GenAge entry for TGFB1 (Homo sapiens)
Gene name (HAGRID: 91)
- HGNC symbol
- TGFB1
- Aliases
- CED; TGFbeta; TGFB; DPD1
- Common name
- transforming growth factor, beta 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
TGFB1 is an important growth factor in development and differentiation. Some evidence suggests TGFB1 is involved in the response to oxidative stress [137]. In roundworms, it has been argued that a TGFB signalling pathway acts downstream of other signals to repress body size and lifespan [1703]. Mutations in TGFB1 have been linked to several pathologies in humans [500], and a polymorphism in this gene has been associated with human longevity [1254]. Nonetheless, it is unclear if/how TGFB1 influences human ageing.
Cytogenetic information
- Cytogenetic band
- 19q13.1
- Location
- 41,330,531 bp to 41,353,933 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000060; protein import into nucleus, translocation
GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000165; MAPK cascade
GO:0001570; vasculogenesis
GO:0001657; ureteric bud development
GO:0001666; response to hypoxia
GO:0001837; epithelial to mesenchymal transition
GO:0001843; neural tube closure
GO:0001933; negative regulation of protein phosphorylation
GO:0001934; positive regulation of protein phosphorylation
GO:0002028; regulation of sodium ion transport
And 170 more GO terms Cellular component: GO:0005576; extracellular region
GO:0005578; proteinaceous extracellular matrix
GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005796; Golgi lumen
GO:0005886; plasma membrane
GO:0005902; microvillus
GO:0009986; cell surface
GO:0030424; axon
GO:0031012; extracellular matrix
And 4 more GO terms Function: GO:0001948; glycoprotein binding
GO:0003823; antigen binding
GO:0005114; type II transforming growth factor beta receptor binding
GO:0005125; cytokine activity
GO:0005160; transforming growth factor beta receptor binding
GO:0005515; protein binding
GO:0008083; growth factor activity
GO:0019899; enzyme binding
GO:0034713; type I transforming growth factor beta receptor binding
GO:0034714; type III transforming growth factor beta receptor binding
GO:0042803; protein homodimerization activity
And 4 more GO terms
Protein interactions and network
Retrieve sequences for TGFB1
Homologs in model organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as daw
- LongevityMap
- This gene is present as TGFB1
Selected references
External links
- EPD
- ORF Accession
- NM_000660
- CDS Accession
- NP_000651
- OMIM
- 190180
- HPRD
- 01821
- Ensembl
- TGFB1
- UniProt/Swiss-Prot
- TGFB1_HUMAN
- GeneCards
- TGFB1
- Entrez Gene
- 7040
- GenAtlas
- TGFB1
- Internet
- Search Google