GenAge entry for EIF5A2 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 289)

HGNC symbol
EIF5A2 
Aliases
 
Common name
eukaryotic translation initiation factor 5A2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

A highly conserved gene involved in in translation elongation, EIF5A2 has been associated with cancer [3403]. Its overexpression in mice results in accumulation of chromosomal instability and features resembling accelerated ageing, including a short lifespan, kyphosis, osteoporosis, delay of wound healing and ossification [3246]. Although further studies are needed, EIF5A2 might then play a role in human ageing.

Cytogenetic information

Cytogenetic band
3q26.2
Location
170,888,415 bp to 170,908,637 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006452; translational frameshifting
GO:0007283; spermatogenesis
GO:0008284; positive regulation of cell proliferation
GO:0008612; peptidyl-lysine modification to peptidyl-hypusine
GO:0010509; polyamine homeostasis
GO:0015031; protein transport
GO:0045901; positive regulation of translational elongation
GO:0045905; positive regulation of translational termination
GO:0051028; mRNA transport
Cellular component: GO:0005643; nuclear pore
GO:0005789; endoplasmic reticulum membrane
GO:0005829; cytosol
GO:0043231; intracellular membrane-bounded organelle
Function: GO:0003746; translation elongation factor activity
GO:0005515; protein binding
GO:0043022; ribosome binding
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for EIF5A2

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
eif5a
Drosophila melanogaster
eIF-5A
Mus musculus
Eif5a2
Rattus norvegicus
Eif5a2
Saccharomyces cerevisiae
HYP2
Schizosaccharomyces pombe
tif51b

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Eif5a2

Selected references

External links

EPD
ORF Accession
NM_020390
CDS Accession
NP_065123
OMIM
605782
HPRD
10426
Ensembl
EIF5A2
UniProt/Swiss-Prot
IF5A2_HUMAN
GeneCards
EIF5A2
Entrez Gene
56648
UniGene
164144
GenAtlas
EIF5A2
Internet
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