GenAge entry for UCP1 (Homo sapiens)

Gene name (HAGRID: 258)

HGNC symbol
UCP1 
Aliases
SLC25A7; UCP 
Common name
uncoupling protein 1 (mitochondrial, proton carrier) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

Mitochondrial uncoupling proteins create proton leaks across the inner mitochondrial membrane to uncouple oxidative phosphorylation from ATP synthesis resulting in energy being dissipated as heat. Mice with skeletal muscle-specific UCP1 expression had increased median survival, decreased adiposity, increased temperature and metabolic rate. The same genetic manipulation in APOE null mice decreased diet-induced atherosclerosis and in agouti yellow mice, a model of obesity, diabetes and hypertension were reversed [1850].

Cytogenetic information

Cytogenetic band
4q28-q31
Location
140,559,896 bp to 140,568,805 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0002024; diet induced thermogenesis
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0009266; response to temperature stimulus
GO:0015992; proton transport
GO:0031667; response to nutrient levels
GO:0032870; cellular response to hormone stimulus
GO:0034614; cellular response to reactive oxygen species
GO:0050873; brown fat cell differentiation
GO:0071398; cellular response to fatty acid
GO:1903426; regulation of reactive oxygen species biosynthetic process
GO:1990542; mitochondrial transmembrane transport
And 2 more GO terms
Cellular component: GO:0005739; mitochondrion
GO:0005743; mitochondrial inner membrane
GO:0016021; integral component of membrane
Function: GO:0017077; oxidative phosphorylation uncoupler activity
GO:0022857; transmembrane transporter activity
GO:0032555; purine ribonucleotide binding
GO:0036041; long-chain fatty acid binding
GO:1901612; cardiolipin binding
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for UCP1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
ucp1
Mus musculus
Ucp1
Rattus norvegicus
Ucp1
Rattus norvegicus
LOC100909612
Saccharomyces cerevisiae
DIC1

In other databases

LongevityMap
  • This gene is present as UCP1

Selected references

External links

EPD
ORF Accession
NM_021833
CDS Accession
NP_068605
OMIM
113730
HPRD
00221
Ensembl
UCP1
UniProt/Swiss-Prot
UCP1_HUMAN
GeneCards
UCP1
Entrez Gene
7350
UniGene
249211
GenAtlas
UCP1
Internet
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