GenAge entry for LEPR (Homo sapiens)

Gene name (HAGRID: 218)

HGNC symbol
LEPR 
Aliases
OBR; CD295 
Common name
leptin receptor 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

LEPR is the receptor for leptin (LEP) and is involved in LEP's signal transduction [1221]. The obese spontaneously hypertensive Koletsky rat has been associated with mutations in LEPR [217]. Deletion of LEPR in neurons of mice results in obesity [1742]. Polymorphisms in the human LEPR gene have been associated with obesity, body mass index, and fat mass [1745]. Like LEP, LEPR plays a role in fat metabolism and so could be involved in some aspects of age-related deterioration.

Cytogenetic information

Cytogenetic band
1p31
Location
65,420,652 bp to 65,637,493 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001525; angiogenesis
GO:0006112; energy reserve metabolic process
GO:0006909; phagocytosis
GO:0007166; cell surface receptor signaling pathway
GO:0007275; multicellular organism development
GO:0008203; cholesterol metabolic process
GO:0010507; negative regulation of autophagy
GO:0019953; sexual reproduction
GO:0030217; T cell differentiation
GO:0033210; leptin-mediated signaling pathway
GO:0042593; glucose homeostasis
And 9 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005886; plasma membrane
GO:0016021; integral component of membrane
GO:0016323; basolateral plasma membrane
GO:0043235; receptor complex
Function: GO:0004888; transmembrane signaling receptor activity
GO:0005515; protein binding
GO:0038021; leptin receptor activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
PIN1
STRING interaction network
Protein-Protein network diagram for LEPR

Retrieve sequences for LEPR

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
lepr
Mus musculus
Lepr
Rattus norvegicus
Lepr

In other databases

LongevityMap
  • This gene is present as LEPR

Selected references

External links

EPD
ORF Accession
NM_002303
CDS Accession
NP_002294
OMIM
601007
HPRD
03001
Ensembl
LEPR
UniProt/Swiss-Prot
LEPR_HUMAN
GeneCards
LEPR
Entrez Gene
3953
UniGene
705413
GenAtlas
LEPR
Internet
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