GenAge entry for CREB1 (Homo sapiens)

Gene name (HAGRID: 192)

HGNC symbol
CREB1 
Aliases
 
Common name
cAMP responsive element binding protein 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

CREB1 is an important transcription factor involved in a variety of processes. CREB1-null mice die shortly after birth [1729]. Results from mice suggest that CREB1 may contribute to type 2 diabetes [841] and neurodegeneration [843]. CREB1 may also regulate some ageing-related genes such as ATM [1013]. Because it is involved in so many different functions, a role for CREB1 in human ageing is plausible though so far unverified.

Cytogenetic information

Cytogenetic band
2q34
Location
207,529,892 bp to 207,605,560 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001666; response to hypoxia
GO:0006366; transcription from RNA polymerase II promoter
GO:0006468; protein phosphorylation
GO:0007165; signal transduction
GO:0007179; transforming growth factor beta receptor signaling pathway
GO:0007411; axon guidance
GO:0007568; aging
GO:0007595; lactation
GO:0007613; memory
GO:0007623; circadian rhythm
GO:0008361; regulation of cell size
And 38 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005719; nuclear euchromatin
GO:0005759; mitochondrial matrix
GO:0030424; axon
GO:1990589; ATF4-CREB1 transcription factor complex
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980; RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001102; RNA polymerase II activating transcription factor binding
GO:0001190; transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003705; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003712; transcription cofactor activity
GO:0005515; protein binding
GO:0019899; enzyme binding
GO:0030544; Hsp70 protein binding
And 5 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, ATM, AKT1, NCOR1, JUND, BRCA1, CREBBP, NR3C1, ABL1, UBE2I, CEBPB, EP300, GSK3B, HTT, SIRT1, HDAC1, MAPK14, JUN, CREB1, ATF2, HDAC2, CTNNB1, PPP1CA, ATR, GSK3A
STRING interaction network
Protein-Protein network diagram for CREB1

Retrieve sequences for CREB1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
crh-1
Danio rerio
creb1b
Danio rerio
creb1a
Drosophila melanogaster
CrebB
Mus musculus
Creb1
Rattus norvegicus
Creb1
Rattus norvegicus
Creb1

Selected references

External links

EPD
ORF Accession
NM_134442
CDS Accession
NP_604391
OMIM
123810
HPRD
00442
Ensembl
CREB1
UniProt/Swiss-Prot
CREB1_HUMAN
GeneCards
CREB1
Entrez Gene
1385
UniGene
584750
GenAtlas
CREB1
Internet
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