GenAge entry for CAT (Homo sapiens)
Gene name (HAGRID: 107)
- HGNC symbol
- CAT
- Aliases
- Common name
- catalase
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
- Description
Catalase is an antioxidant that protects cells from hydrogen peroxide. Some experiments in invertebrates suggest a role for CAT in ageing. Overexpression of CAT and SOD1 in short-lived strains of fruit flies extends lifespan and appears to delay ageing [39], but the same effects are not witnessed in long-lived strains [40]. CAT overexpression targeted to mitochondria extends longevity in mice, but this appears to be related to a lower incidence of cardiac pathology rather than delayed ageing [1335]. These mutants are also more resistant to age-related skeletal muscle dysfunction and exhibit improved voluntary exercise, increased muscle force, decreased intracellular Ca(2+) leak and increased sarcoplasmic reticulum Ca(2+) load [3638]. Cardiac-specific overexpression prolongs lifespan in mice [1941]. Although it has been argued that CAT plays a role in ageing, there is no direct evidence linking CAT to human ageing.
Cytogenetic information
- Cytogenetic band
- 11p13
- Location
- 34,438,925 bp to 34,472,060 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000302; response to reactive oxygen species
GO:0001649; osteoblast differentiation
GO:0001657; ureteric bud development
GO:0001666; response to hypoxia
GO:0006195; purine nucleotide catabolic process
GO:0006641; triglyceride metabolic process
GO:0007568; aging
GO:0008203; cholesterol metabolic process
GO:0009060; aerobic respiration
GO:0009642; response to light intensity
GO:0009650; UV protection
And 28 more GO terms Cellular component: GO:0005615; extracellular space
GO:0005739; mitochondrion
GO:0005758; mitochondrial intermembrane space
GO:0005764; lysosome
GO:0005777; peroxisome
GO:0005778; peroxisomal membrane
GO:0005782; peroxisomal matrix
GO:0005783; endoplasmic reticulum
GO:0005794; Golgi apparatus
GO:0005829; cytosol
GO:0005886; plasma membrane
And 5 more GO terms Function: GO:0004046; aminoacylase activity
GO:0004096; catalase activity
GO:0005102; receptor binding
GO:0016209; antioxidant activity
GO:0016684; oxidoreductase activity, acting on peroxide as acceptor
GO:0019899; enzyme binding
GO:0020037; heme binding
GO:0042803; protein homodimerization activity
GO:0046872; metal ion binding
GO:0050661; NADP binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- PEX5, ABL1, CAT, SOD2, SOD1, APP, PRDX1, ESR1
- STRING interaction network
Retrieve sequences for CAT
Homologs in model organisms
- Caenorhabditis elegans
- ctl-2
- Caenorhabditis elegans
- ctl-3
- Caenorhabditis elegans
- ctl-1
- Danio rerio
- cat
- Drosophila melanogaster
- Cat
- Drosophila melanogaster
- CG9314
- Mus musculus
- Cat
- Rattus norvegicus
- Cat
- Saccharomyces cerevisiae
- CTA1
- Schizosaccharomyces pombe
- cta1
In other databases
- GenAge model organism genes
- LongevityMap
- This gene is present as CAT
Selected references
External links
- EPD
- ORF Accession
- NM_001752
- CDS Accession
- NP_001743
- OMIM
- 115500
- HPRD
- 00282
- Ensembl
- CAT
- UniProt/Swiss-Prot
- CATA_HUMAN
- GeneCards
- CAT
- Entrez Gene
- 847
- GenAtlas
- CAT
- Internet
- Search Google