GenAge entry for GCLM (Homo sapiens)

Gene name (HAGRID: 238)

HGNC symbol
GCLM 
Aliases
GLCLR 
Common name
glutamate-cysteine ligase, modifier subunit 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

Glutamate-cysteine ligase, composed of GCLC and GCLM, catalyses the first step in glutathione synthesis. Overexpression of GCLM in fruit flies extended mean and maximum lifespan by up to 50% [1551]. In humans, polymorphisms in GCLM have been associated with myocardial infarction [1555].

Cytogenetic information

Cytogenetic band
1p22.1
Location
93,885,200 bp to 93,909,598 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000096; sulfur amino acid metabolic process
GO:0006534; cysteine metabolic process
GO:0006536; glutamate metabolic process
GO:0006750; glutathione biosynthetic process
GO:0006979; response to oxidative stress
GO:0007568; aging
GO:0007584; response to nutrient
GO:0008637; apoptotic mitochondrial changes
GO:0014823; response to activity
GO:0035229; positive regulation of glutamate-cysteine ligase activity
GO:0035729; cellular response to hepatocyte growth factor stimulus
And 13 more GO terms
Cellular component: GO:0005829; cytosol
GO:0017109; glutamate-cysteine ligase complex
Function: GO:0004357; glutamate-cysteine ligase activity
GO:0030234; enzyme regulator activity
GO:0035226; glutamate-cysteine ligase catalytic subunit binding
GO:0046982; protein heterodimerization activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
EGFR, GCLC
STRING interaction network
Protein-Protein network diagram for GCLM

Retrieve sequences for GCLM

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
E01A2.1
Danio rerio
gclm
Drosophila melanogaster
Gclm
Mus musculus
Gclm
Rattus norvegicus
Gclm
Schizosaccharomyces pombe
SPCC737.06c

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Gclm

Selected references

External links

EPD
ORF Accession
NM_002061
CDS Accession
NP_002052
OMIM
601176
HPRD
03106
Ensembl
GCLM
UniProt/Swiss-Prot
GSH0_HUMAN
GeneCards
GCLM
Entrez Gene
2730
UniGene
315562
GenAtlas
GCLM
Internet
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