GenAge entry for BMI1 (Homo sapiens)

Gene name (HAGRID: 188)

HGNC symbol
BMI1 
Aliases
RNF51; PCGF4 
Common name
BMI1 proto-oncogene, polycomb ring finger 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

BMI1 is an oncogene involved in transcriptional regulation by remodelling chromatin. It may also be involved in development. Overexpression of BMI1 in mice results in transformation of axial skeleton [813]. BMI1-null mice show reduced self-renewal of neural stem cells [811], and thus a role for BMI1 in stem cell senescence has been proposed [1402]. Bmi-1 is downregulated in the aging brain [3325]. Additionally, brains of 8 month old Bmi-1 heterozygous knockout mice display mild oxidative stress through significant increases in hydroxy radical and nitrotyrosine compared with wild-type littermates. The hippocampus of these mice has also a high apoptotic percentage and lipofuscin depositions in pyramidal neurons. Behaviorally, the mice show mild spatial memory impairment, suggesting an early onset of age-related brain changes [3582]. It has also been suggested that Bmi-1 is important for the maintenance of redox balance resulting in a protective role against renal tubulointerstitial injury [3583]. Whether BMI1 impacts on human ageing remains to be determined.

Cytogenetic information

Cytogenetic band
10p11.23
Location
22,321,210 bp to 22,331,485 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006351; transcription, DNA-templated
GO:0007379; segment specification
GO:0010468; regulation of gene expression
GO:0016569; covalent chromatin modification
GO:0016925; protein sumoylation
GO:0030097; hemopoiesis
GO:0045814; negative regulation of gene expression, epigenetic
GO:0048146; positive regulation of fibroblast proliferation
GO:0051443; positive regulation of ubiquitin-protein transferase activity
Cellular component: GO:0000151; ubiquitin ligase complex
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0031519; PcG protein complex
GO:0035102; PRC1 complex
Function: GO:0005515; protein binding
GO:0008270; zinc ion binding
GO:0071535; RING-like zinc finger domain binding
GO:1990841; promoter-specific chromatin binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, ATM, NBN, PARP1, PTEN, CREBBP, TOP2A, UBE2I, EP300, PRKDC, AR, XRCC5, TERF2, AIFM1, HSPA1A, MAPK14, BMI1, H2AFX, DBN1, SOCS2, PYCR1
STRING interaction network
Protein-Protein network diagram for BMI1

Retrieve sequences for BMI1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
bmi1b
Danio rerio
bmi1a
Drosophila melanogaster
Su(z)2
Drosophila melanogaster
Psc
Mus musculus
Bmi1
Rattus norvegicus
Bmi1

In other databases

CellAge
  • This gene is present as BMI1

Selected references

External links

EPD
ORF Accession
NM_005180
CDS Accession
NP_005171
OMIM
164831
HPRD
01277
Ensembl
BMI1
UniProt/Swiss-Prot
BMI1_HUMAN
GeneCards
BMI1
Entrez Gene
648
UniGene
496613
GenAtlas
BMI1
Internet
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