GenAge entry for MAPK8 (Homo sapiens)

Gene name (HAGRID: 163)

HGNC symbol
MAPK8 
Aliases
JNK; JNK1; SAPK1; PRKM8 
Common name
mitogen-activated protein kinase 8 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

MAPK8, also known as JNK1, encodes many transcripts and is an important player in stress response. In invertebrates, there is evidence linking JNK signalling to ageing. Fruit flies with mutations that augment JNK signalling live longer [212]. Overexpression of JNK in roundworms also increases lifespan [60]. Changes in JNK1 with age have been reported in rat hepatocytes [768]. MAPK8-null mice showed defective T cell differentiation [761]. Mice without MAPK8 and MAPK9 die at embryonic stages [1715]. In mouse models of obesity, absence of MAPK8 decreased adiposity and improved insulin (INS) sensitivity [765]. Although MAPK8 could play a role in ageing-related diseases, further research is needed to determine how MAPK8 is related to human ageing.

Cytogenetic information

Cytogenetic band
10q11.22
Location
48,401,612 bp to 48,439,359 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006468; protein phosphorylation
GO:0006950; response to stress
GO:0007254; JNK cascade
GO:0007258; JUN phosphorylation
GO:0009411; response to UV
GO:0010628; positive regulation of gene expression
GO:0016241; regulation of macroautophagy
GO:0018105; peptidyl-serine phosphorylation
GO:0018107; peptidyl-threonine phosphorylation
GO:0031063; regulation of histone deacetylation
GO:0031281; positive regulation of cyclase activity
And 14 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
Function: GO:0004674; protein serine/threonine kinase activity
GO:0004705; JUN kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016301; kinase activity
GO:0019899; enzyme binding
GO:0035033; histone deacetylase regulator activity
GO:0042826; histone deacetylase binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, STAT3, IRS1, AKT1, HRAS, MYC, EGFR, JUND, BCL2, PDPK1, CEBPA, EP300, PRKDC, FAS, RB1, HSF1, APP, SNCG, SIRT1, HDAC1, GSTP1, MAPK8, YWHAZ, SP1, JUN, MAPK9, ATF2, HSPA8, MAPT, H2AFX, MTOR, CTNNB1, CDKN2A, CDC42, NFE2L2, CDKN1A
STRING interaction network
Protein-Protein network diagram for MAPK8

Retrieve sequences for MAPK8

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
jnk-1
Danio rerio
mapk8a
Danio rerio
mapk8b
Drosophila melanogaster
bsk
Mus musculus
Mapk8
Rattus norvegicus
Mapk8
Saccharomyces cerevisiae
HOG1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as jnk-1
  • A homolog of this gene for Drosophila melanogaster is present as bsk

Selected references

External links

EPD
ORF Accession
NM_139049
CDS Accession
NP_620637
OMIM
601158
HPRD
03100
Ensembl
MAPK8
UniProt/Swiss-Prot
MK08_HUMAN
GeneCards
MAPK8
Entrez Gene
5599
UniGene
138211
GenAtlas
MAPK8
Internet
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