GenAge entry for VEGFA (Homo sapiens)
Gene name (HAGRID: 77)
- HGNC symbol
- VEGFA
- Aliases
- VEGF-A; VPF; VEGF
- Common name
- vascular endothelial growth factor A
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
VEGFA is a growth factor that been widely implicated in age-related changes [1274], tumorigenesis, and neurogenesis [469]. Mutations in the human VEGFA gene have been associated with type 2 diabetes [1674] and atherosclerosis [1675]. Inactivation of VEGFA in mice results in embryonic lethality [470]. It is unclear whether VEGFA is directly involved in ageing, yet it remains a possible player.
Cytogenetic information
- Cytogenetic band
- 6p12
- Location
- 43,770,209 bp to 43,786,486 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001525; angiogenesis
GO:0001541; ovarian follicle development
GO:0001569; branching involved in blood vessel morphogenesis
GO:0001570; vasculogenesis
GO:0001666; response to hypoxia
GO:0001701; in utero embryonic development
GO:0001822; kidney development
GO:0001934; positive regulation of protein phosphorylation
GO:0001938; positive regulation of endothelial cell proliferation
GO:0002042; cell migration involved in sprouting angiogenesis
And 80 more GO terms Cellular component: GO:0005576; extracellular region
GO:0005578; proteinaceous extracellular matrix
GO:0005615; extracellular space
GO:0005737; cytoplasm
GO:0009986; cell surface
GO:0016020; membrane
GO:0030141; secretory granule
GO:0031093; platelet alpha granule lumen
Function: GO:0001968; fibronectin binding
GO:0005125; cytokine activity
GO:0005161; platelet-derived growth factor receptor binding
GO:0005172; vascular endothelial growth factor receptor binding
GO:0005515; protein binding
GO:0008083; growth factor activity
GO:0008201; heparin binding
GO:0042056; chemoattractant activity
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0043183; vascular endothelial growth factor receptor 1 binding
And 5 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- HSP90AA1, VEGFA, FLT1, CTGF
- STRING interaction network
Retrieve sequences for VEGFA
Homologs in model organisms
In other databases
Selected references
External links
- EPD
- ORF Accession
- NM_003376
- CDS Accession
- NP_003367
- OMIM
- 192240
- HPRD
- 01889
- Ensembl
- VEGFA
- UniProt/Swiss-Prot
- VEGFA_HUMAN
- GeneCards
- VEGFA
- Entrez Gene
- 7422
- GenAtlas
- VEGFA
- Internet
- Search Google