GenAge entry for GPX4 (Homo sapiens)

Gene name (HAGRID: 257)

HGNC symbol
GPX4 
Aliases
PHGPx; MCSP 
Common name
glutathione peroxidase 4 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

GPX4 is an antioxidant, in particular involved in the detoxification of oxidative damage to membrane lipids. The median lifespan was slightly (about 7%) but significantly increased in heterozygous knockout mice when compared to controls. Heterozygous knockout mice showed a delayed occurrence of fatal tumor lymphoma as well as increased sensitivity apoptosis induced by oxidative stress [1848].

Cytogenetic information

Cytogenetic band
19p13.3
Location
1,103,926 bp to 1,106,789 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006644; phospholipid metabolic process
GO:0006979; response to oxidative stress
GO:0007275; multicellular organism development
GO:0019372; lipoxygenase pathway
GO:0055114; oxidation-reduction process
GO:0098869; cellular oxidant detoxification
Cellular component: GO:0005634; nucleus
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0070062; extracellular exosome
Function: GO:0004602; glutathione peroxidase activity
GO:0047066; phospholipid-hydroperoxide glutathione peroxidase activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
PIN1, SOD2, SOD1
STRING interaction network
Protein-Protein network diagram for GPX4

Retrieve sequences for GPX4

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
gpx4b
Danio rerio
gpx4a
Mus musculus
Gpx4
Rattus norvegicus
Gpx4
Saccharomyces cerevisiae
HYR1
Saccharomyces cerevisiae
GPX1
Schizosaccharomyces pombe
gpx1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Gpx4
LongevityMap
  • This gene is present as GPX4

Selected references

External links

EPD
HS_GPX4
ORF Accession
NM_002085
CDS Accession
NP_002076
OMIM
138322
HPRD
11819
Ensembl
GPX4
UniProt/Swiss-Prot
GPX4_HUMAN
GeneCards
GPX4
Entrez Gene
2879
UniGene
433951
GenAtlas
GPX4
Internet
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