GenAge entry for ABL1 (Homo sapiens)

Gene name (HAGRID: 78)

HGNC symbol
ABL1 
Aliases
JTK7; c-ABL; p150; ABL 
Common name
ABL proto-oncogene 1, non-receptor tyrosine kinase 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

An important player in cellular proliferation and development, ABL1 also acts as an oncogene [471]. Some results indicate ABL1 might also be involved in DNA repair [474]. Disruption of ABL1 in mice results in severe defects and animals die shortly after birth [472]. Although its exact functions remain elusive, ABL1 has been argued to play a role in ageing due to its interaction with ageing-related genes, such as ATM, and its functions [1292].

Cytogenetic information

Cytogenetic band
9q34.1
Location
130,713,881 bp to 130,887,675 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001922; B-1 B cell homeostasis
GO:0001934; positive regulation of protein phosphorylation
GO:0002322; B cell proliferation involved in immune response
GO:0002333; transitional one stage B cell differentiation
GO:0006298; mismatch repair
GO:0006355; regulation of transcription, DNA-templated
GO:0006464; cellular protein modification process
GO:0006914; autophagy
GO:0006974; cellular response to DNA damage stimulus
GO:0006975; DNA damage induced protein phosphorylation
GO:0006979; response to oxidative stress
And 69 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0015629; actin cytoskeleton
GO:0031234; extrinsic component of cytoplasmic side of plasma membrane
GO:0031252; cell leading edge
GO:0031965; nuclear membrane
GO:0048471; perinuclear region of cytoplasm
And 1 more GO terms
Function: GO:0000287; magnesium ion binding
GO:0003677; DNA binding
GO:0003785; actin monomer binding
GO:0004515; nicotinate-nucleotide adenylyltransferase activity
GO:0004672; protein kinase activity
GO:0004713; protein tyrosine kinase activity
GO:0004715; non-membrane spanning protein tyrosine kinase activity
GO:0005080; protein kinase C binding
GO:0005102; receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
And 8 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, TP53, ATM, EGFR, ERBB2, FOS, PARP1, BRCA1, HSP90AA1, ABL1, RAD51, TERF1, PRKDC, CAT, PCNA, XRCC6, RB1, GRB2, PRDX1, GPX1, HSPD1, YWHAZ, JUN, PIK3R1, CREB1, HSPA8, CDK1, MAPT, MDM2, NFKBIA, MTOR, CTNNB1, ATR, STUB1, TP73
STRING interaction network
Protein-Protein network diagram for ABL1

Retrieve sequences for ABL1

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
abl-1
Danio rerio
abl1
Drosophila melanogaster
Abl
Mus musculus
Abl1
Rattus norvegicus
Abl1
Rattus norvegicus
Abl1
Rattus norvegicus
Abl1

Selected references

External links

EPD
HS_ABL1_3
ORF Accession
NM_007313
CDS Accession
NP_009297
OMIM
189980
HPRD
01809
Ensembl
ABL1
UniProt/Swiss-Prot
ABL1_HUMAN
GeneCards
ABL1
Entrez Gene
25
UniGene
431048
GenAtlas
ABL1
Internet
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