GenAge entry for ABL1 (Homo sapiens)
Gene name (HAGRID: 78)
- HGNC symbol
- ABL1
- Aliases
- JTK7; c-ABL; p150; ABL
- Common name
- ABL proto-oncogene 1, non-receptor tyrosine kinase
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
An important player in cellular proliferation and development, ABL1 also acts as an oncogene [471]. Some results indicate ABL1 might also be involved in DNA repair [474]. Disruption of ABL1 in mice results in severe defects and animals die shortly after birth [472]. Although its exact functions remain elusive, ABL1 has been argued to play a role in ageing due to its interaction with ageing-related genes, such as ATM, and its functions [1292].
Cytogenetic information
- Cytogenetic band
- 9q34.1
- Location
- 130,713,881 bp to 130,887,675 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0001922; B-1 B cell homeostasis
GO:0001934; positive regulation of protein phosphorylation
GO:0002322; B cell proliferation involved in immune response
GO:0002333; transitional one stage B cell differentiation
GO:0006298; mismatch repair
GO:0006355; regulation of transcription, DNA-templated
GO:0006464; cellular protein modification process
GO:0006914; autophagy
GO:0006974; cellular response to DNA damage stimulus
GO:0006975; DNA damage induced protein phosphorylation
GO:0006979; response to oxidative stress
And 69 more GO terms Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0015629; actin cytoskeleton
GO:0031234; extrinsic component of cytoplasmic side of plasma membrane
GO:0031252; cell leading edge
GO:0031965; nuclear membrane
GO:0048471; perinuclear region of cytoplasm
And 1 more GO terms Function: GO:0000287; magnesium ion binding
GO:0003677; DNA binding
GO:0003785; actin monomer binding
GO:0004515; nicotinate-nucleotide adenylyltransferase activity
GO:0004672; protein kinase activity
GO:0004713; protein tyrosine kinase activity
GO:0004715; non-membrane spanning protein tyrosine kinase activity
GO:0005080; protein kinase C binding
GO:0005102; receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
And 8 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- SHC1, TP53, ATM, EGFR, ERBB2, FOS, PARP1, BRCA1, HSP90AA1, ABL1, RAD51, TERF1, PRKDC, CAT, PCNA, XRCC6, RB1, GRB2, PRDX1, GPX1, HSPD1, YWHAZ, JUN, PIK3R1, CREB1, HSPA8, CDK1, MAPT, MDM2, NFKBIA, MTOR, CTNNB1, ATR, STUB1, TP73
- STRING interaction network
Retrieve sequences for ABL1
Homologs in model organisms
- Caenorhabditis elegans
- abl-1
- Danio rerio
- abl1
- Drosophila melanogaster
- Abl
- Mus musculus
- Abl1
- Rattus norvegicus
- Abl1
- Rattus norvegicus
- Abl1
- Rattus norvegicus
- Abl1