GenAge entry for MAX (Homo sapiens)

Gene name (HAGRID: 208)

HGNC symbol
MAX 
Aliases
bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8 
Common name
MYC associated factor X 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

A transcriptional regulator, MAX can act as pro- or anti-apoptotic. Although MAX has not been associated with ageing, it may be a part of its signalling cascade in conjunction with other proteins such as MXI1 [887].

Cytogenetic information

Cytogenetic band
14q23
Location
65,075,124 bp to 65,102,544 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006366; transcription from RNA polymerase II promoter
GO:0006461; protein complex assembly
GO:0009267; cellular response to starvation
GO:0010629; negative regulation of gene expression
GO:0032868; response to insulin
GO:0048678; response to axon injury
GO:0051402; neuron apoptotic process
GO:0060041; retina development in camera-type eye
GO:0071375; cellular response to peptide hormone stimulus
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0016605; PML body
GO:0030425; dendrite
GO:0071339; MLL1 complex
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000983; transcription factor activity, RNA polymerase II core promoter sequence-specific
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003712; transcription cofactor activity
GO:0003713; transcription coactivator activity
GO:0005515; protein binding
GO:0032403; protein complex binding
GO:0042803; protein homodimerization activity
GO:0046982; protein heterodimerization activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
MYC, HIF1A, HSP90AA1, CEBPA, MXI1, EP300, HSPA1A, MAPK14, TAF1, TFAP2A, TBP, SIN3A, TFDP1, MAX, MXD1, PPP1CA
STRING interaction network
Protein-Protein network diagram for MAX

Retrieve sequences for MAX

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
mxl-1
Caenorhabditis elegans
mxl-3
Danio rerio
max
Drosophila melanogaster
Max
Mus musculus
Max
Rattus norvegicus
Max

Selected references

External links

EPD
ORF Accession
NM_002382
CDS Accession
NP_002373
OMIM
154950
HPRD
01113
Ensembl
MAX
UniProt/Swiss-Prot
MAX_HUMAN
GeneCards
MAX
Entrez Gene
4149
UniGene
285354
GenAtlas
MAX
Internet
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