GenAge entry for GPX1 (Homo sapiens)

Gene name (HAGRID: 153)

HGNC symbol
GPX1 
Aliases
 
Common name
glutathione peroxidase 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

Mostly present in erythrocytes, GPX1 protects from oxidative damage. Changes in GPX1 have been reported in mice during ageing and due to caloric restriction [243], but there is no direct evidence linking GPX1 to ageing. Mice without GPX1 are more susceptibility to oxidative stress, but do not show signs of premature ageing [741], except for cataracts [742]. Overexpression of GPX1 in mice results in insulin (INS) resistance and obesity [1066]. Results from transgenic mice overexpressing GPX1 in the heart suggest GPX1 could be beneficial to prevent cardiac failure [1711]. Its role, if any, in human ageing remains to be determined.

Cytogenetic information

Cytogenetic band
3p21.3
Location
49,357,176 bp to 49,358,358 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000302; response to reactive oxygen species
GO:0001659; temperature homeostasis
GO:0001885; endothelial cell development
GO:0002862; negative regulation of inflammatory response to antigenic stimulus
GO:0006195; purine nucleotide catabolic process
GO:0006641; triglyceride metabolic process
GO:0006749; glutathione metabolic process
GO:0007605; sensory perception of sound
GO:0008631; intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009410; response to xenobiotic stimulus
GO:0009609; response to symbiotic bacterium
And 31 more GO terms
Cellular component: GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005759; mitochondrial matrix
GO:0005829; cytosol
GO:0070062; extracellular exosome
GO:0097413; Lewy body
Function: GO:0004602; glutathione peroxidase activity
GO:0017124; SH3 domain binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TXN, ABL1
STRING interaction network
Protein-Protein network diagram for GPX1

Retrieve sequences for GPX1

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
gpx-4
Caenorhabditis elegans
gpx-5
Caenorhabditis elegans
gpx-3
Mus musculus
Gpx1
Rattus norvegicus
Gpx1
Saccharomyces cerevisiae
HYR1
Saccharomyces cerevisiae
GPX1

In other databases

LongevityMap
  • This gene is present as GPX1

Selected references

External links

EPD
HS_GPX1
ORF Accession
NM_000581
CDS Accession
NP_000572
OMIM
138320
HPRD
11749
Ensembl
GPX1
UniProt/Swiss-Prot
GPX1_HUMAN
GeneCards
GPX1
Entrez Gene
2876
UniGene
76686
GenAtlas
GPX1
Internet
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