GenAge entry for TOP1 (Homo sapiens)

Gene name (HAGRID: 83)

HGNC symbol
TOP1 
Aliases
 
Common name
topoisomerase (DNA) I 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

Topoisomerases regulate the topological states of DNA. Though no direct interaction has been reported, TOP1 has been indirectly linked to WRN [487]. TOP1 may also be important in the regulation of various brain functions and its activity is age-dependent [1625]. Because TOP1 has been associated with several DNA metabolism proteins thought to play a role in ageing, it is possible that TOP1 is itself involved in human ageing, though further studies are necessary to confirm this hypothesis.

Cytogenetic information

Cytogenetic band
20q12-q13.
Location
41,028,822 bp to 41,124,486 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006260; DNA replication
GO:0006265; DNA topological change
GO:0006338; chromatin remodeling
GO:0007059; chromosome segregation
GO:0007623; circadian rhythm
GO:0012501; programmed cell death
GO:0016032; viral process
GO:0016310; phosphorylation
GO:0016925; protein sumoylation
GO:0032922; circadian regulation of gene expression
GO:0040016; embryonic cleavage
And 2 more GO terms
Cellular component: GO:0000228; nuclear chromosome
GO:0000932; P-body
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0031298; replication fork protection complex
GO:0043204; perikaryon
Function: GO:0001046; core promoter sequence-specific DNA binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003917; DNA topoisomerase type I activity
GO:0005515; protein binding
GO:0044822; poly(A) RNA binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, ATM, ERCC8, IL7R, MYC, PARP1, VCP, TOP2A, TOP2B, UBE2I, XRCC5, PCNA, APP, MDM2, ESR1, CDKN2A, BUB3, SIRT7
STRING interaction network
Protein-Protein network diagram for TOP1

Retrieve sequences for TOP1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
top-1
Danio rerio
top1mt
Drosophila melanogaster
Top1
Mus musculus
Top1
Rattus norvegicus
Top1
Rattus norvegicus
Top1
Saccharomyces cerevisiae
TOP1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as top-1
  • A homolog of this gene for Saccharomyces cerevisiae is present as TOP1
CellAge
  • This gene is present as TOP1

Selected references

External links

EPD
ORF Accession
NM_003286
CDS Accession
NP_003277
OMIM
126420
HPRD
00535
Ensembl
TOP1
UniProt/Swiss-Prot
TOP1_HUMAN
GeneCards
TOP1
Entrez Gene
7150
UniGene
472737
GenAtlas
TOP1
Internet
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