GenAge entry for SSTR3 (Homo sapiens)

Gene name (HAGRID: 100)

HGNC symbol
SSTR3 
Aliases
 
Common name
somatostatin receptor 3 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

The somatostatin (SST) receptor SSTR3 may play a role in the involution of the human thymus and other age-related pathologies [385]. It have been associated with melanoma [1683]. SSTR3 has not been directly related to ageing, but it could be part of signalling cascades related to ageing.

Cytogenetic information

Cytogenetic band
22q13.1
Location
37,204,237 bp to 37,212,376 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0007187; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007267; cell-cell signaling
GO:0007268; chemical synaptic transmission
GO:0007283; spermatogenesis
GO:0008285; negative regulation of cell proliferation
GO:0008628; hormone-mediated apoptotic signaling pathway
GO:0021549; cerebellum development
GO:0030900; forebrain development
GO:0038170; somatostatin signaling pathway
GO:0042594; response to starvation
GO:0071385; cellular response to glucocorticoid stimulus
And 2 more GO terms
Cellular component: GO:0005737; cytoplasm
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0043005; neuron projection
GO:0060170; ciliary membrane
GO:0097730; non-motile cilium
Function: GO:0004994; somatostatin receptor activity
GO:0005102; receptor binding
GO:0005515; protein binding
GO:0042923; neuropeptide binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SST
STRING interaction network
Protein-Protein network diagram for SSTR3

Retrieve sequences for SSTR3

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
npr-24
Danio rerio
SSTR3 (1 of many)
Danio rerio
sstr3
Drosophila melanogaster
AstC-R1
Drosophila melanogaster
AstC-R2
Mus musculus
Sstr3
Rattus norvegicus
Sstr3

In other databases

LongevityMap
  • This gene is present as SSTR3

Selected references

External links

EPD
ORF Accession
NM_001051
CDS Accession
NP_001042
OMIM
182453
HPRD
01675
Ensembl
SSTR3
UniProt/Swiss-Prot
SSR3_HUMAN
GeneCards
SSTR3
Entrez Gene
6753
UniGene
225995
GenAtlas
SSTR3
Internet
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