GenAge entry for TOP2A (Homo sapiens)
Gene name (HAGRID: 80)
- HGNC symbol
- TOP2A
- Aliases
- TOP2
- Common name
- topoisomerase (DNA) II alpha
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
Topoisomerases regulate the topological states of DNA [483]. Though no direct interaction has been reported, TOP2A has been indirectly linked to WRN [61] and ATM [482]. TOP2A has also been suggested as an important player in neuron proliferation [483]. Because TOP2A has been associated with several DNA metabolism proteins thought to play a role in ageing, it is possible that TOP2A itself is involved in human ageing, though further studies are necessary to confirm this hypothesis.
Cytogenetic information
- Cytogenetic band
- 17q21-q22
- Location
- 40,388,521 bp to 40,417,950 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000712; resolution of meiotic recombination intermediates
GO:0000819; sister chromatid segregation
GO:0002244; hematopoietic progenitor cell differentiation
GO:0006265; DNA topological change
GO:0006266; DNA ligation
GO:0006268; DNA unwinding involved in DNA replication
GO:0006312; mitotic recombination
GO:0006974; cellular response to DNA damage stimulus
GO:0007059; chromosome segregation
GO:0016925; protein sumoylation
GO:0030263; apoptotic chromosome condensation
And 9 more GO terms Cellular component: GO:0000228; nuclear chromosome
GO:0000793; condensed chromosome
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005814; centriole
GO:0009295; nucleoid
GO:0009330; DNA topoisomerase complex (ATP-hydrolyzing)
GO:0019035; viral integration complex
GO:0043234; protein complex
Function: GO:0000287; magnesium ion binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003918; DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080; protein kinase C binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0008094; DNA-dependent ATPase activity
GO:0008144; drug binding
GO:0008301; DNA binding, bending
And 7 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, LMNA, MYC, BRCA1, PIN1, RPA1, BLM, TOP2B, TOP1, UBE2I, GSK3B, PRKCA, XRCC5, TERF2, RB1, HDAC1, JUN, BMI1, HDAC2, ESR1, CTNNB1
- STRING interaction network
Retrieve sequences for TOP2A
Homologs in model organisms
- Caenorhabditis elegans
- cin-4
- Caenorhabditis elegans
- top-2
- Danio rerio
- top2a
- Drosophila melanogaster
- Top2
- Mus musculus
- Top2a
- Rattus norvegicus
- Top2a
- Saccharomyces cerevisiae
- TOP2
In other databases
- CellAge gene expression
- This gene is present as TOP2A
Selected references
External links
- EPD
- ORF Accession
- NM_001067
- CDS Accession
- NP_001058
- OMIM
- 126430
- HPRD
- 00536
- Ensembl
- TOP2A
- UniProt/Swiss-Prot
- TOP2A_HUMAN
- GeneCards
- TOP2A
- Entrez Gene
- 7153
- GenAtlas
- TOP2A
- Internet
- Search Google