GenAge entry for EEF1A1 (Homo sapiens)

Gene name (HAGRID: 189)

HGNC symbol
EEF1A1 
Aliases
EE1A1; EF1A; EEF1A; LENG7 
Common name
eukaryotic translation elongation factor 1 alpha 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

EEF1A1 is involved in the binding of tRNA to ribosomes during protein synthesis. In fruit flies, overexpression of EEF1A1 increases longevity [814]. Whether EEF1A1 has any role in mammalian ageing has not been determined.

Cytogenetic information

Cytogenetic band
6q14.1
Location
73,515,750 bp to 73,521,032 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0006414; translational elongation
GO:0071364; cellular response to epidermal growth factor stimulus
GO:1904714; regulation of chaperone-mediated autophagy
Cellular component: GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005853; eukaryotic translation elongation factor 1 complex
GO:0016020; membrane
GO:0030864; cortical actin cytoskeleton
GO:0032587; ruffle membrane
GO:0043209; myelin sheath
GO:0070062; extracellular exosome
And 2 more GO terms
Function: GO:0000049; tRNA binding
GO:0003746; translation elongation factor activity
GO:0003924; GTPase activity
GO:0005515; protein binding
GO:0005525; GTP binding
GO:0019901; protein kinase binding
GO:0044822; poly(A) RNA binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, EGFR, RPA1, HSP90AA1, EP300, GSK3B, EEF2, PCNA, FAS, RAD52, HSPA9, HSPA1A, MAPK14, EEF1A1, HSPA8, MDM2, H2AFX, TP63, SIRT6, CDKN1A, HTRA2, TRAP1
STRING interaction network
Protein-Protein network diagram for EEF1A1

Retrieve sequences for EEF1A1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
eef1a1a
Danio rerio
eef1a1b
Drosophila melanogaster
Ef1alpha100E
Mus musculus
Eef1a1
Rattus norvegicus
Eef1a1
Rattus norvegicus
LOC100360413
Rattus norvegicus
LOC100911991
Saccharomyces cerevisiae
TEF1
Saccharomyces cerevisiae
TEF1

Selected references

External links

EPD
ORF Accession
NM_001402
CDS Accession
NP_001393
OMIM
130590
HPRD
00559
Ensembl
EEF1A1
UniProt/Swiss-Prot
EF1A1_HUMAN
GeneCards
EEF1A1
Entrez Gene
1915
UniGene
520703
GenAtlas
EEF1A1
Internet
Search Google