)

HGNC symbol
A2M 
Aliases
FWP007; S863-7; CPAMD5 
Common name
alpha-2-macroglobulin 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

A2M inhibits proteinases. Knockout mice are more resistant to endotoxins [702], though they have not been shown to live longer. In humans, A2M has been associated with neurodegenerative diseases [703], but a direct association with human ageing has not been established.

Cytogenetic information

Cytogenetic band
12p13.31
Location
9,067,708 bp to 9,115,962 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001869; negative regulation of complement activation, lectin pathway
GO:0002576; platelet degranulation
GO:0007597; blood coagulation, intrinsic pathway
GO:0010951; negative regulation of endopeptidase activity
GO:0022617; extracellular matrix disassembly
GO:0043547; positive regulation of GTPase activity
GO:0048863; stem cell differentiation
GO:0051056; regulation of small GTPase mediated signal transduction
Cellular component: GO:0005576; extracellular region
GO:0005829; cytosol
GO:0031093; platelet alpha granule lumen
GO:0070062; extracellular exosome
GO:0072562; blood microparticle
Function: GO:0002020; protease binding
GO:0004867; serine-type endopeptidase inhibitor activity
GO:0005096; GTPase activator activity
GO:0005102; receptor binding
GO:0005515; protein binding
GO:0019838; growth factor binding
GO:0019899; enzyme binding
GO:0019959; interleukin-8 binding
GO:0019966; interleukin-1 binding
GO:0043120; tumor necrosis factor binding
GO:0048306; calcium-dependent protein binding
And 1 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
NGF, GRB2, APP, APOE, A2M, H2AFX, LEP, TP63, CDC42, CDKN1A, CDK7
STRING interaction network
Protein-Protein network diagram for A2M

Retrieve sequences for A2M

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
100101650
Danio rerio
793100
Danio rerio
CABZ01075618.1
Danio rerio
562067
Danio rerio
566238
Danio rerio
100003785
Danio rerio
100006782
Danio rerio
zgc:171426
Danio rerio
si:ch211-212c13.8
Danio rerio
100136837
Danio rerio
a2ml
Danio rerio
100006947
Danio rerio
793035
Drosophila melanogaster
Mcr
Drosophila melanogaster
Tep2
Drosophila melanogaster
Tep3
Drosophila melanogaster
Tep1
Drosophila melanogaster
Tep4
Drosophila melanogaster
Tep5
Mus musculus
A2m
Rattus norvegicus
LOC100911545
Rattus norvegicus
A2m

Selected references

External links

EPD
ORF Accession
NM_000014
CDS Accession
NP_000005
OMIM
103950
HPRD
00072
Ensembl
A2M
UniProt/Swiss-Prot
A2MG_HUMAN
GeneCards
A2M
Entrez Gene
2
UniGene
212838
GenAtlas
A2M
Internet
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